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Gene Review

AKIP1  -  A kinase (PRKA) interacting protein 1

Homo sapiens

Synonyms: A-kinase-interacting protein 1, BCA3, Breast cancer-associated gene 3 protein, C11orf17, PKA-interacting protein, ...
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Disease relevance of C11orf17

  • The DNA sequence for one of these breast cancer associated genes was used to construct the larger 1319 bp BCA3 cDNA sequence using ESTs without assigned names or functions [1].

High impact information on C11orf17

  • AAPK-dependent phosphorylation is required for the interaction of AKIP1 with messenger RNA that encodes dehydrin, a protein implicated in cell protection under stress conditions [2].
  • Here we show that AAPK-interacting protein 1 (AKIP1), with sequence homology to heterogeneous nuclear RNA-binding protein A/B, is a substrate of AAPK [2].
  • AAPK and AKIP1 are present in the guard-cell nucleus, and in vivo treatment of such cells with abscisic acid enhances the partitioning of AKIP1 into subnuclear foci which are reminiscent of nuclear speckles [2].
  • Upon stimulation with forskolin, HeLa cells expressing AKIP1 accumulated higher levels of the endogenous C subunit in the nucleus [3].
  • In silico study of breast cancer associated gene 3 using LION Target Engine and other tools [4].

Biological context of C11orf17


Anatomical context of C11orf17

  • High-level BCA3 mRNA expression was found in breast and prostate tumor cell lines whereas normal breast and prostate tissues have low-level expression [1].

Co-localisations of C11orf17

  • In fact, we observed that AKIP1 colocalized with p65 within the cells and appeared to retain p65 in nucleus [5].

Analytical, diagnostic and therapeutic context of C11orf17


  1. Characterization of a novel human breast cancer associated gene (BCA3) encoding an alternatively spliced proline-rich protein. Kitching, R., Li, H., Wong, M.J., Kanaganayakam, S., Kahn, H., Seth, A. Biochim. Biophys. Acta (2003) [Pubmed]
  2. Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase. Li, J., Kinoshita, T., Pandey, S., Ng, C.K., Gygi, S.P., Shimazaki, K., Assmann, S.M. Nature (2002) [Pubmed]
  3. A-kinase-interacting protein localizes protein kinase A in the nucleus. Sastri, M., Barraclough, D.M., Carmichael, P.T., Taylor, S.S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. In silico study of breast cancer associated gene 3 using LION Target Engine and other tools. León, D.A., Cànaves, J.M. BioTechniques (2003) [Pubmed]
  5. AKIP1 enhances NF-kappaB-dependent gene expression by promoting the nuclear retention and phosphorylation of p65. Gao, N., Asamitsu, K., Hibi, Y., Ueno, T., Okamoto, T. J. Biol. Chem. (2008) [Pubmed]
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