The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

NDUFB11  -  NADH dehydrogenase (ubiquinone) 1 beta...

Homo sapiens

Synonyms: CI-ESSS, Complex I-ESSS, ESSS, NADH-ubiquinone oxidoreductase ESSS subunit, NP17.3, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of NDUFB11


High impact information on NDUFB11

  • Subunit ESSS has a cleaved mitochondrial import sequence and one potential transmembrane helix [2].
  • 3. In contrast, high anti-EA antibody-positive sera from nasopharyngeal carcinoma patients were relatively less reactive with these synthetic peptides (23% positive with p17.1; 19% with p17.2; and 13% with p17.3) [3].
  • There is no detectable complex I assembly and activity in the absence of the ESSS subunit as revealed by blue native polyacrylamide gel electrophoresis (BN/PAGE) analysis and polarography [4].
  • Field stimulation with platinum and carbon, but not with silver, electrodes (30 V, 30 HZ, 2-5 ms pulse width) as well as electrically stimulated salt (0.9% NaCl) solution (ESSS) or Krebs solution caused 100% relaxation of phenylephrine-contracted rat aortic strips, which was TTX and LNA resistant and endothelium independent [5].
  • ESSS also relaxed other vascular preparations (rabbit aorta and renal artery, dog coronary artery, pig ductus arteriosus, and rat portal vein) [5].

Biological context of NDUFB11

  • ESSS and NaOCl caused contraction failure of spontaneously beating right atria of rats and did not affect uterine contractions, vascular cAMP, cGMP, or the pH of the tissue bath [5].

Associations of NDUFB11 with chemical compounds

  • Field stimulation, ESSS, and NaOCl did not relax aortic preparations contracted by 32 mmol/L potassium and their vasorelaxant effects on phenylephrine-contracted rat aortic strips and rings were completely reversed by tetraethylammonium and partially by glibenclamide and iberiotoxin [5].

Analytical, diagnostic and therapeutic context of NDUFB11


  1. X-linked NDUFA1 gene mutations associated with mitochondrial encephalomyopathy. Fernandez-Moreira, D., Ugalde, C., Smeets, R., Rodenburg, R.J., Lopez-Laso, E., Ruiz-Falco, M.L., Briones, P., Martin, M.A., Smeitink, J.A., Arenas, J. Ann. Neurol. (2007) [Pubmed]
  2. Definition of the nuclear encoded protein composition of bovine heart mitochondrial complex I. Identification of two new subunits. Carroll, J., Shannon, R.J., Fearnley, I.M., Walker, J.E., Hirst, J. J. Biol. Chem. (2002) [Pubmed]
  3. Identification of T- and B-cell epitopes associated with a restricted component of the Epstein-Barr virus-induced early antigen complex. Pothen, S., Cao, T., Smith, R., Levine, P.H., Levine, A., Pearson, G.R. Int. J. Cancer (1993) [Pubmed]
  4. The role of the ESSS protein in the assembly of a functional and stable mammalian mitochondrial complex I (NADH-ubiquinone oxidoreductase). Potluri, P., Yadava, N., Scheffler, I.E. Eur. J. Biochem. (2004) [Pubmed]
  5. Field stimulation-induced tetrodotoxin-resistant vasorelaxation is mediated by sodium hypochlorite. Varma, D.R., Xia, Z., Ozgoli, M., Chemtob, S., Mulay, S. Can. J. Physiol. Pharmacol. (2006) [Pubmed]
WikiGenes - Universities