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Gene Review

MTNR1A  -  melatonin receptor 1A

Homo sapiens

Synonyms: MEL-1A-R, MT1, Mel-1A-R, Mel1a receptor, Melatonin receptor type 1A
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Disease relevance of MTNR1A


High impact information on MTNR1A


Biological context of MTNR1A


Associations of MTNR1A with chemical compounds

  • Dissociation constants for competition of 11 partial agonists and antagonist for 2-[125I]-iodomelatonin binding were between 15.5 (luzindole, pKi: 7.7) to 362 (4-phenyl-2-chloroacetamidotetraline, pKi: 9.1) fold higher for the Mel1b than for the Mel1a melatonin receptor [10].


  1. Antiproliferative action of melatonin on human prostate cancer LNCaP cells. Moretti, R.M., Marelli, M.M., Maggi, R., Dondi, D., Motta, M., Limonta, P. Oncol. Rep. (2000) [Pubmed]
  2. Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor. Reppert, S.M., Godson, C., Mahle, C.D., Weaver, D.R., Slaugenhaupt, S.A., Gusella, J.F. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding. Gubitz, A.K., Reppert, S.M. Endocrinology (2000) [Pubmed]
  4. Pharmacological characterization of the human melatonin Mel1a receptor following stable transfection into NIH3T3 cells. Nonno, R., Lucini, V., Pannacci, M., Mazzucchelli, C., Angeloni, D., Fraschini, F., Stankov, B.M. Br. J. Pharmacol. (1998) [Pubmed]
  5. Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels. Conway, S., Drew, J.E., Canning, S.J., Barrett, P., Jockers, R., Strosberg, A.D., Guardiola-Lemaitre, B., Delagrange, P., Morgan, P.J. FEBS Lett. (1997) [Pubmed]
  6. Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Slaugenhaupt, S.A., Roca, A.L., Liebert, C.B., Altherr, M.R., Gusella, J.F., Reppert, S.M. Genomics (1995) [Pubmed]
  7. The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. Drew, J.E., Barrett, P., Williams, L.M., Conway, S., Morgan, P.J. J. Neuroendocrinol. (1998) [Pubmed]
  8. Mutagenesis of human Mel1a melatonin receptor expressed in yeast reveals domains important for receptor function. Kokkola, T., Watson, M.A., White, J., Dowell, S., Foord, S.M., Laitinen, J.T. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. Identification and characterisation of 2-[125I]iodomelatonin binding and Mel1a melatonin receptor expression in the human fetal leptomeninges. Drew, J.E., Williams, L.M., Hannah, L.T., Barrett, P., Abramovich, D.R., Morgan, P.J. Brain Res. (1997) [Pubmed]
  10. Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor. Dubocovich, M.L., Masana, M.I., Iacob, S., Sauri, D.M. Naunyn Schmiedebergs Arch. Pharmacol. (1997) [Pubmed]
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