Gene Review:
Lpar1 - lysophosphatidic acid receptor 1
Mus musculus
Synonyms:
AI326300, Edg2, Gpcr26, Kdt2, LPA receptor 1, ...
- Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis. Deng, W., Balazs, L., Wang, D.A., Van Middlesworth, L., Tigyi, G., Johnson, L.R. Gastroenterology (2002)
- Lysophosphatidic acid (LPA) in malignant ascites stimulates motility of human pancreatic cancer cells through LPA1. Yamada, T., Sato, K., Komachi, M., Malchinkhuu, E., Tobo, M., Kimura, T., Kuwabara, A., Yanagita, Y., Ikeya, T., Tanahashi, Y., Ogawa, T., Ohwada, S., Morishita, Y., Ohta, H., Im, D.S., Tamoto, K., Tomura, H., Okajima, F. J. Biol. Chem. (2004)
- The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases. Boucharaba, A., Serre, C.M., Guglielmi, J., Bordet, J.C., Clézardin, P., Peyruchaud, O. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Furui, T., LaPushin, R., Mao, M., Khan, H., Watt, S.R., Watt, M.A., Lu, Y., Fang, X., Tsutsui, S., Siddik, Z.H., Bast, R.C., Mills, G.B. Clin. Cancer Res. (1999)
- Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. Hecht, J.H., Weiner, J.A., Post, S.R., Chun, J. J. Cell Biol. (1996)
- Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Contos, J.J., Fukushima, N., Weiner, J.A., Kaushal, D., Chun, J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Contos, J.J., Ishii, I., Fukushima, N., Kingsbury, M.A., Ye, X., Kawamura, S., Brown, J.H., Chun, J. Mol. Cell. Biol. (2002)
- Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Zhang, G., Contos, J.J., Weiner, J.A., Fukushima, N., Chun, J. Gene (1999)
- Lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. Weiner, J.A., Hecht, J.H., Chun, J. J. Comp. Neurol. (1998)
- Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid. An, S., Dickens, M.A., Bleu, T., Hallmark, O.G., Goetzl, E.J. Biochem. Biophys. Res. Commun. (1997)
- Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes. Zheng, Y., Voice, J.K., Kong, Y., Goetzl, E.J. FASEB J. (2000)
- The mouse lp(A3)/Edg7 lysophosphatidic acid receptor gene: genomic structure, chromosomal localization, and expression pattern. Contos, J.J., Chun, J. Gene (2001)
- Neurochemical changes in LPA1 receptor deficient mice--a putative model of schizophrenia. Roberts, C., Winter, P., Shilliam, C.S., Hughes, Z.A., Langmead, C., Maycox, P.R., Dawson, L.A. Neurochem. Res. (2005)
- Lysophosphatidic acid (LPA) induces plasma exudation and histamine release in mice via LPA receptors. Hashimoto, T., Ohata, H., Honda, K. J. Pharmacol. Sci. (2006)
- Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1. Avendaño-Vázquez, S.E., García-Caballero, A., García-Sáinz, J.A. Biochem. J. (2005)
- Lysophosphatidic acid stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. Dubin, A.E., Bahnson, T., Weiner, J.A., Fukushima, N., Chun, J. J. Neurosci. (1999)
- Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. Sautin, Y.Y., Jorgensen, M., Petersen, B.E., Saulnier-Blache, J.S., Crawford, J.M., Svetlov, S.I. J. Hematother. Stem Cell Res. (2002)
- In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Yang, A.H., Ishii, I., Chun, J. Biochim. Biophys. Acta (2002)
- Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. Okusa, M.D., Ye, H., Huang, L., Sigismund, L., Macdonald, T., Lynch, K.R. Am. J. Physiol. Renal Physiol. (2003)
- Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process. Ramos, M.P., Rueda, B.R., Leavis, P.C., Gonzalez, R.R. Endocrinology (2005)
- The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts. Chuprun, J.K., Raymond, J.R., Blackshear, P.J. J. Biol. Chem. (1997)
- ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. Kumagai, N., Morii, N., Fujisawa, K., Nemoto, Y., Narumiya, S. J. Biol. Chem. (1993)
- Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1). Thompson, H.A., Burson, J.M., Lang, J.A., Gross, K.W., Sigmund, C.D. Endocrinology (1995)