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Gene Review

RBM23  -  RNA binding motif protein 23

Homo sapiens

Synonyms: CAPERbeta, FLJ10482, PP239, RNA-binding motif protein 23, RNA-binding region-containing protein 4, ...
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Disease relevance of RBM23


High impact information on RBM23


Biological context of RBM23

  • The general splicing factor SF2/ASF binds in a sequence-specific manner to a purine-rich exonic splicing enhancer (ESE) in the last exon of bovine growth hormone (bGH) pre-mRNA [4].
  • P32 protein, also known as the gC1q receptor for complement component C1q, is a binding protein for nuclear pre-mRNA splicing factor SF2/ASF and numerous other nuclear and cell surface proteins, yet is targeted to the mitochondrial matrix compartment where these proteins are not present [8].

Anatomical context of RBM23


Associations of RBM23 with chemical compounds

  • Interestingly, this hyaluronic acid-binding protein cDNA sequence has complete homology with the cDNA sequence of a protein P-32, co-purified with the human pre-mRNA splicing factor SF2 (Krainer, A.R., Mayeda, A., Kozak, D., and Binns, G. (1991) Cell 66, 383-394) [7].

Other interactions of RBM23


  1. Novel exploitation of a nuclear function by influenza virus: the cellular SF2/ASF splicing factor controls the amount of the essential viral M2 ion channel protein in infected cells. Shih, S.R., Krug, R.M. EMBO J. (1996) [Pubmed]
  2. Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2. Bennett, E.M., Lever, A.M., Allen, J.F. J. Virol. (2004) [Pubmed]
  3. Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Krainer, A.R., Mayeda, A., Kozak, D., Binns, G. Cell (1991) [Pubmed]
  4. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Sun, Q., Mayeda, A., Hampson, R.K., Krainer, A.R., Rottman, F.M. Genes Dev. (1993) [Pubmed]
  5. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Krainer, A.R., Conway, G.C., Kozak, D. Genes Dev. (1990) [Pubmed]
  6. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Ghigna, C., Giordano, S., Shen, H., Benvenuto, F., Castiglioni, F., Comoglio, P.M., Green, M.R., Riva, S., Biamonti, G. Mol. Cell (2005) [Pubmed]
  7. Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2. Deb, T.B., Datta, K. J. Biol. Chem. (1996) [Pubmed]
  8. Localization of P32 protein (gC1q-R) in mitochondria and at specific extramitochondrial locations in normal tissues. Soltys, B.J., Kang, D., Gupta, R.S. Histochem. Cell Biol. (2000) [Pubmed]
  9. cdc2 kinase-mediated phosphorylation of splicing factor SF2/ASF. Okamoto, Y., Onogi, H., Honda, R., Yasuda, H., Wakabayashi, T., Nimura, Y., Hagiwara, M. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  10. Convergence of RNA cis elements and cellular polyadenylation factors in the regulation of human cytomegalovirus UL37 exon 1 unspliced RNA production. Su, Y., Adair, R., Davis, C.N., DiFronzo, N.L., Colberg-Poley, A.M. J. Virol. (2003) [Pubmed]
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