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MeSH Review

Short Bowel Syndrome

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Disease relevance of Short Bowel Syndrome


Psychiatry related information on Short Bowel Syndrome

  • We conclude that serum leptin levels in patients with anorexia nervosa and short bowel syndrome are significantly lower than in healthy individuals and have no statistically significant relation to serum total protein, abumin, and prealbumin [6].

High impact information on Short Bowel Syndrome

  • Improved nutrient absorption after cimetidine in short-bowel syndrome with gastric hypersecretion [7].
  • Since 1995, 5 key clinical studies have been published in peer-reviewed literature reporting the effects of growth hormone alone or in combination with glutamine and diet in patients with short bowel syndrome [8].
  • In this review, the nature of the short bowel syndrome is described, and the antisecretory, transit-modulating, but also intestinotrophic effects of GLP-2 are presented [9].
  • Conclusions: In patients with short-bowel syndrome, postabsorptive plasma citrulline concentration is a marker of functional absorptive bowel length and, past the 2-year adaptive period, a powerful independent indicator allowing distinction of transient from permanent intestinal failure [10].
  • This study compared the effect of a natural conjugated bile acid mixture from ox bile with that of cholylsarcosine, a synthetic conjugated bile acid, on fat absorption and diarrhea in a patient with the short-bowel syndrome [11].

