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Chemical Compound Review

ZINC OXIDE     oxozinc

Synonyms: Zinkoxid, Nogenol, Outmine, RVPaque, Zincite, ...
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Disease relevance of ZINC OXIDE


High impact information on ZINC OXIDE

  • CONCLUSIONS: Zinc oxide welding fume was associated with a marked dose-dependent increase in the number of polymorphonuclear leukocytes recovered in bronchoalveolar lavage fluid 22 hours after exposure but was not associated with a clinically significant change in pulmonary function or airway reactivity [5].
  • Detailed XRD, TEM, and Raman studies prove that, with the exception of the iron oxide system, where a mixture of the two phases magnetite and maghemite is formed, only phase pure materials are obtained, gamma-Ga(2)O(3), zincite ZnO, and cubic In(2)O(3) [6].
  • RATIONALE: Zinc oxide is a common, biologically active constituent of particulate air pollution as well as a workplace toxin [7].
  • Reactions on a solid surface. A simple, economical and efficient Friedel-Crafts acylation reaction over zinc oxide (ZnO) as a new catalyst [8].
  • Snow-white duodenum: a new endoscopic sign in a patient with hypobetalipoproteinemia [9].

Biological context of ZINC OXIDE

  • Commercial sources of zinc oxide (ZnO) differ widely in Zn relative bioavailability (RBV), but it is unknown whether growth-promoting efficacy in young pigs is influenced by RBV of the ZnO sources used [10].
  • 1. The OPAE random primers (Operon Technologies, Inc., CA) were used for random amplified polymorphic DNA (RAPD) fingerprinting in Chinese, White Roman and Landaise geese [11].
  • Zinc oxide inhalation causes metal fume fever, a flu-like syndrome common among welders [12].
  • Occupational exposure to freshly formed zinc oxide (ZnO) particles (less than 1.0 micron aerodynamic diameter) produces a well-characterized response known as metal fume fever [13].
  • Zinc oxide was selected to control the reactivity of the glass-ceramics since zinc is a trace element that shows stimulatory effects on bone formation [14].

Anatomical context of ZINC OXIDE


Associations of ZINC OXIDE with other chemical compounds


Gene context of ZINC OXIDE


Analytical, diagnostic and therapeutic context of ZINC OXIDE

  • Zinc oxide was not associated with increased pain by the visual analog scale, cellular abnormalities by histopathological examination of wound biopsies, or other harmful effects [25].
  • On the basis of the study results, it may be concluded that Nogenol appears to be more appropriate for cementation of both 2- and 4-implant-supported FPDs when removal of the provisionally cemented superstructure is anticipated [26].
  • Piezoelectric thin film zinc oxide (ZnO) and its ternary alloy magnesium zinc oxide (MgxZn1-xO) have broad applications in transducers, resonators, and filters [27].
  • Zinc oxide installed in the tissue cages created high, sustained concentrations of zinc in the cage fluid throughout the study [28].
  • CONCLUSIONS: Under the conditions of the present study, Snow-White impression plaster appears to be safer to use in implant prosthodontics compared with the Xantano because of its slower and lower exothermic reaction at the implant-bone interface [29].


