High impact information on Ngef

• The association of ephexin with Eph receptors constitutes a molecular link between Eph receptors and the actin cytoskeleton and provides a novel mechanism for achieving highly localized regulation of growth cone motility [1].
• In addition, expression of a mutant form of ephexin in primary neurons interferes with ephrin-A-induced growth cone collapse [1].
• EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin [1].
• Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement [2].
• We have localized the Ngef gene to mouse chromosome 1 and the human homologue of Ngef to human chromosome 2q37 [2].

Biological context of Ngef

• Ngef contains a translated trinucleotide repeat, a polyglutamic acid stretch interrupted by a glycine [2].

Analytical, diagnostic and therapeutic context of Ngef

• We have shown in preliminary experiments that Ngef has transforming potential in cell culture and is able to induce tumors in nude mice [2].

References