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Gene Review

CLEC11A  -  C-type lectin domain family 11, member A

Homo sapiens

Synonyms: C-type lectin domain family 11 member A, C-type lectin superfamily member 3, CLECSF3, LSLCL, Lymphocyte secreted C-type lectin, ...
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Disease relevance of CLEC11A


High impact information on CLEC11A


Chemical compound and disease context of CLEC11A


Biological context of CLEC11A


Anatomical context of CLEC11A

  • CONCLUSION: SCGF is selectively produced by osseous and hematopoietic stromal cells, and can mediate their proliferative activity on primitive hematopoietic progenitor cells [16].
  • METHODS: Recombinant human (rh) SCGF-alpha was purified from a conditioned medium of SCGF-alpha gene-transfected CHO cells [16].
  • A human myeloid cell line, KPB-M15, constitutively produces a novel hematopoietic cytokine, termed stem cell growth factor (SCGF), possessing species-specific proliferative activities [10].
  • The KPB-M15 myeloid cell line constitutionally secreted a considerable quantity of SCGF, while other T- or myeloid-monocytoid cell lines did not secrete SCGF [17].
  • A hybridoma clone (7H1) resulting from the fusion between CEMLAI/NP and human embryonic fibroblasts MRC5 cells produced very large amounts of P47 that was purified using Jacalin lectin (specific for O-glycans) and microsequenced [12].

Associations of CLEC11A with chemical compounds

  • This observation suggests that patients with CGD may also have a defect in lymphocyte function. p47 protein and mRNA levels increase during retinoic acid-induced neutrophil differentiation of HL60 cells [18].
  • It is not known if activation of PKC occurs with pairs of agonists, such as epinephrine and A23187, that do not individually phosphorylate p47, nor is it known what role the concentration of cytoplasmic Ca++ ([Ca++]i) plays in these events [19].
  • Nuclear run-on transcription assays show that the gene for p47 is induced at the transcriptional level in a cycloheximide-insensitive manner [18].
  • These results suggest that p47, but not p67, is a participant with membrane and/or other cytosol components in early arachidonate-dependent reactions [5].
  • Rapid phosphorylation of a human platelet protein of Mr 40,000-47,000 (P47), a substrate for protein kinase C activation, preceded secretion of serotonin when platelets were triggered by the most active heptaacyl MLA ion, m/z 1953 [20].

Other interactions of CLEC11A

  • On transfer to fresh liquid culture with VEGF and SCGF, nonadherent cells again produce an adherent and a nonadherent population [21].
  • The recombinant protein was added to liquid cultures of CD34+ human marrow cells stimulated with IL-3 alone or with both IL-3 and either insulin-like growth factor II (IGF-II) or stem cell growth factor (SCF) [22].
  • The largest cluster of upregulated genes included a group of genes classified as growth factors, cytokines and chemokines (e.g. interleukin-3, interleukin-4, B-cell growth factor 1 and stem cell growth factor) [23].
  • SCGF could disclose some human-specific mechanisms as yet unidentified from studies on the murine hematopoietic system [10].
  • Karyotypic analysis of the expanded cells from cord blood CD34(+) cells by 7-day culture with stem cell growth factor, interleukin (IL)-3, IL-6, granulocyte colony-stimulating factor, and erythropoietin was performed [24].

