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Chemical Compound Review

RHENIUM     rhenium

Synonyms: AG-G-95693, ACMC-20ajsu, CHEBI:49882, KST-1A2130, KST-1A2131, ...
 
 
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Disease relevance of rhenium

 

Psychiatry related information on rhenium

 

High impact information on rhenium

  • Enhanced mantle-to-crust rhenium transfer in undegassed arc magmas [6].
  • Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals [7].
  • The biodistribution data clearly demonstrate that both rhenium cyclization and D-Lys incorporation enhanced the tumor localization and retention of the radiolabel [3].
  • The PLACORHEN study: a double-blind, placebo-controlled, randomized radionuclide study with (186)Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study [8].
  • Particle size analysis of (99m)Tc-labeled and unlabeled antimony trisulfide and rhenium sulfide colloids intended for lymphoscintigraphic application [9].
 

Chemical compound and disease context of rhenium

 

Biological context of rhenium

  • RESULTS: P748 peptide inhibited the aggregation of human platelets in PRP by 50% at a concentration (IC50) of 28 nM and [ReO]P748 had an IC50 of 36 nM showing the high in vitro receptor binding affinity of both the peptide and its rhenium complex (and by analogy its technetium complex) [15].
  • The reaction kinetics and mechanisms of catalytic oxygen atom transfer (OAT) with rhenium oxazoline and thiazoline complexes are described in this feature article [16].
  • A new hexanuclear rhenium cluster encapsulated by six iridium complexes, [Re6Te8(CN)6][(Ir(CO)(PPh3)2)6](OTf)2 (3), which is effective in catalyzing the hydrogenation of p-CH3C6H4C[triple bond]CH to p-CH3C6H4CH=CH2 has been prepared [17].
  • Resonance energy transfer study using a rhenium metal-ligand lipid conjugate as the donor in a model membrane [18].
  • Our results show that rhenium complexes with two available coordination sites interact with plasmid DNA to form a stable adduct that is likely to involve two bases [19].
 

Anatomical context of rhenium

  • Rhenium conjugation utilized the antibody RS7, the target cell line ME180 and three of the other radiolabels were also tested with this antibody-target cell combination for comparison [20].
  • An evaluation of the mediastinal lymphoscintigram for carcinoma of the esophagus studied with 99mTc rhenium sulfur colloid [21].
  • METHODS AND MATERIALS: Rhenium glass microspheres were made radioactive by neutron activation and then injected into the hepatic artery of Sprague-Dawley rats containing 1-week-old Novikoff hepatomas [22].
  • Lymphoscintigraphies were performed on the day before surgery to visualize sentinel lymph nodes, 31 +/- 22.5 and 174 +/- 34 min after injection of 200 microCi of technetium 99m rhenium sulfur colloid [23].
  • The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37 degrees C. Therapeutic radioactive rhenium activities can be obtained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 x 10(13) cm(-2)s(-1) [24].
 

Associations of rhenium with other chemical compounds

  • This study used technetium-99m colloidal rhenium sulphide with a mean particle size of 100 (range 50-200) nm for sentinel node mapping [12].
  • The 1,3-isomerization of allylic alcohol 10 was accomplished via rhenium oxo catalysis and has been applied successfully in the synthesis [25].
  • The Tc-99m complexes revealed good inertness against ligand exchange (Cys and His) and excellent stability in physiological buffered saline as well as in human plasma over a period of 24 h at 37 degrees C. The rhenium complexes have been tested for competitive inhibition of the (yeast) hexokinase [26].
  • Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase [26].
  • Thus, we have developed a novel method that allows any currently used stainless steel or tantalum stent to be coated with radioactive rhenium [27].
 

