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Gene Review

GluRIB  -  Glutamate receptor IB

Drosophila melanogaster

Synonyms: CG42509, CG43743, CG4481, DGluR-IB, Dm_3L:43677, ...
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High impact information on Glu-RIB

  • C. elegans glutamate receptor ion pores, at a position homologous to a highly conserved site critical for ion permeation properties in vertebrate glutamate receptor pores, contain amino acids not found in vertebrate glutamate receptors [1].
  • Whole-mount in situ hybridization on embryos revealed DGluR-IB and DNMDAR-II transcripts in the CNS [2].
  • However, the mean open time of extrajunctional glutamate receptor channels was not changed by octopamine [3].
  • By virtue of their multiple protein-binding domains (e.g., three PDZs in PSD-95 and seven PDZs in GRIP), PSD-95 and GRIP can function as multivalent proteins that organize a specific cytoskeletal and signaling complex associated with each class of glutamate receptor [4].
  • No increase of the internal Ca2+ concentration in myotubes was observed when the external solution contained either glutamate at a desensitizing concentration (1 mM) or a glutamate receptor channel blocker, argiotoxin (1 microg/ml) [5].

Biological context of Glu-RIB


Analytical, diagnostic and therapeutic context of Glu-RIB

  • Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation [1].
  • Immunofluorescence analysis of the adult fly brain indicates that the DGluR-IB protein is expressed in neurons implicated in the regulation of the circadian clock [2].
  • The inside-out configuration of the patch-clamp technique was used to study the effects of large organic cations on the single-channel current through the glutamate receptor channel in muscles of Drosophila larvae [7].


  1. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm, N., Werner, M., Madsen, D.M., Seebohm, G., Zheng, Y., Walker, C.S., Maricq, A.V., Hollmann, M. J. Biol. Chem. (2003) [Pubmed]
  2. Novel CNS glutamate receptor subunit genes of Drosophila melanogaster. Völkner, M., Lenz-Böhme, B., Betz, H., Schmitt, B. J. Neurochem. (2000) [Pubmed]
  3. Octopamine inhibits synaptic transmission at the larval neuromuscular junction in Drosophila melanogaster. Nishikawa, K., Kidokoro, Y. Brain Res. (1999) [Pubmed]
  4. Glutamate receptor anchoring proteins and the molecular organization of excitatory synapses. Sheng, M., Pak, D.T. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  5. Distribution of functional glutamate receptors in cultured embryonic Drosophila myotubes revealed using focal release of L-glutamate from caged compound by laser. Saitoe, M., Koshimoto, H., Hirano, M., Suga, T., Kidokoro, Y. J. Neurosci. Methods (1998) [Pubmed]
  6. Activation kinetics of glutamate receptor channels from wild-type Drosophila muscle. Heckmann, M., Parzefall, F., Dudel, J. Pflugers Arch. (1996) [Pubmed]
  7. Permeation of organic cations and ammonium through the glutamate receptor channel in Drosophila larval muscle. Ciani, S., Nishikawa, K., Kidokoro, Y. Jpn. J. Physiol. (1997) [Pubmed]
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