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ZFYVE1  -  zinc finger, FYVE domain containing 1

Homo sapiens

Synonyms: DFCP1, Double FYVE-containing protein 1, KIAA1589, PP10436, PPP1R172, ...
 
 
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High impact information on ZFYVE1

  • By contrast, exogenously expressed DFCP1 displays a predominantly Golgi, endoplasmic reticulum (ER) and vesicular distribution with little or no overlap with FENS-1 or other endosomal markers [1].
  • Overexpression of DFCP1 was found to cause dispersal of the Golgi compartment defined by giantin and gpp130-staining [1].
  • The protein is expressed predominantly in heart and binds to PtdIns3P specifically, even though the FYVE domains in TAFF1 lacks the first Arg of the consensus sequence R(K/R)HHCR, critical for the PtdIns3P binding of other FYVE domains identified so far [2].
  • The gene, ZNFN2A1 (GenBank accession no. AF251025) was localized to chromosome 14q22-q24 and shown to be composed of 11 exons [3].
  • Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library [3].
 

Biological context of ZFYVE1

  • Following in vitro transfection of a DFCP1-containing expression construct, confocal microscopy studies showed a vesicular distribution of DFCP1 suggesting that this protein, like other FYVE-containing proteins, might be involved in membrane trafficking [3].
  • Nucleotide sequence analysis showed that clone SR2 has 94.8% homology to the salT gene, and clones SI1 and SR3 show 88.3 and 96.9% identity, respectively, to partial cDNA sequences in the GenBank database [4].
  • Somatic cell hybrids between HeLa SR3 and HeLa A5F exhibited intermediate levels of GPH alpha gene expression and colony formation in soft agar compared to the parental strains [5].
  • The main objective of this study was to explore the mechanical and electrical output of thigh muscles derived from a range of motion (RoM) of 90 degrees (0-90 degrees flexion, LR) and the three successive RoMs: 0-30 degrees (SR1), 30-60 degrees (SR2) and 60-90 degrees (SR3) [6].
  • CONCLUSION: Numerous copies of SR3, a novel non-LTR retrotransposon of the RTE clade are present in the genome of S. mansoni [7].
 

Anatomical context of ZFYVE1

  • The DNA-protein complexes generated between a trophoblast specific element (TSE) and nuclear proteins in HeLa SR3 and JELA migrated significantly more slowly than the complex generated by JEG-3 nuclear proteins [8].
 

Associations of ZFYVE1 with chemical compounds

  • Clones SI1 and SI2 were repressed by sucrose starvation, while clones SR1, SR2, SR3 and SR4 were induced by sucrose starvation [4].
  • The hybrid cells, pooled clones resistant to both hygromycin B and G418 sulfate, have been named JELA and were indistinguishable from the SR3 parent with regard to induction of the GPHalpha gene [8].

References

  1. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. Ridley, S.H., Ktistakis, N., Davidson, K., Anderson, K.E., Manifava, M., Ellson, C.D., Lipp, P., Bootman, M., Coadwell, J., Nazarian, A., Erdjument-Bromage, H., Tempst, P., Cooper, M.A., Thuring, J.W., Lim, Z.Y., Holmes, A.B., Stephens, L.R., Hawkins, P.T. J. Cell. Sci. (2001) [Pubmed]
  2. Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi. Cheung, P.C., Trinkle-Mulcahy, L., Cohen, P., Lucocq, J.M. Biochem. J. (2001) [Pubmed]
  3. Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library. Derubeis, A.R., Young, M.F., Jia, L., Robey, P.G., Fisher, L.W. Gene (2000) [Pubmed]
  4. Identification of sucrose-regulated genes in cultured rice cells using mRNA differential display. Tseng, T.C., Tsai, T.H., Lue, M.Y., Lee, H.T. Gene (1995) [Pubmed]
  5. Correlation in HeLa cells of anchorage-independent growth and synthesis of the glycoprotein hormone alpha-subunit. Cox, G.S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Testing knee extension and flexion strength at different ranges of motion: an isokinetic and electromyographic study. Reichard, L.B., Croisier, J.L., Malnati, M., Katz-Leurer, M., Dvir, Z. Eur. J. Appl. Physiol. (2005) [Pubmed]
  7. Characterization of SR3 reveals abundance of non-LTR retrotransposons of the RTE clade in the genome of the human blood fluke, Schistosoma mansoni. Laha, T., Kewgrai, N., Loukas, A., Brindley, P.J. BMC Genomics (2005) [Pubmed]
  8. Cellular responses to sodium butyrate exhibit the dominance of one parental phenotype in somatic cell hybrids. Cox, G.S. Mol. Cell Biol. Res. Commun. (2000) [Pubmed]
 
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