Gene context of rhenium

  • The use of rhenium or indium radiolabels for therapy may provide a new approach to GRP/bombesin expressing tumours [28].
  • Eight patients (77 joints) with polyarthritis were treated systemically with 570 MBq (15.4 mCi) of rhenium 186 ((186)Re) hydroxyethylidenediphosphonate (HEDP) [29].
  • Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy [10].
  • Management of postsurgical recurrence of hepatocellular carcinoma with rhenium 188-HDD labeled iodized oil [30].
  • Functionalization of polyoxometalates: from Lindqvist to Keggin derivatives. 1. synthesis, solution studies, and spectroscopic and ESI mass spectrometry characterization of the rhenium phenylimido tungstophosphate [PW11O39(ReNC6H5)]4- [31].
 

Analytical, diagnostic and therapeutic context of rhenium

  • Electrospray ionization mass spectrometry (ESI-MS) and collision experiments (MS/MS) represent valuable analytical techniques suitable for the characterization of both technetium and rhenium complexes relevant to NM [7].
  • Despite the multiple stereoisomers that could arise from tetradentate ligation of salen ligands to rhenium, one major isomer is observed and isolated in each instant [32].
  • The identity of [99mTc](SNS/S) complexes is established by high-performance liquid chromatographic (HPLC) comparison with authentic rhenium samples [33].
  • PURPOSE: To evaluate a self-expanding rhenium 188 (188Re) radiochemically labeled radioactive stent in sheep [34].
  • The stability of reduced rhenium against pH change from 2 to 5.5 and against dilution of rhenium in the reaction mixture to the concentration suitable for the application in radiotherapy were studied as well [35].

