High impact information on Cycl

• However, after entering S phase, macrophages no longer require CSF-1 and can complete cell division without expressing CYL genes [1].
• The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment [1].
• The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues [2].
• Examination of electrophoretically resolved randomly generated PCR amplicons from mature murine oocytes revealed the presence of a short sequence with partial homology to a cyclin-like human uracil DNA glycosylase (UDG2), a member of an important group of base-excision enzymes that remove misincorporated or cytosine-derived uracil from nascent DNA [2].
• This suggested that additional cyclin-like activators, such as Munc-18, must be coexpressed with Cdk5 in some migrating neurons [3].

Biological context of Cycl

• The species specificity is probably dependent on the presence or absence of cyclin-like and/or mos-like molecules in fully grown oocytes [4].
• Although Nck5a has cyclin-like activity, it shows minimal amino acid sequence identity to members of cyclin family proteins [5].

Anatomical context of Cycl

• We suggest that uracil-excision repair in oocytes is likely to be mediated by Udg2v2, or alternatively that Udg2v2 is involved in a process related to oocyte-specific maturation by virtue of its cyclin-like domains [2].

Other interactions of Cycl

• Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo [6].

References