Disease relevance of INVS

• Only recently, INVS has been identified as the gene that is mutated in nephronophthisis type 2, an autosomal recessive polycystic kidney disease [1].
• Infantile nephronophthisis is associated with cystic kidneys, situs inversus, and INVS mutations [2].
• Thus, the shortest possible constructed INV should be effective in clinical conditions such as Crohn's disease, but the recommended length in short bowel syndrome should be greater than this [3].

High impact information on INVS

• After microtubule depolymerization using colcemid inversin and tubulin staining is no longer characterized by a network pattern but by homogeneous, diffuse distribution [1].
• In conclusion, inversin is closely associated with the microtubule cytoskeleton, and its spatial distribution is dependent on tubulin polymerization [1].
• After removal of colcemid, inversin immunofluorescence reappears together with tubulin in centrioles [1].
• The aim of the present study was to examine what length of intussusception-like nipple valve (INV) should be constructed in order to restore the hydrostatic characteristics of the normal ileocecal valve [3].

Analytical, diagnostic and therapeutic context of INVS

• We used Northern blots, RT-PCR, and sequence analysis to identify alternative INVS transcripts [2].

References