  1. Zinc oxide protects cultured enterocytes from the damage induced by Escherichia coli. Roselli, M., Finamore, A., Garaguso, I., Britti, M.S., Mengheri, E. J. Nutr. (2003) [Pubmed]
  2. Biometry and primary angle-closure glaucoma among Chinese, white, and black populations. Congdon, N.G., Youlin, Q., Quigley, H., Hung, P.T., Wang, T.H., Ho, T.C., Tielsch, J.M. Ophthalmology (1997) [Pubmed]
  3. Pulmonary clearance and toxicity of zinc oxide instilled into the rat lung. Hirano, S., Higo, S., Tsukamoto, N., Kobayashi, E., Suzuki, K.T. Arch. Toxicol. (1989) [Pubmed]
  4. Comparative eco-toxicity of nanoscale TiO(2), SiO(2), and ZnO water suspensions. Adams, L.K., Lyon, D.Y., Alvarez, P.J. Water Res. (2006) [Pubmed]
  5. An experimental human model of metal fume fever. Blanc, P., Wong, H., Bernstein, M.S., Boushey, H.A. Ann. Intern. Med. (1991) [Pubmed]
  6. A general nonaqueous route to binary metal oxide nanocrystals involving a C-C bond cleavage. Pinna, N., Garnweitner, G., Antonietti, M., Niederberger, M. J. Am. Chem. Soc. (2005) [Pubmed]
  7. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Beckett, W.S., Chalupa, D.F., Pauly-Brown, A., Speers, D.M., Stewart, J.C., Frampton, M.W., Utell, M.J., Huang, L.S., Cox, C., Zareba, W., Oberdörster, G. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  8. Reactions on a solid surface. A simple, economical and efficient Friedel-Crafts acylation reaction over zinc oxide (ZnO) as a new catalyst. Sarvari, M.H., Sharghi, H. J. Org. Chem. (2004) [Pubmed]
  9. Snow-white duodenum: a new endoscopic sign in a patient with hypobetalipoproteinemia. Mitchell, C.J., Scott, B.B., Bullen, A.W., Losowsky, M.S. Gastrointest. Endosc. (1978) [Pubmed]
  10. Growth-promoting efficacy in young pigs of two sources of zinc oxide having either a high or a low bioavailability of zinc. Mavromichalis, I., Peter, C.M., Parr, T.M., Ganessunker, D., Baker, D.H. J. Anim. Sci. (2000) [Pubmed]
  11. Female-specific DNA sequences in geese. Huang, M.C., Lin, W.C., Horng, Y.M., Rouvier, R., Huang, C.W. Br. Poult. Sci. (2003) [Pubmed]
  12. Early pulmonary cytokine responses to zinc oxide fume inhalation. Kuschner, W.G., D'Alessandro, A., Wong, H., Blanc, P.D. Environmental research. (1997) [Pubmed]
  13. Pulmonary effects of inhaled zinc oxide in human subjects, guinea pigs, rats, and rabbits. Gordon, T., Chen, L.C., Fine, J.M., Schlesinger, R.B., Su, W.Y., Kimmel, T.A., Amdur, M.O. American Industrial Hygiene Association journal. (1992) [Pubmed]
  14. Effect of ZnO addition on bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics containing apatite and wollastonite. Kamitakahara, M., Ohtsuki, C., Inada, H., Tanihara, M., Miyazaki, T. Acta biomaterialia. (2006) [Pubmed]
  15. X-ray absorption fine structure analysis of the local environment of zinc in dentine treated with zinc compounds. Takatsuka, T., Hirano, J., Matsumoto, H., Honma, T. Eur. J. Oral Sci. (2005) [Pubmed]
  16. The effect of human blood on the sealing ability of root canal sealers: an in vitro study. Negm, M.M. Oral Surg. Oral Med. Oral Pathol. (1989) [Pubmed]
  17. Effect of root canal sealers and irrigation agents on retention of preformed posts luted with a resin cement. Mayhew, J.T., Windchy, A.M., Goldsmith, L.J., Gettleman, L. Journal of endodontics. (2000) [Pubmed]
  18. Biocompatibility of various formula root filling materials for primary teeth. Huang, T.H., Ding, S.J., Kao, C.T. J. Biomed. Mater. Res. Part B Appl. Biomater. (2007) [Pubmed]
  19. A mixture of Ca(OH)2 paste and ZnO powder as a root canal filling material for primary teeth: a preliminary study. Chawla, H.S., Mathur, V.P., Gauba, K., Goyal, A. Journal of the Indian Society of Pedodontics and Preventive Dentistry. (2001) [Pubmed]
  20. Tumor necrosis factor-alpha and interleukin-8 release from U937 human mononuclear cells exposed to zinc oxide in vitro. Mechanistic implications for metal fume fever. Kuschner, W.G., D'Alessandro, A., Hambleton, J., Blanc, P.D. J. Occup. Environ. Med. (1998) [Pubmed]
  21. Effect of phosphorylated mannans and pharmacological additions of zinc oxide on growth and immunocompetence of weanling pigs. Davis, M.E., Brown, D.C., Maxwell, C.V., Johnson, Z.B., Kegley, E.B., Dvorak, R.A. J. Anim. Sci. (2004) [Pubmed]
  22. Influence of cooking practice on antioxidant properties and phenolic content of selected vegetables. Ismail, A., Lee, W.Y. Asia Pacific journal of clinical nutrition. (2004) [Pubmed]
  23. Comparison of APF activity and epithelial growth factor levels in urine from Chinese, African-American, and white American patients with interstitial cystitis. u Zhang, C.O., Li, Z.L., Shoenfelt, J.L., Kong, C.Z., Chai, T.C., Erickson, D.R., Peters, K.M., Rovner, E.S., Keay, S. Urology (2003) [Pubmed]
  24. The effect of topically applied corticosteroids and zinc on the metallothionein content of skin in an experimental model. Frings, M.M., Kind, P.P., Goerz, G., Abel, J. Clin. Exp. Dermatol. (1989) [Pubmed]
  25. A randomized, double-blind, placebo-controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision. Agren, M.S., Ostenfeld, U., Kallehave, F., Gong, Y., Raffn, K., Crawford, M.E., Kiss, K., Friis-M??ller, A., Gluud, C., Jorgensen, L.N. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (2006) [Pubmed]
  26. Cement failure loads of 4 provisional luting agents used for the cementation of implant-supported fixed partial dentures. Michalakis, K.X., Pissiotis, A.L., Hirayama, H. The International journal of oral & maxillofacial implants. (2000) [Pubmed]
  27. Characteristics of MgxZn1-xO thin film bulk acoustic wave devices. Wittstruck, R.H., Tong, X., Emanetoglu, N.W., Wu, P., Chen, Y., Zhu, J., Muthukumar, S., Lu, Y., Ballato, A. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. (2003) [Pubmed]
  28. The effect of zinc oxide on Staphylococcus aureus and polymorphonuclear cells in a tissue cage model. Sunzel, B., Lasek, J., Söderberg, T., Elmros, T., Hallmans, G., Holm, S. Scandinavian journal of plastic and reconstructive surgery and hand surgery / Nordisk plastikkirurgisk forening [and] Nordisk klubb for handkirurgi. (1990) [Pubmed]
  29. Heat transfer of impression plasters to an implant-bone interface. Nissan, J., Gross, M., Ormianer, Z., Barnea, E., Assif, D. Implant dentistry. (2006) [Pubmed]
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