Disease relevance of Cpxm2

• Expression of CPX-2 using the baculovirus system produced several forms of protein, from 80 to 105 kDa, but no detectable activity toward a variety of carboxypeptidase substrates [1].

High impact information on Cpxm2

• Areas that are enriched in CPX-2 include the hippocampus, cerebral cortex, median eminence, and choroid plexus [1].
• A shorter 50-kDa form of CPX-2, which contains the carboxypeptidase domain but not the discoidin domain, was also inactive when expressed in the baculovirus system [1].
• Taken together, these data suggest a widespread function for CPX-2, possibly as a binding protein rather than an active carboxypeptidase [1].
• CPX-2 is missing several of the predicted active-site residues that are conserved in most other members of the metallocarboxypeptidase gene family and which are thought to be required for enzyme activity [1].
• Linkage analysis using backcross mouse progeny indicated the mouse Cpx2 gene and its pseudogene to be located on mouse chromosomes 12 and 7, respectively [2].

Analytical, diagnostic and therapeutic context of Cpxm2

• Northern blot analysis showed CPX-2 mRNA in mouse brain, liver, kidney, and lung [1].

References