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Gene Review

LYAR  -  Ly1 antibody reactive

Homo sapiens

Synonyms: Cell growth-regulating nucleolar protein, PNAS-5, ZC2HC2, ZLYAR
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Disease relevance of LYAR


High impact information on LYAR

  • The LYAR mRNA was not detected in brain, thymus, bone marrow, liver, heart, and muscle [1].
  • During radiation-induced T-cell leukemogenesis, high levels of LYAR were expressed in preleukemic thymocytes and in acute T leukemia cells [1].
  • However, the LYAR gene was expressed at very high levels in immature spermatocytes in testis [1].

Anatomical context of LYAR

  • The LYAR mRNA is present at high levels in early embryos and preferentially in fetal liver and fetal thymus [1].

Analytical, diagnostic and therapeutic context of LYAR


  1. LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. Su, L., Hershberger, R.J., Weissman, I.L. Genes Dev. (1993) [Pubmed]
  2. Redox cycling by motexafin gadolinium enhances cellular response to ionizing radiation by forming reactive oxygen species. Magda, D., Lepp, C., Gerasimchuk, N., Lee, I., Sessler, J.L., Lin, A., Biaglow, J.E., Miller, R.A. Int. J. Radiat. Oncol. Biol. Phys. (2001) [Pubmed]
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