References

  1. Transplantation-related toxicity and acute intestinal graft-versus-host disease after conditioning regimens intensified with Rhenium 188-labeled anti-CD66 monoclonal antibodies. Klein, S.A., Hermann, S., Dietrich, J.W., Hoelzer, D., Martin, H. Blood (2002) [Pubmed]
  2. Rhenium 188-labeled anti-CD66 (a, b, c, e) monoclonal antibody to intensify the conditioning regimen prior to stem cell transplantation for patients with high-risk acute myeloid leukemia or myelodysplastic syndrome: results of a phase I-II study. Bunjes, D., Buchmann, I., Duncker, C., Seitz, U., Kotzerke, J., Wiesneth, M., Dohr, D., Stefanic, M., Buck, A., Harsdorf, S.V., Glatting, G., Grimminger, W., Karakas, T., Munzert, G., Döhner, H., Bergmann, L., Reske, S.N. Blood (2001) [Pubmed]
  3. Radioiodination of rhenium cyclized alpha-melanocyte-stimulating hormone resulting in enhanced radioactivity localization and retention in melanoma. Cheng, Z., Chen, J., Quinn, T.P., Jurisson, S.S. Cancer Res. (2004) [Pubmed]
  4. Synthesis, characterization, and biological evaluation of M(I)(CO)3(NNO) complexes (M = Re, 99mTc) conjugated to 2-(4-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals. Tzanopoulou, S., Pirmettis, I.C., Patsis, G., Paravatou-Petsotas, M., Livaniou, E., Papadopoulos, M., Pelecanou, M. J. Med. Chem. (2006) [Pubmed]
  5. Synthesis and amyloid binding properties of rhenium complexes: preliminary progress toward a reagent for SPECT imaging of Alzheimer's disease brain. Zhen, W., Han, H., Anguiano, M., Lemere, C.A., Cho, C.G., Lansbury, P.T. J. Med. Chem. (1999) [Pubmed]
  6. Enhanced mantle-to-crust rhenium transfer in undegassed arc magmas. Sun, W., Bennett, V.C., Eggins, S.M., Kamenetsky, V.S., Arculus, R.J. Nature (2003) [Pubmed]
  7. Contribution of electrospray mass spectrometry for the characterization, design, and development of nitrido technetium and rhenium heterocomplexes as potential radiopharmaceuticals. Tisato, F., Bolzati, C., Porchia, M., Refosco, F. Mass spectrometry reviews. (2004) [Pubmed]
  8. The PLACORHEN study: a double-blind, placebo-controlled, randomized radionuclide study with (186)Re-etidronate in hormone-resistant prostate cancer patients with painful bone metastases. Placebo Controlled Rhenium Study. Han, S.H., de Klerk, J.M., Tan, S., van het Schip, A.D., Derksen, B.H., van Dijk, A., Kruitwagen, C.L., Blijham, G.H., van Rijk, P.P., Zonnenberg, B.A. J. Nucl. Med. (2002) [Pubmed]
  9. Particle size analysis of (99m)Tc-labeled and unlabeled antimony trisulfide and rhenium sulfide colloids intended for lymphoscintigraphic application. Tsopelas, C. J. Nucl. Med. (2001) [Pubmed]
  10. Novel Tat-peptide chelates for direct transduction of technetium-99m and rhenium into human cells for imaging and radiotherapy. Polyakov, V., Sharma, V., Dahlheimer, J.L., Pica, C.M., Luker, G.D., Piwnica-Worms, D. Bioconjug. Chem. (2000) [Pubmed]
  11. Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer (Br J Surg 2001; 88: 704-7). Rogers, C., Azmy, I.A. The British journal of surgery. (2001) [Pubmed]
  12. Sentinel node biopsy with technetium-99m colloidal rhenium sulphide in patients with breast cancer. Watanabe, T., Kimijima, I., Ohtake, T., Tsuchiya, A., Shishido, F., Takenoshita, S. The British journal of surgery. (2001) [Pubmed]
  13. Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors. Bigott, H.M., Parent, E., Luyt, L.G., Katzenellenbogen, J.A., Welch, M.J. Bioconjug. Chem. (2005) [Pubmed]
  14. Radionuclide therapy for prostate cancer lumbar metastasis prolongs symptom-free survival in a rat model. Geldof, A.A., van den Tillaar, P.L., Newling, D.W., Teule, G.J. Urology (1997) [Pubmed]
  15. Pre-clinical evaluation of technetium-99m platelet receptor-binding peptide. Lister-James, J., Vallabhajosula, S., Moyer, B.R., Pearson, D.A., McBride, B.J., De Rosch, M.A., Bush, L.R., Machac, J., Dean, R.T. J. Nucl. Med. (1997) [Pubmed]
  16. Swift oxo transfer reactions of perchlorate and other substrates catalyzed by rhenium oxazoline and thiazoline complexes. Abu-Omar, M.M. Chem. Commun. (Camb.) (2003) [Pubmed]
  17. [Re6Te8(CN)6][(Ir(CO)(PPh3)2)6](OTf)2 : a new Re6 cluster-supported iridium(I) compound. Kim, Y., Kim, S., Kim, S.J., Lee, M.K., Kim, M., Lee, H., Chin, C.S. Chem. Commun. (Camb.) (2004) [Pubmed]
