The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CDase  -  Ceramidase

Drosophila melanogaster

Synonyms: CG1471, Dmel\CG1471, N-CDase, NCDase, Neutral N-acylsphingosine amidohydrolase, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CDase


High impact information on CDase


Biological context of CDase


Anatomical context of CDase

  • Here, we show that expression of ceramidase facilitates the dissolution of incompletely formed and inappropriately located elements of rhabdomeric membranes in ninaE(I17) mutants lacking the G protein receptor Rh1 in R1-R6 photoreceptor cells [1].

Associations of CDase with chemical compounds

  • Suppression of degeneration in arrestin mutant flies expressing ceramidase correlated with a decrease in ceramide levels [4].

Regulatory relationships of CDase

  • Consistent with a cell-nonautonomous function, overexpression of ceramidase in tissues distant from photoreceptors suppresses photoreceptor degeneration in an arrestin mutant and facilitates membrane turnover in a rhodopsin null mutant [5].

Analytical, diagnostic and therapeutic context of CDase


  1. Ceramidase expression facilitates membrane turnover and endocytosis of rhodopsin in photoreceptors. Acharya, U., Mowen, M.B., Nagashima, K., Acharya, J.K. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Molecular cloning and characterization of a secretory neutral ceramidase of Drosophila melanogaster. Yoshimura, Y., Okino, N., Tani, M., Ito, M. J. Biochem. (2002) [Pubmed]
  3. Ceramidase regulates synaptic vesicle exocytosis and trafficking. Rohrbough, J., Rushton, E., Palanker, L., Woodruff, E., Matthies, H.J., Acharya, U., Acharya, J.K., Broadie, K. J. Neurosci. (2004) [Pubmed]
  4. Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Acharya, U., Patel, S., Koundakjian, E., Nagashima, K., Han, X., Acharya, J.K. Science (2003) [Pubmed]
  5. Cell-nonautonomous function of ceramidase in photoreceptor homeostasis. Acharya, J.K., Dasgupta, U., Rawat, S.S., Yuan, C., Sanxaridis, P.D., Yonamine, I., Karim, P., Nagashima, K., Brodsky, M.H., Tsunoda, S., Acharya, U. Neuron (2008) [Pubmed]
WikiGenes - Universities