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Gene Review

UIMC1  -  ubiquitin interaction motif containing 1

Homo sapiens

Synonyms: BRCA1-A complex subunit RAP80, RAP80, RXRIP110, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, ...
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Disease relevance of UIMC1


High impact information on UIMC1


Biological context of UIMC1


Anatomical context of UIMC1

  • RAP80 mRNA is expressed in many human tissues, but its expression is particularly high in testis [2].

Associations of UIMC1 with chemical compounds

  • RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor [2].

Analytical, diagnostic and therapeutic context of UIMC1


  1. The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. Yan, J., Kim, Y.S., Yang, X.P., Li, L.P., Liao, G., Xia, F., Jetten, A.M. Cancer Res. (2007) [Pubmed]
  2. RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor. Yan, Z., Kim, Y.S., Jetten, A.M. J. Biol. Chem. (2002) [Pubmed]
  3. Tsp57: a novel gene induced during a specific stage of spermatogenesis. Kim, Y.S., Nakanishi, G., Oudes, A.J., Kim, K.H., Wang, H., Kilpatrick, D.L., Jetten, A.M. Biol. Reprod. (2004) [Pubmed]
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