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Gene Review

PAM16  -  presequence translocase-associated motor...

Homo sapiens

Synonyms: CGI-136, MAGMAS, Magmas, Mitochondria-associated granulocyte macrophage CSF-signaling molecule, Mitochondrial import inner membrane translocase subunit TIM16, ...
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Disease relevance of Magmas

  • The results indicated that Magmas expression in prostate cancer is heterogeneous and independent of clinical stage and Gleason score [1].
  • Approximately one half of the adenocarcinoma samples examined had weak Magmas expression, while the remainder had intermediate to high levels [1].

High impact information on Magmas

  • Enhanced mantle-to-crust rhenium transfer in undegassed arc magmas [2].
  • But most volatile elements have very low solubilities in magmas at atmospheric pressure, and therefore virtually all erupted lavas are degassed and do not retain their primary volatile signatures [3].
  • Here we report a rare case in which olivine (with 93.3% forsterite; Mg2SiO4) phenocrysts, precipitated from an unerupted komatiitic melt (approximately 24% MgO) of the Tristan mantle plume head 132 Myr ago, were carried to upper-crust levels in northwest Namibia by less Mg-rich (9.6-18.5% MgO) magmas [4].
  • Tim14 forms a complex with the J-like protein Tim16 [5].
  • Because GM-CSF receptor levels are elevated in prostate cancer, Magmas expression was examined in normal and neoplastic tissue [1].

Anatomical context of Magmas


Associations of Magmas with chemical compounds

  • Unlike their arc-related counterparts, however, the Chinese magmas carry inherited Archaean zircons and have neodymium and strontium isotopic compositions overlapping those of eclogite xenoliths derived from the lower crust of the North China craton [6].
  • Relatively undifferentiated failing rift magmas must have relatively short crustal residence times prior to eruption and, therefore, have not undergone significant degassing of CO2, as would appear to be the case for the more highly fractionated propagating rift magmas [7].

Other interactions of Magmas

  • We further demonstrate tight regulation of the cochaperone activity of Tim14 by Tim16 [5].
  • Our modelling shows that more than half of Hawaiian magmas formed during the past 1 Myr came from this source [8].
  • Modern slab melts are thus unlike Archean Trondhjemite-Tonalite-Granodiorite rocks (TTG), which suggests that both types of magmas were generated via different petrogenetic pathways which may imply an Archean tectonic model of crust production different from that of the present-day, subduction-related, one [9].

Analytical, diagnostic and therapeutic context of Magmas


  1. Magmas expression in neoplastic human prostate. Jubinsky, P.T., Short, M.K., Mutema, G., Morris, R.E., Ciraolo, G.M., Li, M. J. Mol. Histol. (2005) [Pubmed]
  2. Enhanced mantle-to-crust rhenium transfer in undegassed arc magmas. Sun, W., Bennett, V.C., Eggins, S.M., Kamenetsky, V.S., Arculus, R.J. Nature (2003) [Pubmed]
  3. Vapour undersaturation in primitive mid-ocean-ridge basalt and the volatile content of Earth's upper mantle. Saal, A.E., Hauri, E.H., Langmuir, C.H., Perfit, M.R. Nature (2002) [Pubmed]
  4. Transient high temperatures in mantle plume heads inferred from magnesian olivines in Phanerozoic picrites. Thompson, R.N., Gibson, S.A. Nature (2000) [Pubmed]
  5. Structure and function of Tim14 and Tim16, the J and J-like components of the mitochondrial protein import motor. Mokranjac, D., Bourenkov, G., Hell, K., Neupert, W., Groll, M. EMBO J. (2006) [Pubmed]
  6. Recycling lower continental crust in the North China craton. Gao, S., Rudnick, R.L., Yuan, H.L., Liu, X.M., Liu, Y.S., Xu, W.L., Ling, W.L., Ayers, J., Wang, X.C., Wang, Q.H. Nature (2004) [Pubmed]
  7. C-O-H ratios of silicate melt inclusions in basalts from the Galapagos Spreading Center near 95 degrees W: a laser decrepitation mass spectrometry study. Yonover, R.N., Sinton, J.M., Sommer, M.A., Gibson, E.K. Geochim. Cosmochim. Acta (1989) [Pubmed]
  8. An olivine-free mantle source of Hawaiian shield basalts. Sobolev, A.V., Hofmann, A.W., Sobolev, S.V., Nikogosian, I.K. Nature (2005) [Pubmed]
  9. Oceanic slab melting and mantle metasomatism. Scaillet, B., Prouteau, G. Science progress. (2001) [Pubmed]
  10. Release of gold-bearing fluids in convergent margin magmas prompted by magnetite crystallization. Sun, W., Arculus, R.J., Kamenetsky, V.S., Binns, R.A. Nature (2004) [Pubmed]
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