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Gene Review

TCTN1  -  tectonic family member 1

Homo sapiens

Synonyms: FLJ21127, JBTS13, TECT1, Tectonic-1, UNQ9369/PRO34160
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Disease relevance of TECT1

  • Tectonic corneal lamellar grafting for severe scleral melting after pterygium surgery [1].
  • Management was complicated by loss of tectonic integrity that followed scleral flap necrosis, by impaired vitreoretinal visualization associated with rapidly progressive sclerokeratitis or keratitis, and by bacterial scleritis in the base of the scleral flap [2].
  • CONCLUSIONS: These results indicate that PK may be performed for tectonic reasons, but prospects for restoration of sight in patients with advanced cicatrizing conjunctival diseases, even after extensive preoperative medical and surgical therapy, are limited [3].
  • OBJECTIVE: To report on frequency, time of occurrence, treatment, and final outcome of rhegmatogenous retinal detachment after block excision, combined with corneoscleral tectonic grafts, of intraocular epithelial implantation cysts and tumors of the anterior uvea involving the anterior chamber angle [4].
  • Tectonic keratoplasty for peripheral ulcerative keratitis [5].

High impact information on TECT1

  • Theoretical models of mantle flow have been used to infer that, for progressive simple shear imparted by the motion of an overriding tectonic plate, the a-axes of olivine crystals should align themselves parallel to the direction of plate motion [6].
  • Uplift to the north of the Val Verde basin between 310 and 280 Myr ago appears to be the only tectonic event with appropriate timing and location to be the source of the magmatic CO2 [7].
  • Suggestions have ranged from volcanic eruptions of liquid water or solid ice to tectonic deformation, but definitive high-resolution morphological evidence has been lacking [8].
  • Evidence is presented here in support of the hypothesis that heightened hydrothermal activity induced by the Eocene tectonic activity caused a global greenhouse effect, which may represent the long-sought-after historical analog to the carbon dioxide-induced global warming expected to occur by the middle of the next century [9].
  • Repeated tectonic collisions may be one of the most important phenomena promoting continental biodiversity [10].

Biological context of TECT1

  • Molecular phylogeny of osteoglossoids: a new model for Gondwanian origin and plate tectonic transportation of the Asian arowana [11].
  • Haplotype diversity was relatively low in Ponto-Caspian drainages relative to more stable tectonic lakes in Greece, Macedonia, and Turkey [12].
  • In contrast, geographically isolated tectonic lake populations exhibited relatively high levels of genetic diversity (theta = 0.0032 to 0.0134) [13].
  • All patients were investigated by a new PAP smear, histology, and two commercially available HPV tests: Hybrid Capture II (Digene, Gaithersburg, MD) and the Pre Tect HPV-Proofer (NorChip AS) [14].
  • Recurrence rates, tectonic outcomes, pre- and postoperative visual acuities, and complications were analyzed [15].

Anatomical context of TECT1

  • PURPOSE: This study describes the authors' surgical technique and the results in 68 consecutive patients with tumors of the iris and ciliary body involving the angle removed by block excision and tectonic corneoscleral grafting between 1980 and 1995 [16].
  • RESULTS: Sixteen (80%) of 20 cases developed severe scleral necrosis that required tectonic surgery after bare sclera pterygium excision with mitomycin C or beta-irradiation [1].
  • INTERVENTION: Penetrating tectonic keratoplasty with excimer laser trephination was performed along metal aperture masks in donor and recipient corneas [17].
  • "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy [18].
  • Histological analysis of hippocampi removed en bloc during surgical treatment of temporal lobe epilepsy revealed a subgroup of patients with bulbous expansions of the CA1 pyramidal cell/subicular layers that were consistently accompanied by "tectonic" invaginations of the adjacent dentate gyrus [18].

Associations of TECT1 with chemical compounds

  • Clear tectonic penetrating graft using glycerine-preserved donor cornea [19].
  • The four largest Swedish lakes Vänern, Vättern, Mälaren and Hjälmaren all have a tectonic origin with multidirectional fault fissures, which influence the topography of the bottoms and the creation of subbasins [20].
  • The three (four) large tectonic units (Caledonian mountain chain, Fennoscandian Shield and the northern and southern eastern European Platform) composing this area are all reflected in the regional maps [21].
  • Radon, helium and uranium survey in some thermal springs located in NW Himalayas, India: mobilization by tectonic features or by geochemical barriers [22]?
  • Despite initial treatment with intravenous methylprednisolone and a conjunctival flap, a tectonic sectorial penetrating keratoplasty was required to preserve the globe and achieve a good visual result [23].

Other interactions of TECT1

  • PARTICIPANTS: Thirty-two patients with perforated (17) or deep (15) corneal ulcers (9 bacterial, 5 acanthamoebal, 10 herpetic, 3 associated with rheumatoid arthritis, 5 other) necessitating immediate tectonic keratoplasty [17].
  • Modern slab melts are thus unlike Archean Trondhjemite-Tonalite-Granodiorite rocks (TTG), which suggests that both types of magmas were generated via different petrogenetic pathways which may imply an Archean tectonic model of crust production different from that of the present-day, subduction-related, one [24].

