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Gene Review

WDFY1  -  WD repeat and FYVE domain containing 1

Homo sapiens

Synonyms: FENS-1, KIAA1435, Phosphoinositide-binding protein 1, WD repeat and FYVE domain-containing protein 1, WD40-and FYVE domain-containing protein 1, ...
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Disease relevance of WDFY1


High impact information on WDFY1


Biological context of WDFY1

  • Low-sulfate, acidic (approximately pH 4) fens in the Lehstenbach catchment in the Fichtelgebirge mountains in Germany are unusual habitats for sulfate-reducing prokaryotes (SRPs) that have been postulated to facilitate the retention of sulfur and protons in these ecosystems [7].
  • Cautious extrapolation of our data to the ecosystem level suggests that decomposition rates in fens may increase and those in bogs may decrease under a global warming scenario [8].

Anatomical context of WDFY1


Associations of WDFY1 with chemical compounds

  • Microarray and functional gene analyses of sulfate-reducing prokaryotes in low-sulfate, acidic fens reveal cooccurrence of recognized genera and novel lineages [7].
  • The two fens had very similar diversity of methanogenic methyl-coenzyme M reductase gene (mcrA), but in the upper layer of the bog the methanogen diversity was strikingly lower, and only one type of mcrA sequence was retrieved [10].
  • This study provides new data on the ecology of testate amoebae in fens, and the transfer function models should allow quantitative palaeohydrological reconstruction [11].
  • C4 grasses in boreal fens: their occurrence in relation to microsite characteristics [12].
  • Methylmercury concentrations in the wetlands were highly dependent (P < 0.08) on lithology with no significant difference between bogs, fens, and swamps [13].

Analytical, diagnostic and therapeutic context of WDFY1

  • These results were confirmed and extended by comparative analyses of environmentally retrieved 16S rRNA and dissimilatory (bi)sulfite reductase (dsrAB) gene sequences; dsrAB sequences from Desulfobacca-like SRPs, which were not identified by microarray analysis, were obtained from both fens [7].
  • 16S rRNA gene-based oligonucleotide microarray analyses revealed stable diversity patterns for recognized SRPs in the upper 30 cm of both fens [7].


  1. EST-based genome-wide gene inactivation identifies ARAP3 as a host protein affecting cellular susceptibility to anthrax toxin. Lu, Q., Wei, W., Kowalski, P.E., Chang, A.C., Cohen, S.N. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Syphilis in the fens. Palfreeman, A.J., Moussa, R.A. Sexually transmitted infections. (2001) [Pubmed]
  3. PENS, the new joint Programme for European Neuroscience Schools: FENS and IBRO turn past into future. Aguayo, A.J., Freund, T., Huck, S. Trends Neurosci. (2005) [Pubmed]
  4. The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis. Suh, C.I., Stull, N.D., Li, X.J., Tian, W., Price, M.O., Grinstein, S., Yaffe, M.B., Atkinson, S., Dinauer, M.C. J. Exp. Med. (2006) [Pubmed]
  5. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. Ridley, S.H., Ktistakis, N., Davidson, K., Anderson, K.E., Manifava, M., Ellson, C.D., Lipp, P., Bootman, M., Coadwell, J., Nazarian, A., Erdjument-Bromage, H., Tempst, P., Cooper, M.A., Thuring, J.W., Lim, Z.Y., Holmes, A.B., Stephens, L.R., Hawkins, P.T. J. Cell. Sci. (2001) [Pubmed]
  6. Full-contact domain labeling: identification of a novel phosphoinositide binding site on gelsolin that requires the complete protein. Feng, L., Mejillano, M., Yin, H.L., Chen, J., Prestwich, G.D. Biochemistry (2001) [Pubmed]
  7. Microarray and functional gene analyses of sulfate-reducing prokaryotes in low-sulfate, acidic fens reveal cooccurrence of recognized genera and novel lineages. Loy, A., Küsel, K., Lehner, A., Drake, H.L., Wagner, M. Appl. Environ. Microbiol. (2004) [Pubmed]
  8. Microcosm tests of the effects of temperature and microbial species number on the decomposition of Carex aquatilis and Sphagnum fuscum litter from southern boreal peatlands. Thormann, M.N., Bayley, S.E., Currah, R.S. Can. J. Microbiol. (2004) [Pubmed]
  9. Controlling cytoskeleton structure by phosphoinositide-protein interactions: phosphoinositide binding protein domains and effects of lipid packing. Janmey, P.A., Xian, W., Flanagan, L.A. Chem. Phys. Lipids (1999) [Pubmed]
  10. Methanogen communities and Bacteria along an ecohydrological gradient in a northern raised bog complex. Juottonen, H., Galand, P.E., Tuittila, E.S., Laine, J., Fritze, H., Yrjälä, K. Environ. Microbiol. (2005) [Pubmed]
  11. Ecology of testate amoebae from mires in the central rhodope mountains, Greece and development of a transfer function for palaeohydrological reconstruction. Payne, R.J., Mitchell, E.A. Protist (2007) [Pubmed]
  12. C4 grasses in boreal fens: their occurrence in relation to microsite characteristics. Kubien, D.S., Sage, R.F. Oecologia (2003) [Pubmed]
  13. Are methylmercury concentrations in the wetlands of Kejimkujik National Park, Nova Scotia, Canada, dependent on geology? Siciliano, S.D., Sangster, A., Daughney, C.J., Loseto, L., Germida, J.J., Rencz, A.N., O'Driscoll, N.J., Lean, D.R. J. Environ. Qual. (2003) [Pubmed]
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