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Gene Review

ZDHHC3  -  zinc finger, DHHC-type containing 3

Homo sapiens

Synonyms: DHHC-3, GODZ, HSD49, Palmitoyltransferase ZDHHC3, Protein DHHC1, ...
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High impact information on ZDHHC3

  • Collectively, our data describe five new Golgi-targeted DHHC enzymes in human endothelial cells and suggest a regulatory role of DHHC-21 in governing eNOS localization and function [1].
  • Transfection of human embryonic kidney 293 cells with the complementary DNA (cDNA) for eNOS and 23 cDNA clones encoding the Asp-His-His-Cys motif (DHHC) palmitoyl transferase family members showed that five clones (2, 3, 7, 8, and 21) enhanced incorporation of [3H]-palmitate into eNOS [1].
  • TIP1 encodes an ankyrin repeat protein with a DHHC Cys-rich domain that is expressed in roots, leaves, inflorescence stems, and floral tissue [2].
  • DHHC9 is an integral membrane protein that contains a DHHC cysteine-rich domain [3].
  • Numerous genes encoding DHHC domain proteins are found in all eukaryotic genome databases [4].

Biological context of ZDHHC3


Anatomical context of ZDHHC3

  • Most DHHC proteins are localized in the ER and/or Golgi, with a few localized in the plasma membrane and one in the yeast vacuole [6].


  1. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. Fernández-Hernando, C., Fukata, M., Bernatchez, P.N., Fukata, Y., Lin, M.I., Bredt, D.S., Sessa, W.C. J. Cell Biol. (2006) [Pubmed]
  2. The TIP GROWTH DEFECTIVE1 S-acyl transferase regulates plant cell growth in Arabidopsis. Hemsley, P.A., Kemp, A.C., Grierson, C.S. Plant Cell (2005) [Pubmed]
  3. DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. Swarthout, J.T., Lobo, S., Farh, L., Croke, M.R., Greentree, W.K., Deschenes, R.J., Linder, M.E. J. Biol. Chem. (2005) [Pubmed]
  4. Protein palmitoylation by a family of DHHC protein S-acyltransferases. Mitchell, D.A., Vasudevan, A., Linder, M.E., Deschenes, R.J. J. Lipid Res. (2006) [Pubmed]
  5. Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Uemura, T., Mori, H., Mishina, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  6. Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Ohno, Y., Kihara, A., Sano, T., Igarashi, Y. Biochim. Biophys. Acta (2006) [Pubmed]
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