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Gene Review

fos  -  FBJ murine osteosarcoma viral oncogene...

Xenopus (Silurana) tropicalis

Synonyms: c-fos, xfos
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High impact information on fos

  • These findings show that Pl-3 kinase can stimulate diverse Ras-dependent cellular processes, including oocyte maturation and fos transcription [1].
  • Expression of p110 in NIH 3T3 cells induced transcription from the fos promoter [1].
  • The protein products of the jun and fos oncogenes require a functional protein-protein interaction domain, called the "leucine zipper domain", to exert their transcriptional regulatory activity [2].
  • In a Xenopus kidney cell line, the fos gene can be transcriptionally activated by serum growth factors and 12-O-tetradecanoylphorbol-13-acetate, and the fos mRNA can be superinduced by cycloheximide [3].
  • Nucleotide sequence analysis of the complementary DNA revealed a coding domain for a 370-amino acid protein which shares extensive sequence homology with the avian and mammalian fos protein [3].

Biological context of fos

  • Transient expression of fos can be seen during the late neurula and again at the tadpole stage [3].
  • The differential expression of fos during Xenopus development and its ability to regulate transcription in association with jun suggest a role during embryogenesis [3].

Anatomical context of fos

  • Interestingly, fos has been shown to be expressed preferentially in pachytene spermatocytes in the mouse [4].

Associations of fos with chemical compounds

  • Aldosterone action: induction of p21(ras) and fra-2 and transcription-independent decrease in myc, jun, and fos [5].


  1. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Hu, Q., Klippel, A., Muslin, A.J., Fantl, W.J., Williams, L.T. Science (1995) [Pubmed]
  2. An efficient screening assay for the rapid and precise determination of affinities between leucine zipper domains. Pernelle, C., Clerc, F.F., Dureuil, C., Bracco, L., Tocque, B. Biochemistry (1993) [Pubmed]
  3. Developmental expression of the Xenopus laevis fos protooncogene. Kindy, M.S., Verma, I.M. Cell Growth Differ. (1990) [Pubmed]
  4. Regulation of c-fos messenger ribonucleic acid by fibroblast growth factor in cultured Sertoli cells. Smith, E.P., Hall, S.H., Monaco, L., French, F.S., Wilson, E.M., Conti, M. Ann. N. Y. Acad. Sci. (1989) [Pubmed]
  5. Aldosterone action: induction of p21(ras) and fra-2 and transcription-independent decrease in myc, jun, and fos. Spindler, B., Verrey, F. Am. J. Physiol. (1999) [Pubmed]
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