Chemical compound and disease context of Short Bowel Syndrome


Biological context of Short Bowel Syndrome


Anatomical context of Short Bowel Syndrome


Gene context of Short Bowel Syndrome


Analytical, diagnostic and therapeutic context of Short Bowel Syndrome


  1. Splanchnic transplantation. An approach to the infant dependent on parenteral nutrition who develops irreversible liver disease. Williams, J.W., Sankary, H.N., Foster, P.F., Loew, J.M., Goldman, G.M., Lowe, J. JAMA (1989) [Pubmed]
  2. Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation. Theiss, A.L., Fuller, C.R., Simmons, J.G., Liu, B., Sartor, R.B., Lund, P.K. Gastroenterology (2005) [Pubmed]
  3. Streptococcus bovis catheter infection and the short bowel syndrome. Kaye, B.R., Kearns, P.J. Am. J. Med. (1986) [Pubmed]
  4. Short-chain fatty acid-supplemented total parenteral nutrition alters intestinal structure, glucose transporter 2 (GLUT2) mRNA and protein, and proglucagon mRNA abundance in normal rats. Tappenden, K.A., Drozdowski, L.A., Thomson, A.B., McBurney, M.I. Am. J. Clin. Nutr. (1998) [Pubmed]
  5. Fecal microflora in a patient with short-bowel syndrome and identification of dominant lactobacilli. Kaneko, T., Bando, Y., Kurihara, H., Satomi, K., Nonoyama, K., Matsuura, N. J. Clin. Microbiol. (1997) [Pubmed]
  6. Relationship of serum leptin levels and selected nutritional parameters in patients with protein-caloric malnutrition. Haluzík, M., Kábrt, J., Nedvídková, J., Svobodová, J., Kotrlíková, E., Papezová, H. Nutrition (Burbank, Los Angeles County, Calif.) (1999) [Pubmed]
  7. Improved nutrient absorption after cimetidine in short-bowel syndrome with gastric hypersecretion. Cortot, A., Fleming, C.R., Malagelada, J.R. N. Engl. J. Med. (1979) [Pubmed]
  8. Short bowel syndrome: recent clinical outcomes with growth hormone. Scolapio, J.S. Gastroenterology (2006) [Pubmed]
  9. Glucagon-like peptide-2: update of the recent clinical trials. Jeppesen, P.B. Gastroenterology (2006) [Pubmed]
  10. Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Crenn, P., Coudray-Lucas, C., Thuillier, F., Cynober, L., Messing, B. Gastroenterology (2000) [Pubmed]
  11. Conjugated bile acid replacement therapy for short-bowel syndrome. Gruy-Kapral, C., Little, K.H., Fordtran, J.S., Meziere, T.L., Hagey, L.R., Hofmann, A.F. Gastroenterology (1999) [Pubmed]
  12. Intestinal absorption of free oral hyperalimentation in the very short bowel syndrome. Messing, B., Pigot, F., Rongier, M., Morin, M.C., Ndeïndoum, U., Rambaud, J.C. Gastroenterology (1991) [Pubmed]
  13. Octreotide in the treatment of refractory diarrhoea and intestinal fistulae. Farthing, M.J. Gut (1994) [Pubmed]
  14. Inhibition of postprandial pancreatic and biliary secretion by loperamide in patients with short bowel syndrome. Remington, M., Fleming, C.R., Malagelada, J.R. Gut (1982) [Pubmed]
  15. Tolerance and absorption of lactose from milk and yogurt during short-bowel syndrome in humans. Arrigoni, E., Marteau, P., Briet, F., Pochart, P., Rambaud, J.C., Messing, B. Am. J. Clin. Nutr. (1994) [Pubmed]
  16. Efficacy of water-soluble vitamin E in the treatment of vitamin E malabsorption in short-bowel syndrome. Traber, M.G., Schiano, T.D., Steephen, A.C., Kayden, H.J., Shike, M. Am. J. Clin. Nutr. (1994) [Pubmed]
  17. Four year nutritional follow up after living related small bowel transplantation between monozygotic twins. Genton, L., Raguso, C.A., Berney, T., Hans, D.B., Morel, P., Pichard, C. Gut (2003) [Pubmed]
  18. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant glucagon-like peptide 2 analogue, improves intestinal function in short bowel syndrome patients. Jeppesen, P.B., Sanguinetti, E.L., Buchman, A., Howard, L., Scolapio, J.S., Ziegler, T.R., Gregory, J., Tappenden, K.A., Holst, J., Mortensen, P.B. Gut (2005) [Pubmed]
  19. Bone mineral content in patients with short bowel syndrome: the impact of parenteral nutrition. Ament, M.E. J. Pediatr. (1998) [Pubmed]
  20. Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome. Martin, G.R., Wallace, L.E., Hartmann, B., Holst, J.J., Demchyshyn, L., Toney, K., Sigalet, D.L. Am. J. Physiol. Gastrointest. Liver Physiol. (2005) [Pubmed]
  21. Basal energy expenditure and diet- induced modifications to thermogenesis in short bowel syndrome. Justino, S.R., Dias, M.C., Maculevicius, J., Colugnati, F.A., Sing, T.C., Halpern, A., Gama-Rodrigues, J., Waitzberg, D.L. Clinical nutrition (Edinburgh, Scotland) (2005) [Pubmed]
  22. Gastric acid secretion and gastrin production in the short bowel syndrome. Williams, N.S., Evans, P., King, R.F. Gut (1985) [Pubmed]
  23. Effect of IGF-rich colostrum on bowel adaptation in neonatal piglets with short bowel syndrome. Heemskerk, V.H., van Heurn, L.W., Farla, P., Buurman, W.A., Piersma, F., ter Riet, G., Heineman, E. J. Pediatr. Gastroenterol. Nutr. (2002) [Pubmed]
  24. Nine year's survival with short bowel syndrome after occlusion of the superior mesenteric artery in an elderly man: a study of periods of parenteral nutrition. Jacobson, S. JPEN. Journal of parenteral and enteral nutrition. (1982) [Pubmed]
  25. Effects of melatonin administration on intestinal adaptive response after massive bowel resection in rats. Ozturk, H., Oztürk, H., Yagmur, Y., Uzunlar, A.K. Dig. Dis. Sci. (2006) [Pubmed]
  26. Amelioration of anemia after kidney transplantation in severe secondary oxalosis. Bernhardt, W.M., Schefold, J.C., Weichert, W., Rudolph, B., Frei, U., Groneberg, D.A., Schindler, R. Clin. Nephrol. (2006) [Pubmed]
  27. Biological actions and therapeutic potential of the glucagon-like peptides. Drucker, D.J. Gastroenterology (2002) [Pubmed]
  28. Epidermal growth factor and the short bowel syndrome. Thompson, J.S. JPEN. Journal of parenteral and enteral nutrition. (1999) [Pubmed]
  29. Plasma ghrelin levels in patients with short bowel syndrome. Krsek, M., Rosická, M., Haluzík, M., Svobodová, J., Kotrlíková, E., Justová, V., Lacinová, Z., Jarkovská, Z. Endocr. Res. (2002) [Pubmed]
  30. Intestinal and renal calcium-binding protein in rats with experimental short bowel syndrome. Staun, M., Egfjord, M., Fahrenkrug, L. Gastroenterology (1991) [Pubmed]
  31. Management of short bowel syndrome: avoidance of total parenteral nutrition. Jeejeebhoy, K.N. Gastroenterology (2006) [Pubmed]
  32. Parenteral nutrition at home for 5 years via arteriovenous fistulae. Supplemental intravenous feedings for a patient with severe short bowel syndrome. Heizer, W.D., Orringer, E.P. Gastroenterology (1977) [Pubmed]
  33. Energy absorption as a measure of intestinal failure in the short bowel syndrome. Rodrigues, C.A., Lennard-Jones, J.E., Thompson, D.G., Farthing, M.J. Gut (1989) [Pubmed]
  34. Proximal muscle weakness and selenium deficiency associated with long term parenteral nutrition. Brown, M.R., Cohen, H.J., Lyons, J.M., Curtis, T.W., Thunberg, B., Cochran, W.J., Klish, W.J. Am. J. Clin. Nutr. (1986) [Pubmed]
  35. Isotonic high-sodium oral rehydration solution for increasing sodium absorption in patients with short-bowel syndrome. Beaugerie, L., Cosnes, J., Verwaerde, F., Dupas, H., Lamy, P., Gendre, J.P., Le Quintrec, Y. Am. J. Clin. Nutr. (1991) [Pubmed]
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