  18. Resonance energy transfer study using a rhenium metal-ligand lipid conjugate as the donor in a model membrane. Li, L., Gryczynski, I., Lakowicz, J.R. Chem. Phys. Lipids (1999) [Pubmed]
  19. Guanine and plasmid DNA binding of mono- and trinuclear fac-[Re(CO)3]+ complexes with amino acid ligands. Zobi, F., Spingler, B., Alberto, R. Chembiochem (2005) [Pubmed]
  20. The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels. Shih, L.B., Thorpe, S.R., Griffiths, G.L., Diril, H., Ong, G.L., Hansen, H.J., Goldenberg, D.M., Mattes, M.J. J. Nucl. Med. (1994) [Pubmed]
  21. An evaluation of the mediastinal lymphoscintigram for carcinoma of the esophagus studied with 99mTc rhenium sulfur colloid. Terui, S., Kato, H., Hirashima, T., Iizuka, T., Oyamada, H. European journal of nuclear medicine. (1982) [Pubmed]
  22. Hepatic tumor radioembolization in a rat model using radioactive rhenium (186Re/188Re) glass microspheres. Häfeli, U.O., Casillas, S., Dietz, D.W., Pauer, G.J., Rybicki, L.A., Conzone, S.D., Day, D.E. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  23. Laparoscopic identification of sentinel lymph nodes in early stage cervical cancer: prospective study using a combination of patent blue dye injection and technetium radiocolloid injection. Lambaudie, E., Collinet, P., Narducci, F., Sonoda, Y., Papageorgiou, T., Carpentier, P., Leblanc, E., Querleu, D. Gynecol. Oncol. (2003) [Pubmed]
  24. Preparation and properties of radioactive rhenium glass microspheres intended for in vivo radioembolization therapy. Conzone, S.D., Häfeli, U.O., Day, D.E., Ehrhardt, G.J. J. Biomed. Mater. Res. (1998) [Pubmed]
  25. Synthetic studies on amphidinolide B1. Mandal, A.K., Schneekloth, J.S., Kuramochi, K., Crews, C.M. Org. Lett. (2006) [Pubmed]
  26. Synthesis and in vitro characterization of organometallic rhenium and technetium glucose complexes against Glut 1 and hexokinase. Schibli, R., Dumas, C., Petrig, J., Spadola, L., Scapozza, L., Garcia-Garayoa, E., Schubiger, P.A. Bioconjug. Chem. (2005) [Pubmed]
  27. Electrodeposition of radioactive rhenium onto stents to prevent restenosis. Häfeli, U.O., Warburton, M.C., Landau, U. Biomaterials (1998) [Pubmed]
  28. Is there a role for agonist gastrin-releasing peptide receptor radioligands in tumour imaging? Van de Wiele, C., Dumont, F., van Belle, S., Slegers, G., Peers, S.H., Dierckx, R.A. Nuclear medicine communications. (2001) [Pubmed]
  29. Painful multifocal arthritis: therapy with rhenium 186 hydroxyethylidenediphosphonate ((186)Re HEDP) after failed treatment with medication--initial results of a prospective study. Palmedo, H., Rockstroh, J.K., Bangard, M., Schliefer, K., Risse, J., Menzel, C., Biersack, H.J. Radiology. (2001) [Pubmed]
  30. Management of postsurgical recurrence of hepatocellular carcinoma with rhenium 188-HDD labeled iodized oil. Kumar, A., Srivastava, D.N., Bal, C. Journal of vascular and interventional radiology : JVIR. (2006) [Pubmed]
  31. Functionalization of polyoxometalates: from Lindqvist to Keggin derivatives. 1. synthesis, solution studies, and spectroscopic and ESI mass spectrometry characterization of the rhenium phenylimido tungstophosphate [PW11O39(ReNC6H5)]4-. Dablemont, C., Proust, A., Thouvenot, R., Afonso, C., Fournier, F., Tabet, J.C. Inorganic chemistry. (2004) [Pubmed]
  32. Synthesis of Cationic Rhenium(VII) Oxo Imido Complexes and Their Tunability Towards Oxygen Atom Transfer. Ison, E.A., Cessarich, J.E., Travia, N.E., Fanwick, P.E., Abu-Omar, M.M. J. Am. Chem. Soc. (2007) [Pubmed]
  33. Glutathione-mediated metabolism of technetium-99m SNS/S mixed ligand complexes: a proposed mechanism of brain retention. Nock, B.A., Maina, T., Yannoukakos, D., Pirmettis, I.C., Papadopoulos, M.S., Chiotellis, E. J. Med. Chem. (1999) [Pubmed]
  34. Inhibition of neointimal proliferation with 188Re-labeled self-expanding nitinol stent in a sheep model. Meyer, J.M., Nowak, B., Schuermann, K., Buecker, A., Moltzahn, F., Kulisch, A., Heussen, N., Görgen, T., Büll, U., Günther, R.W. Radiology. (2003) [Pubmed]
  35. Study of perrhenate reduction by capillary electrophoresis. Kohlícková-Koudelková, M., Jedináková-Krízová, V., Deyl, Z. Electrophoresis (2002) [Pubmed]
 
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