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Gene Review

Eip93F  -  Ecdysone-induced protein 93F

Drosophila melanogaster

Synonyms: CG18389, Dmel\CG18389, E93, Eip93f, anon-WO02059370.58, ...
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High impact information on Eip93F


Biological context of Eip93F

  • Together, these observations indicate that betaFTZ-F1 regulates the timing of hormone-induced cell responses, while E93 functions to specify programmed cell death [3].
  • Mutations in the steroid-regulated genes BR-C and E93 differentially impact larval midgut cell death but do not affect the formation of adult midgut epithelia [4].
  • They demonstrate a remarkable degree of overlap between the control of apoptosis and autophagy as well as a key role for the steroid-inducible gene E93 in directing the autophagic death response [5].

Anatomical context of Eip93F


Associations of Eip93F with chemical compounds

  • The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone [7].

Other interactions of Eip93F

  • Expression of E93 in embryos is sufficient to induce cell death with many characteristics of apoptosis, but requires the H99 genetic interval that contains the rpr, hid and grim proapoptotic genes to induce nuclear changes diagnostic of apoptosis [6].
  • Among other developmental regulators, the Drosophila cell death protein E93 was found to contain a Psq motif and to define a third subgroup of Psq domain proteins [8].


  1. E93 directs steroid-triggered programmed cell death in Drosophila. Lee, C.Y., Wendel, D.P., Reid, P., Lam, G., Thummel, C.S., Baehrecke, E.H. Mol. Cell (2000) [Pubmed]
  2. Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Daish, T.J., Cakouros, D., Kumar, S. Cell Death Differ. (2003) [Pubmed]
  3. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Lee, C.Y., Simon, C.R., Woodard, C.T., Baehrecke, E.H. Dev. Biol. (2002) [Pubmed]
  4. Steroid regulation of midgut cell death during Drosophila development. Lee, C.Y., Cooksey, B.A., Baehrecke, E.H. Dev. Biol. (2002) [Pubmed]
  5. Steroid-triggered death by autophagy. Thummel, C.S. Bioessays (2001) [Pubmed]
  6. Steroid regulation of autophagic programmed cell death during development. Lee, C.Y., Baehrecke, E.H. Development (2001) [Pubmed]
  7. The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone. Baehrecke, E.H., Thummel, C.S. Dev. Biol. (1995) [Pubmed]
  8. The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins. Siegmund, T., Lehmann, M. Dev. Genes Evol. (2002) [Pubmed]
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