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Gene Review

PPP2R3A  -  protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: PP2A subunit B isoform PR72/PR130, PP2A subunit B isoform R3 isoform, PP2A subunit B isoforms B''-PR72/PR130, PP2A subunit B isoforms B72/B130, PPP2R3, ...
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High impact information on PPP2R3A

  • Moreover, PR72 is required during early embryonic development to regulate cell morphogenetic movements during body axis formation [1].
  • We find that PR130 modulates Wnt signal transduction by restricting the ability of Naked cuticle to function as a Wnt inhibitor [2].
  • We have further evaluated the effects of Ca(2+) on subunit composition, subcellular targeting, catalytic activity, and function during the cell cycle of a PR72-containing PP2A trimer (PP2A(T72)) by site-directed mutagenesis of either or both motifs [3].
  • From brain we isolated cDNA clones spanning an open reading frame encoding a 130-kDa protein (termed PR130) [4].
  • Amino acid sequence data of the 72-kDa regulatory subunit (termed PR72) were used to isolate cDNAs from human heart and fetal brain libraries and libraries derived from WI-38 and MCF-7 cells [4].

Biological context of PPP2R3A


Physical interactions of PPP2R3A

  • The G90D alteration inhibited the interaction of Abeta with the B56gamma subunit but had no effect on binding to the PR72 subunit [7].

Analytical, diagnostic and therapeutic context of PPP2R3A

  • Our data provide evidence that the inhibitory effect of Naked cuticle on Wnt signaling depends on the presence of PR72, both in mammalian cell culture and in Xenopus embryos [1].
  • Sequence alignment of these A subunit binding domains (ASBD) identified conserved residues in B/B55 and PR72 family members [8].


  1. PR72, a novel regulator of Wnt signaling required for Naked cuticle function. Creyghton, M.P., Roël, G., Eichhorn, P.J., Hijmans, E.M., Maurer, I., Destrée, O., Bernards, R. Genes Dev. (2005) [Pubmed]
  2. PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle. Creyghton, M.P., Roël, G., Eichhorn, P.J., Vredeveld, L.C., Destrée, O., Bernards, R. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Identification and functional analysis of two Ca2+-binding EF-hand motifs in the B"/PR72 subunit of protein phosphatase 2A. Janssens, V., Jordens, J., Stevens, I., Van Hoof, C., Martens, E., De Smedt, H., Engelborghs, Y., Waelkens, E., Goris, J. J. Biol. Chem. (2003) [Pubmed]
  4. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. Hendrix, P., Mayer-Jackel, R.E., Cron, P., Goris, J., Hofsteenge, J., Merlevede, W., Hemmings, B.A. J. Biol. Chem. (1993) [Pubmed]
  5. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. Stevens, I., Janssens, V., Martens, E., Dilworth, S., Goris, J., Van Hoof, C. Eur. J. Biochem. (2003) [Pubmed]
  6. Fission yeast homologues of the B' subunit of protein phosphatase 2A: multiple roles in mitotic cell division and functional interaction with calcineurin. Tanabe, O., Hirata, D., Usui, H., Nishito, Y., Miyakawa, T., Igarashi, K., Takeda, M. Genes Cells (2001) [Pubmed]
  7. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. Esplin, E.D., Ramos, P., Martinez, B., Tomlinson, G.E., Mumby, M.C., Evans, G.A. Genes Chromosomes Cancer (2006) [Pubmed]
  8. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. Li, X., Virshup, D.M. Eur. J. Biochem. (2002) [Pubmed]
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