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Gene Review

Lpar3  -  lysophosphatidic acid receptor 3

Mus musculus

Synonyms: Edg7, LPA receptor 3, LPA-3, LPA3, Lpa3, ...
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Disease relevance of Edg7


High impact information on Edg7

  • In contrast, a dual LPA1/LPA3-receptor antagonist, VPC-12249, reduced I/R injury, but this protective effect was lost when the antagonist was coadministered with OMPT [1].
  • By real-time PCR, LPA1-3 receptor mRNAs were expressed in mouse renal cortex, outer medulla, and inner medulla with the following rank order LPA3 = LPA2 > LPA1 [1].
  • The LPA-induced plasma exudation was inhibited by ketotifen, a histamine H1-receptor antagonist, and diacylglycerol pyrophosphate (DGPP), a LPA1/LPA3-receptor antagonist [3].
  • These findings indicate that plasma exudation induced by LPA is mediated by histamine release from mast cells via LPA receptor(s), presumably LPA1 and/or LPA3, coupled to G(i/o) proteins [3].
  • Exogenous administration of PGE2 or carbaprostacyclin (a stable analogue of PGI2) into LPA3-deficient female mice rescued delayed implantation but did not rescue defects in embryo spacing [4].

Biological context of Edg7


Anatomical context of Edg7

  • An enzyme demonstrated to influence implantation, cyclooxygenase 2 (COX2) (ref. 5), was downregulated in LPA3-deficient uteri during pre-implantation [4].

Associations of Edg7 with chemical compounds

  • Here we report a newly discovered molecular influence on implantation through the lysophosphatidic acid (LPA) receptor LPA3 (refs 2-4) [4].
  • These data identify LPA3 receptor-mediated signalling as having an influence on implantation, and further indicate linkage between LPA signalling and prostaglandin biosynthesis [4].


  1. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Okusa, M.D., Ye, H., Huang, L., Sigismund, L., Macdonald, T., Lynch, K.R. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  2. Lysophosphatidic acid induces chemotaxis in MC3T3-E1 osteoblastic cells. Masiello, L.M., Fotos, J.S., Galileo, D.S., Karin, N.J. Bone (2006) [Pubmed]
  3. Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors. Hashimoto, T., Ohata, H., Honda, K. J. Pharmacol. Sci. (2006) [Pubmed]
  4. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Ye, X., Hama, K., Contos, J.J., Anliker, B., Inoue, A., Skinner, M.K., Suzuki, H., Amano, T., Kennedy, G., Arai, H., Aoki, J., Chun, J. Nature (2005) [Pubmed]
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