Analytical, diagnostic and therapeutic context of TECT1


  1. Tectonic corneal lamellar grafting for severe scleral melting after pterygium surgery. Ti, S.E., Tan, D.T. Ophthalmology (2003) [Pubmed]
  2. Scleral flap necrosis and infectious endophthalmitis after cataract surgery with a scleral tunnel incision. Ormerod, L.D., Puklin, J.E., McHenry, J.G., McDermott, M.L. Ophthalmology (1993) [Pubmed]
  3. Penetrating keratoplasty in cicatrizing conjunctival diseases. Tugal-Tutkun, I., Akova, Y.A., Foster, C.S. Ophthalmology (1995) [Pubmed]
  4. Rhegmatogenous retinal detachment after block excision of epithelial implantation cysts and tumors of the anterior uvea. Jonas, J.B., Groh, M.J., Rummelt, V., Naumann, G.O. Ophthalmology (1999) [Pubmed]
  5. Tectonic keratoplasty for peripheral ulcerative keratitis. Raizman, M.B., Sainz de la Maza, M., Foster, C.S. Cornea (1991) [Pubmed]
  6. Resistance to mantle flow inferred from the electromagnetic strike of the Australian upper mantle. Simpson, F. Nature (2001) [Pubmed]
  7. 300-Myr-old magmatic CO2 in natural gas reservoirs of the west Texas Permian basin. Ballentine, C.J., Schoell, M., Coleman, D., Cain, B.A. Nature (2001) [Pubmed]
  8. Flooding of Ganymede's bright terrains by low-viscosity water-ice lavas. Schenk, P.M., McKinnon, W.B., Gwynn, D., Moore, J.M. Nature (2001) [Pubmed]
  9. Sea-floor hydrothermal activity links climate to tectonics: the Eocene carbon dioxide greenhouse. Owen, R.M., Rea, D.K. Science (1985) [Pubmed]
  10. Evaluating trans-tethys migration: an example using acrodont lizard phylogenetics. Macey, J.R., Schulte, J.A., Larson, A., Ananjeva, N.B., Wang, Y., Pethiyagoda, R., Rastegar-Pouyani, N., Papenfuss, T.J. Syst. Biol. (2000) [Pubmed]
  11. Molecular phylogeny of osteoglossoids: a new model for Gondwanian origin and plate tectonic transportation of the Asian arowana. Kumazawa, Y., Nishida, M. Mol. Biol. Evol. (2000) [Pubmed]
  12. Phylogeography and systematics of zebra mussels and related species. Gelembiuk, G.W., May, G.E., Lee, C.E. Mol. Ecol. (2006) [Pubmed]
  13. Molecular ecology of zebra mussel invasions. May, G.E., Gelembiuk, G.W., Panov, V.E., Orlova, M.I., Lee, C.E. Mol. Ecol. (2006) [Pubmed]
  14. DNA- versus RNA-based methods for human papillomavirus detection in cervical neoplasia. Lie, A.K., Risberg, B., Borge, B., Sandstad, B., Delabie, J., Rimala, R., Onsrud, M., Thoresen, S. Gynecol. Oncol. (2005) [Pubmed]
  15. Long-term follow-up results of lamellar keratoplasty as a treatment for recurrent pterygium and for scleral necrosis induced by beta-irradiation. Golchin, B., Butler, T.K., Robinson, L.P., Wechsler, A.W., Sutton, G., Robinson, D.I., McClellan, K. Cornea (2003) [Pubmed]
  16. Block excision of tumors of the anterior uvea. Report on 68 consecutive patients. Naumann, G.O., Rummelt, V. Ophthalmology (1996) [Pubmed]
  17. Nonmechanical excimer laser penetrating keratoplasty for perforated or predescemetal corneal ulcers. Küchle, M., Seitz, B., Langenbucher, A., Naumann, G.O. Ophthalmology (1999) [Pubmed]
  18. "Tectonic" hippocampal malformations in patients with temporal lobe epilepsy. Sloviter, R.S., Kudrimoti, H.S., Laxer, K.D., Barbaro, N.M., Chan, S., Hirsch, L.J., Goodman, R.R., Pedley, T.A. Epilepsy Res. (2004) [Pubmed]
  19. Clear tectonic penetrating graft using glycerine-preserved donor cornea. Sharma, A., Gupta, P., Narang, S., Ram, J., Gupta, A. Eye (London, England) (2001) [Pubmed]
  20. Morphometry and hydrology of the four large lakes of Sweden. Kvarnäs, H. Ambio. (2001) [Pubmed]
  21. Baltic soil survey: total concentrations of major and selected trace elements in arable soils from 10 countries around the Baltic Sea. Reimann, C., Siewers, U., Tarvainen, T., Bityukova, L., Eriksson, J., Gilucis, A., Gregorauskiene, V., Lukashev, V., Matinian, N.N., Pasieczna, A. Sci. Total Environ. (2000) [Pubmed]
  22. Radon, helium and uranium survey in some thermal springs located in NW Himalayas, India: mobilization by tectonic features or by geochemical barriers? Walia, V., Quattrocchi, F., Virk, H.S., Yang, T.F., Pizzino, L., Bajwa, B.S. Journal of environmental monitoring : JEM. (2005) [Pubmed]
  23. Corneal perforation due to severe peripheral ulcerative keratitis in Crohn disease. Tan, M.H., Chen, S.D., Rubinstein, A., Bron, A.J. Cornea (2006) [Pubmed]
  24. Oceanic slab melting and mantle metasomatism. Scaillet, B., Prouteau, G. Science progress. (2001) [Pubmed]
  25. Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy. Kervick, G.N., Pflugfelder, S.C., Haimovici, R., Brown, H., Tozman, E., Yee, R. Ophthalmology (1992) [Pubmed]
  26. Long-term follow-up of patients with atopic keratoconjunctivitis. Power, W.J., Tugal-Tutkun, I., Foster, C.S. Ophthalmology (1998) [Pubmed]
  27. Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris. Cursiefen, C., Schlötzer-Schrehardt, U., Holbach, L.M., Naumann, G.O. Arch. Ophthalmol. (1999) [Pubmed]
  28. Tarsoconjunctival pedicle flap for the management of a severe scleral melt. Davidson, R.S., Erlanger, M., Taravella, M., Gregory, D.G., Durairaj, V.D. Cornea (2007) [Pubmed]
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