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Gene Review

Pi3K68D  -  Phosphotidylinositol 3 kinase 68D

Drosophila melanogaster

Synonyms: 11621, BcDNA:LD15217, CG11621, Cpk, Dmel\CG11621, ...
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Disease relevance of Pi3K68D

  • TRB3 expression is remarkably reduced in prostate cancer PC-3 cells after inhibition of PI 3-kinase [1].
  • We also report that PI3K controls the expression and localization of synaptic markers in human neuroblastoma cells, suggesting that PI3K synaptogenic activity is conserved in humans [2].

High impact information on Pi3K68D

  • Thus, Dp110 integrates inputs from its phosphotyrosine-binding adaptor and Ras to achieve maximal PI(3)K signalling in specific biological situations [3].
  • The Drosophila class I PI(3)K, Dp110, is activated by nutrient-responsive insulin signalling and modulates growth, oogenesis and metabolism [3].
  • In contrast, using both laser ablation and a novel wounding assay that allows localized treatment with inhibitory drugs, we show that PI3K is essential for hemocyte chemotaxis toward wounds and that Pvf signals and PDGF/VEGF receptor expression are not required for this rapid chemotactic response [4].
  • These results indicate that the endogenous PI3K_68D may act antagonistically to the EGF receptor-stimulated Ras-mitogen-activated protein kinase pathway and downstream of, or parallel to, the Notch receptor [5].
  • A class II polyproline motif in PI3K_68D can bind the Drk adaptor protein in vitro, primarily via the N-terminal SH3 domain of Drk [5].

Biological context of Pi3K68D


Anatomical context of Pi3K68D

  • We report here the cloning of a novel PI 3-kinase, p170, from cDNA of insulin-sensitive mouse 3T3-L1 adipocytes [8].
  • Thus DOCK180 contained a phosphoinositide-binding domain, as did the other guanine nucleotide exchange factors with a Dbl homology domain, and was translocated to the plasma membrane on the activation of PI-3K [9].
  • We show here that the levels of phosphoinositide 3 kinase (PI3K) regulate synapse number in both Drosophila larval motor neurons and adult brain projection neurons [2].
  • Previous work in our laboratory has indicated that the steroid hormone ecdysone triggers programmed autophagy in the fat body of Drosophila larvae by downregulating the class I phosphoinositide 3-kinase (PI3K) pathway [10].

Associations of Pi3K68D with chemical compounds

  • The PI3K_68D cDNA encodes a protein of 210 kDa, which lacks sequences implicated in linking p110 PI 3-kinases to p85 adaptor proteins, but contains an amino-terminal proline-rich sequence, which could bind to SH3 domains, and a carboxy-terminal C2 domain [6].
  • Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain [7].
  • This finding suggests that Cpk function may be regulated by tyrosine kinases [7].
  • Cpk has an intrinsic PtdIns kinase activity and can phosphorylate PtdIns and PtdIns-4-P, but not PtdIns(4,5)P2, at the D3 position of the inositol ring [7].
  • TRB3 expression is furthermore controlled by nutrient supplies: Both the lack of glucose or amino acids results in a substantial increase in TRB3 protein levels in a PI 3-kinase-dependent manner [1].


  1. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Schwarzer, R., Dames, S., Tondera, D., Klippel, A., Kaufmann, J. Cell. Signal. (2006) [Pubmed]
  2. Age-independent synaptogenesis by phosphoinositide 3 kinase. Mart??n-Pe??a, A., Acebes, A., Rodr??guez, J.R., Sorribes, A., de Polavieja, G.G., Fern??ndez-F??nez, P., Ferr??s, A. J. Neurosci. (2006) [Pubmed]
  3. Input from Ras is required for maximal PI(3)K signalling in Drosophila. Orme, M.H., Alrubaie, S., Bradley, G.L., Walker, C.D., Leevers, S.J. Nat. Cell Biol. (2006) [Pubmed]
  4. Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. Wood, W., Faria, C., Jacinto, A. J. Cell Biol. (2006) [Pubmed]
  5. Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways. MacDougall, L.K., Gagou, M.E., Leevers, S.J., Hafen, E., Waterfield, M.D. Mol. Cell. Biol. (2004) [Pubmed]
  6. A family of phosphoinositide 3-kinases in Drosophila identifies a new mediator of signal transduction. MacDougall, L.K., Domin, J., Waterfield, M.D. Curr. Biol. (1995) [Pubmed]
  7. Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. Molz, L., Chen, Y.W., Hirano, M., Williams, L.T. J. Biol. Chem. (1996) [Pubmed]
  8. Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. Virbasius, J.V., Guilherme, A., Czech, M.P. J. Biol. Chem. (1996) [Pubmed]
  9. Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3. Kobayashi, S., Shirai, T., Kiyokawa, E., Mochizuki, N., Matsuda, M., Fukui, Y. Biochem. J. (2001) [Pubmed]
  10. How a RING finger protein and a steroid hormone control autophagy. Lindmo, K., Stenmark, H. Autophagy. (2006) [Pubmed]
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