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Gene Review

PPP1R7  -  protein phosphatase 1, regulatory subunit 7

Homo sapiens

Synonyms: Protein phosphatase 1 regulatory subunit 22, Protein phosphatase 1 regulatory subunit 7, SDS22, sds22
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High impact information on PPP1R7

  • However, we did find evidence of downregulated gene expression in CFLAR, CASP10 and PPP1R7 in CC cell lines [1].
  • Northern analysis revealed a major transcript of 1.39 kb in all 8 investigated human tissues. sds22 was detected by western analysis in both the cytoplasm and the nucleus of rat liver cells as a polypeptide of 44 kDa [2].
  • sds22 is a regulatory polypeptide of protein phosphatase-1 that is required for the completion of mitosis in both fission and budding yeast [2].
  • The human homolog of sds22 consists of 360 residues, has a calculated molecular mass of 41.6 kDa and shows a tandem array of 11 leucine-rich repeat structures of 22 residues [2].
  • Possible missense mutations of the PPP1R5, PPP1R7 and PPP1R8 genes were detected in one (2%), two (4%) and one (2%) cell line, respectively [3].

Biological context of PPP1R7


Anatomical context of PPP1R7


Analytical, diagnostic and therapeutic context of PPP1R7


  1. Genetic analysis identifies putative tumor suppressor sites at 2q35-q36.1 and 2q36.3-q37.1 involved in cervical cancer progression. Narayan, G., Pulido, H.A., Koul, S., Lu, X.Y., Harris, C.P., Yeh, Y.A., Vargas, H., Posso, H., Terry, M.B., Gissmann, L., Schneider, A., Mansukhani, M., Rao, P.H., Murty, V.V. Oncogene (2003) [Pubmed]
  2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. Renouf, S., Beullens, M., Wera, S., Van Eynde, A., Sikela, J., Stalmans, W., Bollen, M. FEBS Lett. (1995) [Pubmed]
  3. Genetic alterations and expression of the protein phosphatase 1 genes in human cancers. Takakura, S., Kohno, T., Manda, R., Okamoto, A., Tanaka, T., Yokota, J. Int. J. Oncol. (2001) [Pubmed]
  4. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. Ceulemans, H., Van Eynde, A., Pérez-Callejón, E., Beullens, M., Stalmans, W., Bollen, M. Eur. J. Biochem. (1999) [Pubmed]
  5. A sds22 homolog that is associated with the testis-specific serine/threonine protein phosphatase 1gamma2 in rat testis. Chun, Y.S., Park, J.W., Kim, G.T., Shima, H., Nagao, M., Kim, M.S., Chung, M.H. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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