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Gene Review

Gclc  -  Glutamate-cysteine ligase catalytic subunit

Drosophila melanogaster

Synonyms: 2259, CG2259, DmGCLC, DmGCS, DmGCSh, ...
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Disease relevance of Gclc


High impact information on Gclc


Biological context of Gclc


Associations of Gclc with chemical compounds


Physical interactions of Gclc

  • DmGCLC co-immunoprecipitated with DmGCLM from S2 cell extracts, suggesting that they also associate in vivo [1].


  1. Drosophila melanogaster glutamate-cysteine ligase activity is regulated by a modifier subunit with a mechanism of action similar to that of the mammalian form. Fraser, J.A., Saunders, R.D., McLellan, L.I. J. Biol. Chem. (2002) [Pubmed]
  2. Overexpression of glutamate-cysteine ligase extends life span in Drosophila melanogaster. Orr, W.C., Radyuk, S.N., Prabhudesai, L., Toroser, D., Benes, J.J., Luchak, J.M., Mockett, R.J., Rebrin, I., Hubbard, J.G., Sohal, R.S. J. Biol. Chem. (2005) [Pubmed]
  3. The modifier subunit of Drosophila glutamate-cysteine ligase regulates catalytic activity by covalent and noncovalent interactions and influences glutathione homeostasis in vivo. Fraser, J.A., Kansagra, P., Kotecki, C., Saunders, R.D., McLellan, L.I. J. Biol. Chem. (2003) [Pubmed]
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