The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

MT1X  -  metallothionein 1X

Homo sapiens

Synonyms: MT-1X, MT-1l, MT-IX, MT1, Metallothionein-1X, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of MT1X

 

High impact information on MT1X

 

Biological context of MT1X

 

Anatomical context of MT1X

 

Associations of MT1X with chemical compounds

  • It was shown that acute exposure to either As(3+) or Cd(2+) increased the levels of mRNAs for the MT-1E, MT-1X, and MT-2A genes, whereas extended exposure only increased these mRNAs following exposure to Cd(2+) [9].
 

Other interactions of MT1X

  • On the other hand, the structures of MT1H and MT1X are consistent with these genes being functional and encoding unique type 1 isoforms [8].
  • Treatment with As3+ resulted in a significant increase in the expression of the MT-1X gene and appearance of mRNA for the MT-1A gene [10].
 

Analytical, diagnostic and therapeutic context of MT1X

  • Using competitive RT-PCR, cells resistant to 500 microM zinc showed 7+/-2 fold (SD, n=3) increases in expression of MT-1X and 6+/-3 fold increases in expression of MT-2A compared to control cells in normal media [2].
  • Separation of the isoforms of MT by reversed-phase high-performance liquid chromatography and sequence analysis showed besides MT-1e and MT-1l the isoform-MT-1g, which is not expressed in the healthy kidney, and MT-1k, an isoform which is not yet demonstrated in renal tissues [11].

References

  1. Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer. Garrett, S.H., Sens, M.A., Shukla, D., Flores, L., Somji, S., Todd, J.H., Sens, D.A. Prostate (2000) [Pubmed]
  2. Metallothionein isoform expression by breast cancer cells. Barnes, N.L., Ackland, M.L., Cornish, E.J. Int. J. Biochem. Cell Biol. (2000) [Pubmed]
  3. Differential expression of the MT-1E gene in estrogen-receptor-positive and -negative human breast cancer cell lines. Friedline, J.A., Garrett, S.H., Somji, S., Todd, J.H., Sens, D.A. Am. J. Pathol. (1998) [Pubmed]
  4. Genistein protects prostate cells against hydrogen peroxide-induced DNA damage and induces expression of genes involved in the defence against oxidative stress. Raschke, M., Rowland, I.R., Magee, P.J., Pool-Zobel, B.L. Carcinogenesis (2006) [Pubmed]
  5. Post-transcriptional regulation of metallothionein isoform 1 and 2 expression in the human breast and the MCF-10A cell line. Gurel, V., Sens, D.A., Somji, S., Garrett, S.H., Weiland, T., Sens, M.A. Toxicol. Sci. (2005) [Pubmed]
  6. Metallothionein isogene transcription in red blood cell precursors from human cord blood. Rahman, M.T., De Ley, M. Eur. J. Biochem. (2001) [Pubmed]
  7. Metallothionein isoform 1 and 2 gene expression in the human bladder: evidence for upregulation of MT-1X mRNA in bladder cancer. Somji, S., Sens, M.A., Lamm, D.L., Garrett, S.H., Sens, D.A. Cancer Detect. Prev. (2001) [Pubmed]
  8. Characterisation of six additional human metallothionein genes. Stennard, F.A., Holloway, A.F., Hamilton, J., West, A.K. Biochim. Biophys. Acta (1994) [Pubmed]
  9. Metallothionein isoform 1 and 2 gene expression in a human urothelial cell line (UROtsa) exposed to CdCl2 and NaAsO2. Sens, D., Rossi, M., Park, S., Gurel, V., Nath, J., Garrett, S., Sens, M.A., Somji, S. J. Toxicol. Environ. Health Part A (2003) [Pubmed]
  10. Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells. Garrett, S.H., Belcastro, M., Sens, M.A., Somji, S., Sens, D.A. J. Toxicol. Environ. Health Part A (2001) [Pubmed]
  11. Metallothioneins in human kidneys and associated tumors. Hellemans, G., Soumillion, A., Proost, P., Van Damme, J., Van Poppel, H., Baert, L., De Ley, M. Nephron (1999) [Pubmed]
 
WikiGenes - Universities