Disease relevance of LYAR

• Fibroblast cells overexpressing the LYAR cDNA from a retrovirus vector, though not phenotypically transformed in vitro, had increased ability to form tumors in nu/nu mice [1].
• Clonogenic assays were used to measure radiation response in MES-SA, A549 human lung carcinoma, E89, a CHO cell line variant deficient in glucose-6-phosphate dehydrogenase activity, and murine lymphoma cell lines LYAR and LYAS [2].

High impact information on LYAR

• The LYAR mRNA was not detected in brain, thymus, bone marrow, liver, heart, and muscle [1].
• During radiation-induced T-cell leukemogenesis, high levels of LYAR were expressed in preleukemic thymocytes and in acute T leukemia cells [1].
• However, the LYAR gene was expressed at very high levels in immature spermatocytes in testis [1].

Anatomical context of LYAR

• The LYAR mRNA is present at high levels in early embryos and preferentially in fetal liver and fetal thymus [1].

Analytical, diagnostic and therapeutic context of LYAR

• Antibodies raised against a LYAR fusion protein reacted with a protein of 45 kD on Western blots and by immunoprecipitation [1].

References