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Gclc  -  glutamate-cysteine ligase, catalytic subunit

Rattus norvegicus

Synonyms: GCS heavy chain, Gamma-ECS, Gamma-glutamylcysteine synthetase, Glclc, Glutamate--cysteine ligase catalytic subunit
 
 
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Biological context of Gclc

 

Anatomical context of Gclc

 

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Analytical, diagnostic and therapeutic context of Gclc

References

  1. Glutathione synthesis in normal liver and in Yoshida AH-130 hepatoma. Biocca, M.E., Canuto, R.A., Muzio, G., Rossi, M.A., Dianzani, M.U. Toxicologic pathology. (1986) [Pubmed]
  2. Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia. Beutler, E., Moroose, R., Kramer, L., Gelbart, T., Forman, L. Blood (1990) [Pubmed]
  3. Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. Liu, R.M., Hu, H., Robison, T.W., Forman, H.J. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  4. Suppressive effect of geniposide on the hepatotoxicity and hepatic DNA binding of aflatoxin B1 in rats. Wang, C.J., Wang, S.W., Lin, J.K. Cancer Lett. (1991) [Pubmed]
  5. Insulin and glucocorticoid dependence of hepatic gamma-glutamylcysteine synthetase and glutathione synthesis in the rat. Studies in cultured hepatocytes and in vivo. Lu, S.C., Ge, J.L., Kuhlenkamp, J., Kaplowitz, N. J. Clin. Invest. (1992) [Pubmed]
  6. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L., Forman, H.J. J. Biol. Chem. (1994) [Pubmed]
  7. Modulation of cell injury and survival by high glucose and advancing age. Fukagawa, N.K., Li, M., Timblin, C.R., Mossman, B.T. Free Radic. Biol. Med. (2001) [Pubmed]
  8. Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Fernandes, C.J., Rong, L., Tamura, T., Stewart, K.D., Rogers, L.K., McMicken, H.W., Elliston, J.F., Hansen, T.N., Smith, C.V. Toxicol. Lett. (2002) [Pubmed]
  9. Localization of glutamate cysteine ligase subunit mRNA within the rat ovary and relationship to follicular apoptosis. Luderer, U., Diaz, D., Faustman, E.M., Kavanagh, T.J. Mol. Reprod. Dev. (2003) [Pubmed]
  10. Up-regulation of K(+) channels in diabetic rat ventricular myocytes by insulin and glutathione. Xu, Z., Patel, K.P., Lou, M.F., Rozanski, G.J. Cardiovasc. Res. (2002) [Pubmed]
  11. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3. Tsuchiya, K., Mulcahy, R.T., Reid, L.L., Disteche, C.M., Kavanagh, T.J. Genomics (1995) [Pubmed]
  12. A possible mechanism of heinz body hemolytic anemia induced by DQ-2511, a new gastroprokinetic drug, in dogs. Ohno, H., Nomura, M., Watanabe, K. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  13. Lead stimulates the glutathione system in selective regions of rat brain. Struzyńska, L., Sułkowski, G., Lenkiewicz, A., Rafałowska, U. Folia neuropathologica / Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences. (2002) [Pubmed]
  14. Protection of cultured gastric cells against tert-butyl hydroperoxide by glutathione isopropyl ester. Yamaguchi, N., Yajima, N., Ishida, M., Shimada, T., Hiraishi, H. Eur. J. Pharmacol. (1998) [Pubmed]
  15. Maternal ethanol consumption during pregnancy enhances bile acid-induced oxidative stress and apoptosis in fetal rat liver. Perez, M.J., Velasco, E., Monte, M.J., Gonzalez-Buitrago, J.M., Marin, J.J. Toxicology (2006) [Pubmed]
  16. Glutathione synthesis and glutathione redox pathways in naphthalene cataract of the rat. Rathbun, W.B., Holleschau, A.M., Murray, D.L., Buchanan, A., Sawaguchi, S., Tao, R.V. Curr. Eye Res. (1990) [Pubmed]
  17. Peroxisome proliferator perfluorodecanoic acid alters glutathione and related enzymes. Chen, L.C., Tatum, V., Glauert, H.P., Chow, C.K. J. Biochem. Mol. Toxicol. (2001) [Pubmed]
  18. Loss of suppression of GSH synthesis at low cell density in primary cultures of rat hepatocytes. Lu, S.C., Ge, J.L. Am. J. Physiol. (1992) [Pubmed]
  19. Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate. Sekhar, K.R., Long, M., Long, J., Xu, Z.Q., Summar, M.L., Freeman, M.L. Radiat. Res. (1997) [Pubmed]
  20. Gonadotropin regulation of glutathione synthesis in the rat ovary. Luderer, U., Kavanagh, T.J., White, C.C., Faustman, E.M. Reprod. Toxicol. (2001) [Pubmed]
  21. Regulation of glutathione in cardiac myocytes. Li, S., Li, X., Rozanski, G.J. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  22. Effects of monocrotaline, a pyrrolizidine alkaloid, on glutathione metabolism in the rat. Yan, C.C., Huxtable, R.J. Biochem. Pharmacol. (1996) [Pubmed]
  23. Influence of selenium on glutathione and some associated enzymes in rats with mammary tumor induced by 7,12-dimethylbenz(a)anthracene. Chidambaram, N., Baradarajan, A. Mol. Cell. Biochem. (1996) [Pubmed]
  24. Impaired pial arteriolar reactivity to hypercapnia during hyperammonemia depends on glutamine synthesis. Hirata, T., Koehler, R.C., Kawaguchi, T., Brusilow, S.W., Traystman, R.J. Stroke (1996) [Pubmed]
  25. Determination of L-buthionin (SR)-sulfoximine, gamma-glutamylcysteine synthetase inhibitor in rat plasma with HPLC after prelabeling with dansyl chloride. Koyama, H., Sugioka, N., Hirata, I., Ohta, T., Kishimoto, H. Journal of chromatographic science. (1996) [Pubmed]
 
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