The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Gclc  -  glutamate-cysteine ligase, catalytic subunit

Rattus norvegicus

Synonyms: GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, Glclc, Glutamate--cysteine ligase catalytic subunit
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Gclc


Psychiatry related information on Gclc


High impact information on Gclc


Chemical compound and disease context of Gclc


Biological context of Gclc


Anatomical context of Gclc


Associations of Gclc with chemical compounds


Other interactions of Gclc


Analytical, diagnostic and therapeutic context of Gclc


  1. Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma. Biocca, M.E., Canuto, R.A., Muzio, G., Rossi, M.A., Dianzani, M.U. Toxicologic pathology. (1986) [Pubmed]
  2. Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia. Beutler, E., Moroose, R., Kramer, L., Gelbart, T., Forman, L. Blood (1990) [Pubmed]
  3. Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. Liu, R.M., Hu, H., Robison, T.W., Forman, H.J. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  4. Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Wang, C.J., Wang, S.W., Lin, J.K. Cancer Lett. (1991) [Pubmed]
  5. Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. Lu, S.C., Ge, J.L., Kuhlenkamp, J., Kaplowitz, N. J. Clin. Invest. (1992) [Pubmed]
  6. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L., Forman, H.J. J. Biol. Chem. (1994) [Pubmed]
  7. Modulation of cell injury and survival by high glucose and advancing age. Fukagawa, N.K., Li, M., Timblin, C.R., Mossman, B.T. Free Radic. Biol. Med. (2001) [Pubmed]
  8. Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Fernandes, C.J., Rong, L., Tamura, T., Stewart, K.D., Rogers, L.K., McMicken, H.W., Elliston, J.F., Hansen, T.N., Smith, C.V. Toxicol. Lett. (2002) [Pubmed]
  9. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Luderer, U., Diaz, D., Faustman, E.M., Kavanagh, T.J. Mol. Reprod. Dev. (2003) [Pubmed]
  10. Up-regulation of K(+) channels in diabetic rat ventricular myocytes by insulin and glutathione. Xu, Z., Patel, K.P., Lou, M.F., Rozanski, G.J. Cardiovasc. Res. (2002) [Pubmed]
  11. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Tsuchiya, K., Mulcahy, R.T., Reid, L.L., Disteche, C.M., Kavanagh, T.J. Genomics (1995) [Pubmed]
  12. A possible mechanism of heinz body hemolytic anemia induced by DQ-2511, a new gastroprokinetic drug, in dogs. Ohno, H., Nomura, M., Watanabe, K. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  13. Lead stimulates the glutathione system in selective regions of rat brain. Struzyńska, L., Sułkowski, G., Lenkiewicz, A., Rafałowska, U. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (2002) [Pubmed]
  14. Protection of cultured gastric cells against tert-butyl hydroperoxide by glutathione isopropyl ester. Yamaguchi, N., Yajima, N., Ishida, M., Shimada, T., Hiraishi, H. Eur. J. Pharmacol. (1998) [Pubmed]
  15. Maternal ethanol consumption during pregnancy enhances bile acid-induced oxidative stress and apoptosis in fetal rat liver. Perez, M.J., Velasco, E., Monte, M.J., Gonzalez-Buitrago, J.M., Marin, J.J. Toxicology (2006) [Pubmed]
  16. Glutathione synthesis and glutathione redox pathways in naphthalene cataract of the rat. Rathbun, W.B., Holleschau, A.M., Murray, D.L., Buchanan, A., Sawaguchi, S., Tao, R.V. Curr. Eye Res. (1990) [Pubmed]
  17. Peroxisome proliferator perfluorodecanoic acid alters glutathione and related enzymes. Chen, L.C., Tatum, V., Glauert, H.P., Chow, C.K. J. Biochem. Mol. Toxicol. (2001) [Pubmed]
  18. Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes. Lu, S.C., Ge, J.L. Am. J. Physiol. (1992) [Pubmed]
  19. Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate. Sekhar, K.R., Long, M., Long, J., Xu, Z.Q., Summar, M.L., Freeman, M.L. Radiat. Res. (1997) [Pubmed]
  20. Gonadotropin regulation of glutathione synthesis in the rat ovary. Luderer, U., Kavanagh, T.J., White, C.C., Faustman, E.M. Reprod. Toxicol. (2001) [Pubmed]
  21. Regulation of glutathione in cardiac myocytes. Li, S., Li, X., Rozanski, G.J. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  22. Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat. Yan, C.C., Huxtable, R.J. Biochem. Pharmacol. (1996) [Pubmed]
  23. Influence of selenium on glutathione and some associated enzymes in rats with mammary tumor induced by 7,12-dimethylbenz(a)anthracene. Chidambaram, N., Baradarajan, A. Mol. Cell. Biochem. (1996) [Pubmed]
  24. Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis. Hirata, T., Koehler, R.C., Kawaguchi, T., Brusilow, S.W., Traystman, R.J. Stroke (1996) [Pubmed]
  25. Determination of L-buthionin (SR)-sulfoximine, gamma-glutamylcysteine synthetase inhibitor in rat plasma with HPLC after prelabeling with dansyl chloride. Koyama, H., Sugioka, N., Hirata, I., Ohta, T., Kishimoto, H. Journal of chromatographic science. (1996) [Pubmed]
WikiGenes - Universities