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Gene Review

GPR50  -  G protein-coupled receptor 50

Homo sapiens

Synonyms: H9, Mel1c, Melatonin-related receptor
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Disease relevance of GPR50


Psychiatry related information on GPR50


High impact information on GPR50


Biological context of GPR50


Anatomical context of GPR50


Associations of GPR50 with chemical compounds

  • Thus, the mutation of glycine 20 to threonine, the corresponding H9 residue, severely reduced the receptor's affinity for melatonin [12].
  • Furthermore, expression of the ovine melatonin-related receptor is shown to be coincident with Mel1a and 2-[125I]iodomelatonin binding in the pituitary and serotonin N-acetyl transferase (arylalkylamine N-acetyl transferase, AANAT) expression in the retina [9].
  • Glucosamine also inhibited incorporation of radiolabelled myristic acid into H9 cell proteins in vivo [11].

Other interactions of GPR50


Analytical, diagnostic and therapeutic context of GPR50


  1. Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels. Bhattacharyya, S., Luan, J., Challis, B., Keogh, J., Montague, C., Brennand, J., Morten, J., Lowenbeim, S., Jenkins, S., Farooqi, I.S., Wareham, N.J., O'Rahilly, S. J. Lipid Res. (2006) [Pubmed]
  2. Conserved cysteine and histidine residues in the putative zinc finger motif of the influenza A virus M1 protein are not critical for influenza virus replication. Hui, E.K., Ralston, K., Judd, A.K., Nayak, D.P. J. Gen. Virol. (2003) [Pubmed]
  3. Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor. Thomson, P.A., Wray, N.R., Thomson, A.M., Dunbar, D.R., Grassie, M.A., Condie, A., Walker, M.T., Smith, D.J., Pulford, D.J., Muir, W., Blackwood, D.H., Porteous, D.J. Mol. Psychiatry (2005) [Pubmed]
  4. Lack of association of an insertion/deletion polymorphism in the G protein-coupled receptor 50 with bipolar disorder in a Northern Swedish population. Alaerts, M., Venken, T., Lenaerts, A.S., De Zutter, S., Norrback, K.F., Adolfsson, R., Del-Favero, J. Psychiatr. Genet. (2006) [Pubmed]
  5. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. Levoye, A., Dam, J., Ayoub, M.A., Guillaume, J.L., Couturier, C., Delagrange, P., Jockers, R. EMBO J. (2006) [Pubmed]
  6. Chimeric melatonin mt1 and melatonin-related receptors. Identification of domains and residues participating in ligand binding and receptor activation of the melatonin mt1 receptor. Conway, S., Drew, J.E., Mowat, E.S., Barrett, P., Delagrange, P., Morgan, P.J. J. Biol. Chem. (2000) [Pubmed]
  7. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50). Gubitz, A.K., Reppert, S.M. Genomics (1999) [Pubmed]
  8. Cloning of a melatonin-related receptor from human pituitary. Reppert, S.M., Weaver, D.R., Ebisawa, T., Mahle, C.D., Kolakowski, L.F. FEBS Lett. (1996) [Pubmed]
  9. The ovine melatonin-related receptor: cloning and preliminary distribution and binding studies. Drew, J.E., Barrett, P., Williams, L.M., Conway, S., Morgan, P.J. J. Neuroendocrinol. (1998) [Pubmed]
  10. Photoperiodic regulation of cellular retinoic acid-binding protein 1, GPR50 and nestin in tanycytes of the third ventricle ependymal layer of the Siberian hamster. Barrett, P., Ivanova, E., Graham, E.S., Ross, A.W., Wilson, D., Pl??, H., Mercer, J.G., Ebling, F.J., Schuhler, S., Dupr??, S.M., Loudon, A., Morgan, P.J. J. Endocrinol. (2006) [Pubmed]
  11. Inhibition by glucosamine of myristoylation in human H9 lymphocytes and rat liver cells. Jacobsen, C., Andreassen, H., Saermark, T. FEBS Lett. (1989) [Pubmed]
  12. Chimeric and point-mutated receptors reveal that a single glycine residue in transmembrane domain 6 is critical for high affinity melatonin binding. Gubitz, A.K., Reppert, S.M. Endocrinology (2000) [Pubmed]
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