High impact information on DUSP23

• In transfected cells, VHZ was located in the cytosol and in other cells also in the nucleoli [1].
• VHZ is broadly expressed in tissues and cells, including resting blood lymphocytes, Jurkat T cells, HL-60, and RAMOS [1].
• The minimal essential core of a cysteine-based protein-tyrosine phosphatase revealed by a novel 16-kDa VH1-like phosphatase, VHZ [1].
• Human VHZ is remarkably well conserved through evolution as it has species orthologs in frogs, fish, fly, and Archaea. The gene for VHZ, which we designate as DUSP25, is located on human chromosome 1q23.1 and consists of only two coding exons [1].
• Furthermore, DUSP23 could dephosphorylate p44ERK1 but not p38 and p54SAPKbeta in vitro [2].

Biological context of DUSP23

• Transient transfection experiment suggested that DUSP23 was localized in the cytoplasm of HEK293 cells [2].
• All the results indicated that DUSP23 was a novel protein phosphatase with dual substrate specificity [2].
• In this study, a novel human dual-specificity protein phosphatases gene named dual-specificity phosphatase 23 (DUSP23) was isolated by large-scale sequencing analysis of a human fetal brain cDNA library [2].

Anatomical context of DUSP23

• Reverse transcription-PCR (RT-PCR) revealed that the DUSP23 was expressed in most fetal tissues and two adult tissues: testis and colon [2].

Associations of DUSP23 with chemical compounds

• DUSP23 showed distinctive phosphatase activity toward p-nitrophenyl phosphate (pNPP), as well as oligopeptides containing phospho-tyrosine and phospho-threonine residues [2].

Analytical, diagnostic and therapeutic context of DUSP23

• Molecular cloning and characterization of a novel dual-specificity phosphatase 23 gene from human fetal brain [2].

References