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MeSH Review

Pongo pygmaeus

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Disease relevance of Pongo pygmaeus


High impact information on Pongo pygmaeus

  • We sequenced the complementary DNAs that encode the FOXP2 protein in the chimpanzee, gorilla, orang-utan, rhesus macaque and mouse, and compared them with the human cDNA [6].
  • Similarities of the skull are commonly used to support hypotheses of ancestor-descendant relationships between fossil and living ape genera, especially between the late Miocene apes Sivapithecus and Dryopithecus from Eurasia and the living orang-utan (Pongo) from Borneo and Sumatra [7].
  • These data support the view that the theta 1-gene has been functional in the baboon, orang-utan, and by implication, in man [8].
  • This structural difference in the promoter between the orang-utan theta 1- and alpha 1-genes has led Proudfoot to speculate that the theta 1-gene may be inactive [8].
  • The putative polypeptide is 141 amino acids long, identical to that of the alpha- or zeta-globin, but its predicted amino-acid sequence is nearly as different from the orang-utan alpha-globin (55 differences) as the human zeta-globin is from the human alpha-globin (59 differences), suggesting an ancient history for the theta 1-globin gene [9].

Biological context of Pongo pygmaeus


Anatomical context of Pongo pygmaeus


Associations of Pongo pygmaeus with chemical compounds


Gene context of Pongo pygmaeus


Analytical, diagnostic and therapeutic context of Pongo pygmaeus


  1. The phylogeography of orangutan foamy viruses supports the theory of ancient repopulation of Sumatra. Verschoor, E.J., Langenhuijzen, S., Bontjer, I., Fagrouch, Z., Niphuis, H., Warren, K.S., Eulenberger, K., Heeney, J.L. J. Virol. (2004) [Pubmed]
  2. Interactions of decay-accelerating factor (DAF) with haemagglutinating human enteroviruses: utilizing variation in primate DAF to map virus binding sites. Williams, D.T., Chaudhry, Y., Goodfellow, I.G., Lea, S., Evans, D.J. J. Gen. Virol. (2004) [Pubmed]
  3. Sylvatic transmission of arboviruses among Bornean orangutans. Wolfe, N.D., Kilbourn, A.M., Karesh, W.B., Rahman, H.A., Bosi, E.J., Cropp, B.C., Andau, M., Spielman, A., Gubler, D.J. Am. J. Trop. Med. Hyg. (2001) [Pubmed]
  4. Diverticulitis with rupture and fatal peritonitis in a Sumatran orangutan (Pongo pygmaeus). Murray, S., Zdziarski, J.M., Bush, M., Citino, S.B., Schulman, F.Y., Montali, R. Comp. Med. (2000) [Pubmed]
  5. Clinical effects and plasma concentrations of fentanyl after transmucosal administration in three species of great ape. Hunter, R.P., Isaza, R., Carpenter, J.W., Koch, D.E. J. Zoo Wildl. Med. (2004) [Pubmed]
  6. Molecular evolution of FOXP2, a gene involved in speech and language. Enard, W., Przeworski, M., Fisher, S.E., Lai, C.S., Wiebe, V., Kitano, T., Monaco, A.P., Pääbo, S. Nature (2002) [Pubmed]
  7. Earliest known Old World monkey skull. Benefit, B.R., McCrossin, M.L. Nature (1997) [Pubmed]
  8. Evidence that the recently discovered theta 1-globin gene is functional in higher primates. Shaw, J.P., Marks, J., Shen, C.K. Nature (1987) [Pubmed]
  9. Sequence organization and genomic complexity of primate theta 1 globin gene, a novel alpha-globin-like gene. Marks, J., Shaw, J.P., Shen, C.K. Nature (1986) [Pubmed]
  10. Genomic differentiation among natural populations of orang-utan (Pongo pygmaeus). Zhi, L., Karesh, W.B., Janczewski, D.N., Frazier-Taylor, H., Sajuthi, D., Gombek, F., Andau, M., Martenson, J.S., O'Brien, S.J. Curr. Biol. (1996) [Pubmed]
  11. Identification and measurement of urinary estrone, estradiol-17 beta, estriol, pregnanediol and androsterone during the menstrual cycle of the orangutan. Collins, D.C., Graham, C.E., Preedy, J.R. Endocrinology (1975) [Pubmed]
  12. mtDNA sequence diversity of orangutans from the islands of Borneo and Sumatra. Muir, C.C., Galdikas, B.M., Beckenbach, A.T. J. Mol. Evol. (2000) [Pubmed]
  13. Further characterization of a herpesvirus-positive orang-utan cell line and comparative aspects of in vitro transformation with lymphotropic old world primate herpesviruses. Rabin, H., Neubauer, R.H., Hopkins, R.F., Nonoyama, M. Int. J. Cancer (1978) [Pubmed]
  14. Differences of superoxide production in blood leukocytes stimulated with thymol between human and non-human primates. Suzuki, Y., Nakamura, S., Sugiyama, K., Furuta, H. Life Sci. (1987) [Pubmed]
  15. Identification and quantitation of steroids in sulfate fractions from plasma of pregnant chimpanzee, orangutan, and rhesus monkey. Axelson, M., Graham, C.E., Sjövall, J. Endocrinology (1984) [Pubmed]
  16. Reproductive hormone profiles in captive male orangutans: implications for understanding developmental arrest. Maggioncalda, A.N., Sapolsky, R.M., Czekala, N.M. Am. J. Phys. Anthropol. (1999) [Pubmed]
  17. C4 genes of the chimpanzee, gorilla, and orang-utan: evidence for extensive homogenization. Kawaguchi, H., Zaleska-Rutczynska, Z., Figueroa, F., O'hUigin, C., Klein, J. Immunogenetics (1992) [Pubmed]
  18. Complex events in the evolution of the haptoglobin gene cluster in primates. McEvoy, S.M., Maeda, N. J. Biol. Chem. (1988) [Pubmed]
  19. Evidence for an HLA-C-like locus in the orangutan Pongo pygmaeus. Adams, E.J., Thomson, G., Parham, P. Immunogenetics (1999) [Pubmed]
  20. Polymorphism of C4 and CYP21 genes in various primate species. Bontrop, R.E., Broos, L.A., Otting, N., Jonker, M.J. Tissue Antigens (1991) [Pubmed]
  21. Increased SOD1 enzymatic activity and gene modifications in orangutans: evolutionary implications. de Grouchy, J., Nicole, A., Cochet, C., Sinet, P.M., Créau-Goldberg, N. Hum. Genet. (1991) [Pubmed]
  22. Nuclear DNA-binding proteins determined by the Epstein-Barr virus-related simian lymphotropic herpesviruses H. gorilla, H. pan, H. pongo and H. papio. Dillner, J., Rabin, H., Letvin, N., Henle, W., Henle, G., Klein, G. J. Gen. Virol. (1987) [Pubmed]
  23. Radioimmunoassay of estrone conjugates from urine dried on filter paper. Knott, C.D. Am. J. Primatol. (2005) [Pubmed]
  24. Developmental changes in the facial morphology of the Borneo orangutan (Pongo pygmaeus): possible signals in visual communication. Kuze, N., Malim, T.P., Kohshima, S. Am. J. Primatol. (2005) [Pubmed]
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