Analytical, diagnostic and therapeutic context of CLEC11A


  1. Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. Spritz, R.A., Giebel, L.B., Holmes, S.A. Am. J. Hum. Genet. (1992) [Pubmed]
  2. c-Kit-dependent growth of uveal melanoma cells: a potential therapeutic target? All-Ericsson, C., Girnita, L., Müller-Brunotte, A., Brodin, B., Seregard, S., Ostman, A., Larsson, O. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  3. Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation. Ito, C., Sato, H., Ando, K., Watanabe, S., Yoshiba, F., Kishi, K., Furuya, A., Shitara, K., Sugimoto, S., Kohno, H., Hiraoka, A., Hotta, T. Bone Marrow Transplant. (2003) [Pubmed]
  4. Lysophosphatidic acid-depleted serum, hepatocyte growth factor and stem cell growth factor stimulate colony growth of small cell lung cancer cells through a calcium-independent pathway. Seckl, M.J., Seufferlein, T., Rozengurt, E. Cancer Res. (1994) [Pubmed]
  5. The phagocyte 47-kilodalton cytosolic oxidase protein is an early reactant in activation of the respiratory burst. Kleinberg, M.E., Malech, H.L., Rotrosen, D. J. Biol. Chem. (1990) [Pubmed]
  6. Wnt signaling and the regulation of stem cell function. Kléber, M., Sommer, L. Curr. Opin. Cell Biol. (2004) [Pubmed]
  7. c-kit ligand: a unique potentiator of mediator release by human lung mast cells. Bischoff, S.C., Dahinden, C.A. J. Exp. Med. (1992) [Pubmed]
  8. Modulation of human platelet protein kinase C by endotoxic lipid A. Grabarek, J., Timmons, S., Hawiger, J. J. Clin. Invest. (1988) [Pubmed]
  9. Solution structure of the PX domain, a target of the SH3 domain. Hiroaki, H., Ago, T., Ito, T., Sumimoto, H., Kohda, D. Nat. Struct. Biol. (2001) [Pubmed]
  10. Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells. Hiraoka, A., Sugimura, A., Seki, T., Nagasawa, T., Ohta, N., Shimonishi, M., Hagiya, M., Shimizu, S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  11. Mutations of the KIT (mast/stem cell growth factor receptor) proto-oncogene account for a continuous range of phenotypes in human piebaldism. Spritz, R.A., Holmes, S.A., Ramesar, R., Greenberg, J., Curtis, D., Beighton, P. Am. J. Hum. Genet. (1992) [Pubmed]
  12. Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells. Bannwarth, S., Giordanengo, V., Lesimple, J., Lefebvre, J.C. J. Biol. Chem. (1998) [Pubmed]
  13. Growth factors and testicular development. Lamb, D.J. J. Urol. (1993) [Pubmed]
  14. Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils. Perrin, C., Bayle, J., Bannwarth, S., Michiels, J.F., Heudier, P., Lefebvre, J.C., Giordanengo, V. C. R. Acad. Sci. III, Sci. Vie (2001) [Pubmed]
  15. Membrane glycoproteins and platelet cytoskeleton in immune complex-induced platelet activation. Kang, J., Cabral, C., Kushner, L., Salzman, E.W. Blood (1993) [Pubmed]
  16. Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells. Hiraoka, A., Yano Ki, K., Kagami, N., Takeshige, K., Mio, H., Anazawa, H., Sugimoto, S. Hematol. J. (2001) [Pubmed]
  17. Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody. Hiraoka, A., Ohkubo, T., Fukuda, M. Cancer Res. (1987) [Pubmed]
  18. Characterization of the 47-kilodalton autosomal chronic granulomatous disease protein: tissue-specific expression and transcriptional control by retinoic acid. Rodaway, A.R., Teahan, C.G., Casimir, C.M., Segal, A.W., Bentley, D.L. Mol. Cell. Biol. (1990) [Pubmed]
  19. Activation of protein kinase C in platelets by epinephrine and A23187: correlation with fibrinogen binding. Saitoh, M., Salzman, E.W., Smith, M., Ware, J.A. Blood (1989) [Pubmed]
  20. Endotoxic lipid A interaction with human platelets. Structure-function analysis of lipid A homologs obtained from Salmonella minnesota Re595 lipopolysaccharide. Grabarek, J., Her, G.R., Reinhold, V.N., Hawiger, J. J. Biol. Chem. (1990) [Pubmed]
  21. In vitro differentiation of endothelial cells from AC133-positive progenitor cells. Gehling, U.M., Ergün, S., Schumacher, U., Wagener, C., Pantel, K., Otte, M., Schuch, G., Schafhausen, P., Mende, T., Kilic, N., Kluge, K., Schäfer, B., Hossfeld, D.K., Fiedler, W. Blood (2000) [Pubmed]
  22. Suppressive effects of recombinant human monokine induced by IFN-gamma (rHuMig) chemokine on the number of committed and primitive hemopoietic progenitors in liquid cultures of CD34+ human bone marrow cells. Schwartz, G.N., Liao, F., Gress, R.E., Farber, J.M. J. Immunol. (1997) [Pubmed]
  23. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Schmittgen, T.D., Gissel, K.A., Zakrajsek, B.A., Lawrence, B.P., Liu, Q., Jupe, E.R., Lerner, M.R., Do, S.V., Brackett, D.J. Int. J. Oncol. (2005) [Pubmed]
  24. Chromosome analysis after ex vivo expansion of CD34(+) cells from human cord blood. Katayama, Y., Miyamoto, K., Takenaka, K., Imajyo, K., Shinagawa, K., Harada, M. Cancer Genet. Cytogenet. (2001) [Pubmed]
  25. Elevated superoxide generation in mononuclear phagocytes by treatment with 1 alpha hydroxyvitamin D3: changes in kinetics and in oxidase cytosolic factor p47. Deutsch, A., Chaimovitzch, C., Nagauker-Shriker, O., Zlotnik, M., Shany, S., Levy, R. J. Am. Soc. Nephrol. (1995) [Pubmed]
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