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Gene Review

Lpar2  -  lysophosphatidic acid receptor 2

Mus musculus

Synonyms: Edg4, IPA2, LPA receptor 2, LPA-2, LPA2, ...
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High impact information on Edg4

  • LPA inhibited CFTR-dependent iodide efflux through LPA2-mediated Gi pathway, and LPA inhibited CFTR-mediated short-circuit currents in a compartmentalized fashion [1].
  • Previously we have shown that TRIP6 binds to the LPA2 receptor and associates with several components of focal complexes in an agonist-dependent manner and, thus, enhances lysophosphatidic acid (LPA)-induced cell migration [2].
  • Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2) [3].
  • The separate effects of each LPA R were studied in Jurkat T cell transfectants expressing principally human Edg-2 Rs (Jurkat-T-2) or Edg-4 Rs (Jurkat-T-4) and stimulated with anti-CD3 plus phorbol myristate acetate [4].
  • By real-time PCR, LPA1-3 receptor mRNAs were expressed in mouse renal cortex, outer medulla, and inner medulla with the following rank order LPA3 = LPA2 > LPA1 [5].

Biological context of Edg4

  • One such variant (a G deletion) in the initially characterized Edg4 cDNA clone (derived from an ovarian tumor) results in a frameshift mutation near the 3' end of the coding region [6].

Anatomical context of Edg4

  • After mitogen activation, the CD4+ T cells express Ed g-2 Rs at approximately one half the level of Edg-4 Rs [4].

Analytical, diagnostic and therapeutic context of Edg4


  1. Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions. Li, C., Dandridge, K.S., Di, A., Marrs, K.L., Harris, E.L., Roy, K., Jackson, J.S., Makarova, N.V., Fujiwara, Y., Farrar, P.L., Nelson, D.J., Tigyi, G.J., Naren, A.P. J. Exp. Med. (2005) [Pubmed]
  2. c-Src-mediated phosphorylation of TRIP6 regulates its function in lysophosphatidic acid-induced cell migration. Lai, Y.J., Chen, C.S., Lin, W.C., Lin, F.T. Mol. Cell. Biol. (2005) [Pubmed]
  3. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Contos, J.J., Ishii, I., Fukushima, N., Kingsbury, M.A., Ye, X., Kawamura, S., Brown, J.H., Chun, J. Mol. Cell. Biol. (2002) [Pubmed]
  4. Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. Zheng, Y., Voice, J.K., Kong, Y., Goetzl, E.J. FASEB J. (2000) [Pubmed]
  5. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Okusa, M.D., Ye, H., Huang, L., Sigismund, L., Macdonald, T., Lynch, K.R. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  6. Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA. Contos, J.J., Chun, J. Genomics (2000) [Pubmed]
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