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Gene Review

Tns  -  tensin

Rattus norvegicus

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Disease relevance of Tns


High impact information on Tns


Biological context of Tns


Anatomical context of Tns


Associations of Tns with chemical compounds

  • Studying the quantitative relationships between the various components of the submembrane plaque indicated that the levels of vinculin, paxillin and phosphotyrosine in adhesion sites are positively correlated with each other and negatively correlated with the levels of tensin [15].
  • Tensin-rich fibrillar adhesions were relatively insensitive to H-7 treatment [15].
  • The results revealed tonin's new capability of forming kinin in addition to the hitherto known pressor angiotensin II, indicating tonin, too, is a member of the "kinin- tensin enzyme system."[16]
  • Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats [17].
  • PTEN (phosphatase and tensin homolog) and pPTEN were expressed but not different in aorta from DOCA-salt and sham rats [18].

Enzymatic interactions of Tns


Other interactions of Tns


Analytical, diagnostic and therapeutic context of Tns


  1. Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: a potential role for phosphatase and tensin homolog deleted on chromosome ten? Mensah, K., Mocanu, M.M., Yellon, D.M. J. Am. Coll. Cardiol. (2005) [Pubmed]
  2. Adhesion-induced tyrosine phosphorylation of the p130 src substrate. Petch, L.A., Bockholt, S.M., Bouton, A., Parsons, J.T., Burridge, K. J. Cell. Sci. (1995) [Pubmed]
  3. Absence of PTEN/MMAC1 gene mutations in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Cancer Lett. (2001) [Pubmed]
  4. Inhibition of neuronal phenotype by PTEN in PC12 cells. Musatov, S., Roberts, J., Brooks, A.I., Pena, J., Betchen, S., Pfaff, D.W., Kaplitt, M.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  5. Tensin: a potential link between the cytoskeleton and signal transduction. Lo, S.H., Weisberg, E., Chen, L.B. Bioessays (1994) [Pubmed]
  6. Paxillin is tyrosine-phosphorylated by and preferentially associates with the calcium-dependent tyrosine kinase in rat liver epithelial cells. Li, X., Earp, H.S. J. Biol. Chem. (1997) [Pubmed]
  7. Cell spreading on extracellular matrix proteins induces tyrosine phosphorylation of tensin. Bockholt, S.M., Burridge, K. J. Biol. Chem. (1993) [Pubmed]
  8. Gene expression profiling identifies a unique androgen-mediated inflammatory/immune signature and a PTEN (phosphatase and tensin homolog deleted on chromosome 10)-mediated apoptotic response specific to the rat ventral prostate. Desai, K.V., Michalowska, A.M., Kondaiah, P., Ward, J.M., Shih, J.H., Green, J.E. Mol. Endocrinol. (2004) [Pubmed]
  9. Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Omori, N., Jin, G., Li, F., Zhang, W.R., Wang, S.J., Hamakawa, Y., Nagano, I., Manabe, Y., Shoji, M., Abe, K. Brain Res. (2002) [Pubmed]
  10. Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. Di Lisa, F., De Tullio, R., Salamino, F., Barbato, R., Melloni, E., Siliprandi, N., Schiaffino, S., Pontremoli, S. Biochem. J. (1995) [Pubmed]
  11. Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt. Cartel, N.J., Wang, J., Post, M. Biochem. J. (2002) [Pubmed]
  12. Dietary exposure to whey proteins alters rat mammary gland proliferation, apoptosis, and gene expression during postnatal development. Eason, R.R., Velarde, M.C., Chatman, L., Till, S.R., Geng, Y., Ferguson, M., Badger, T.M., Simmen, R.C. J. Nutr. (2004) [Pubmed]
  13. Tensin is expressed in glomerular mesangial cells and is related to their attachment to surrounding extracellular matrix. Takahara, H., Shirato, I., Asanuma, K., Yamashita, M., Takeda, Y., Tomino, Y. J. Histochem. Cytochem. (2004) [Pubmed]
  14. Phosphorylation of PTEN and Akt in astrocytes of the rat hippocampus following transient forebrain ischemia. Choi, J.S., Park, H.J., Kim, H.Y., Kim, S.Y., Lee, J.E., Choi, Y.S., Chun, M.H., Chung, J.W., Lee, M.Y. Cell Tissue Res. (2005) [Pubmed]
  15. Molecular diversity of cell-matrix adhesions. Zamir, E., Katz, B.Z., Aota, S., Yamada, K.M., Geiger, B., Kam, Z. J. Cell. Sci. (1999) [Pubmed]
  16. Kininogenase activity of tonin. Ikeda, M., Arakawa, K. Hypertension (1984) [Pubmed]
  17. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. Lee, J.H., Kim, K.Y., Lee, Y.K., Park, S.Y., Kim, C.D., Lee, W.S., Rhim, B.Y., Hong, K.W. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
  18. Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Northcott, C.A., Poy, M.N., Najjar, S.M., Watts, S.W. Circ. Res. (2002) [Pubmed]
  19. Abnormal PTEN expression in portal hypertensive gastric mucosa: a key to impaired PI 3-kinase/Akt activation and delayed injury healing? Tsugawa, K., Jones, M.K., Akahoshi, T., Moon, W.S., Maehara, Y., Hashizume, M., Sarfeh, I.J., Tarnawski, A.S. FASEB J. (2003) [Pubmed]
  20. Initial signaling of the fibronectin receptor (alpha5beta1 integrin) in hepatic stellate cells is independent of tyrosine phosphorylation. Milliano, M.T., Luxon, B.A. J. Hepatol. (2003) [Pubmed]
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