Disease relevance of HMP19

• In avian sarcoma and leukemia viruses, the gag protein p19 functions structurally as a matrix protein, connecting internal components with the viral envelope [1].
• Digestion of oxidized MC29 110K and AEV 75K proteins with the Staphylococcus aureus V8 protease generated a fragment which comigrated with N-acetylmethionylsulfoneglutamic acid, a blocked dipeptide which is the putative amino-terminal sequence of structural protein p19 and gag precursor Pr76gag [2].
• Electron microscopy of astroglial cells exposed to HTLV-I revealed the presence of vacuoli-like structures containing viral core protein p19 [3].

High impact information on HMP19

• Fine-structure analyses of lipid-protein and protein-protein interactions of gag protein p19 of the avian sarcoma and leukemia viruses by cyanogen bromide mapping [1].
• Similarities between the synthesized Pro-rich protein Y and three proline-rich proteins, the human salivary Pro-rich protein, the avian sarcoma virus protein P19 and the myc oncogene product, were evident and the significance of these findings is discussed [4].
• Moreover IFN beta treatment caused 60%-80% inhibition of virus expression in CBCD4, assayed as the presence of virus core protein p19 [5].
• This cell line bore HTLV-I sequences as demonstrated by PCR analysis, and 60-90% of the DP cells expressed the virus core protein p19 [6].
• Fifty-six per cent of GFAP positive astrocytes showed the viral core protein p19 and increased expression of Class II MHC antigens [3].

Anatomical context of HMP19

• The presence of HTLV-I in the cultured T-cell line was established by the detection of expressed viral specific gag protein p-19 and proviral DNA [7].

Other interactions of HMP19

• Actually after 7 days, cells exposed to HTLV-I showed the virus core protein p19 together with an high expression of class II antigens and a disorganization of the GFAP [8].

Analytical, diagnostic and therapeutic context of HMP19

• These results were confirmed by PCR and by flow cytometry analysis for the viral core protein p19 [9].
• Epitope mapping of monoclonal antibodies to gag protein p19 of avian sarcoma and leukaemia viruses [10].
• Virus expression has been monitored through an indirect immunofluorescence assay using a monoclonal antibody against virus core protein p19 [11].

References