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Gene Review:

EPDR1 - ependymin related 1

Homo sapiens

Synonyms: EPDR, MERP-1, MERP1, Mammalian ependymin-related protein 1, UCC1, ...

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High impact information on EPDR1

Additionally, MERP1 expression in a hematopoietic stem cell enriched population was down-regulated with proliferation and differentiation [1].
Conceptual translation of the MERP1 open reading frame reveals significant homology to two families of glycoprotein calcium-dependant cell adhesion molecules: ependymins and protocadherins [1].
Expression of MERP1 was found in a variety of normal human tissues, and is 4- and 10-fold higher in adult bone marrow and umbilical cord blood CD34+ cells, respectively, compared to CD34- cells [1].
In addition, three human MERP pseudogenes were identified on chromosomes 8, 16, and X [2].
Remarkably, the UCC1 protein shows significant sequence similarity to the highly divergent piscine glycoproteins termed ependymins which are synthesized by leptomeningeal fibroblasts and secreted into the cerebrospinal fluid [3].

Analytical, diagnostic and therapeutic context of EPDR1

CONCLUSION: Overall interrater agreement for the NCC MERP index for categorizing medication errors was substantial [4].
This project maps the NCC MERP taxonomy of medication error to MedWatch medical errors involving infusion pumps [5].

References

MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells. Gregorio-King, C.C., McLeod, J.L., Collier, F.M., Collier, G.R., Bolton, K.A., Van Der Meer, G.J., Apostolopoulos, J., Kirkland, M.A. Gene (2002) [Pubmed]
Identification and characterization of a novel family of mammalian ependymin-related proteins (MERPs) in hematopoietic, nonhematopoietic, and malignant tissues. Apostolopoulos, J., Sparrow, R.L., McLeod, J.L., Collier, F.M., Darcy, P.K., Slater, H.R., Ngu, C., Gregorio-King, C.C., Kirkland, M.A. DNA Cell Biol. (2001) [Pubmed]
The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells. Nimmrich, I., Erdmann, S., Melchers, U., Chtarbova, S., Finke, U., Hentsch, S., Hoffmann, I., Oertel, M., Hoffmann, W., Müller, O. Cancer Lett. (2001) [Pubmed]
Interrater agreement with a standard scheme for classifying medication errors. Forrey, R.A., Pedersen, C.A., Schneider, P.J. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists (2007) [Pubmed]
Evaluating a medical error taxonomy. Brixey, J., Johnson, T.R., Zhang, J. Proceedings / AMIA ... Annual Symposium. AMIA Symposium. (2002) [Pubmed]

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