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Gene Review

PRKCD  -  protein kinase C, delta

Homo sapiens

Synonyms: ALPS3, CVID9, MAY1, PKCD, Protein kinase C delta type, ...
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Disease relevance of PRKCD

  • Correlation between translocation and down-regulation of conventional protein kinase C alpha (cPKC alpha) and new PKC delta (nPKC delta) induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) at different time courses (5 min, 30 min, 1 h, 3 h, 6 h, 10 h, 17 h, and 24 h) was studied in C6 glioma cells [1].

High impact information on PRKCD

  • However, the extent of down-regulation of nPKC delta was greater than that of cPKC alpha at 3-, 6-, and 10-h treatment [1].
  • We found that resveratrol inhibits PKD autophosphorylation in a concentration-dependent manner, but has only negligible effects against the autophosphorylation reactions of representative members of each PKC isozyme subfamily (cPKC-alpha, -beta(1), and -gamma, nPKC-delta and -epsilon, and aPKC-zeta) [2].
  • A decrease in cPKC alpha and-beta and an increase in nPKC delta were associated with the cDDP-resistant phenotype [3].
  • In this condition, the translocation of cPKC alpha, nPKC delta and nPKC epsilon induced by TPA still occurred, however, that of cPKC alpha was reduced more than in the normal condition [4].
  • On the other hand, when the cells were treated with 1 microM ionomycin, the translocation of cPKC alpha itself was observed while nPKC delta was not affected [5].

Biological context of PRKCD


Anatomical context of PRKCD


  1. Differential correlation between translocation and down-regulation of conventional and new protein kinase C isozymes in C6 glioma cells. Chen, C.C., Cheng, C.S., Chang, J., Huang, H.C. J. Neurochem. (1995) [Pubmed]
  2. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Stewart, J.R., Christman, K.L., O'Brian, C.A. Biochem. Pharmacol. (2000) [Pubmed]
  3. Characterization of the protein kinase C signal transduction pathway in cisplatin-sensitive and -resistant human small cell lung carcinoma cells. Basu, A., Weixel, K., Saijo, N. Cell Growth Differ. (1996) [Pubmed]
  4. Differential expression of protein kinase C isoforms in glial and neuronal cells. Translocation and down-regulation of PKC isoforms in C6 glioma and NG 108-15 hybrid cells: effects of extracellular Ca(2+)-depletion. Chen, C.C., Chang, J., Lin, W.W. Neurochem. Int. (1995) [Pubmed]
  5. Effects of Ca2+ on the activation of conventional and new PKC isozymes and on TPA and endothelin-1 induced translocations of these isozymes in intact cells. Chen, C.C. FEBS Lett. (1994) [Pubmed]
  6. Selective activation of protein kinase C delta in human neutrophils following ischemia reperfusion of skeletal muscle. Huda, R., Vergara, L.A., Solanki, D.R., Sherwood, E.R., Mathru, M. Shock (2004) [Pubmed]
  7. The myristoylated alanine-rich C-kinase substrate (MARCKS) is sequentially phosphorylated by conventional, novel and atypical isotypes of protein kinase C. Herget, T., Oehrlein, S.A., Pappin, D.J., Rozengurt, E., Parker, P.J. Eur. J. Biochem. (1995) [Pubmed]
  8. Protein kinase C alpha, delta, epsilon and zeta in C6 glioma cells. TPA induces translocation and down-regulation of conventional and new PKC isoforms but not atypical PKC zeta. Chen, C.C. FEBS Lett. (1993) [Pubmed]
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