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Gene Review

Lat2  -  linker for activation of T cells family,...

Mus musculus

Synonyms: AW125574, LAB, Lab, Linker for activation of B-cells, Linker for activation of T-cells family member 2, ...
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Disease relevance of Lat2

  • Although NTAL is also expressed in plasma cells, its absence did not affect the hypergammaglobulinemia E and G1 that developed in mice with a mutation in tyrosine 136 of LAT [1].
  • The second data is serum samples from young male C57BL/6 mice subjected to instillation of pancreatic elastase producing emphysema type symptoms [C. Kuhn, S.Y. Yu, M. Chraplyvy, H.E. Linder, R.M. Senior, Lab. Invest. 34 (1976) 372-380; C. Kuhn, R.M. Senior, Lung 155 (1978) 185-197] [2].

High impact information on Lat2

  • Mice with the Lat2 gene conditionally deleted from T cells also developed the autoimmune syndrome like Lat2(-/-) mice [3].
  • Linker for activation of B cells (LAB, also called NTAL; a product of wbscr5 gene) is a newly identified transmembrane adaptor protein that is expressed in B cells, NK cells, and mast cells [4].
  • To clarify the role of NTAL in mast cell degranulation, we compared FcepsilonRI-mediated signaling events in BMMCs from NTAL-deficient and wild-type mice [5].
  • NTAL-deficient BMMCs also exhibited an enhanced activity of phosphatidylinositol 3-OH kinase and Src homology 2 domain-containing protein tyrosine phosphatase-2 [5].
  • Early activation events include tyrosine phosphorylation of two transmembrane adaptor proteins, linker for activation of T cells (LAT) and non-T cell activation linker (NTAL; also called LAB; a product of Wbscr5 gene) [5].

Biological context of Lat2


Anatomical context of Lat2

  • Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function [1].
  • NTAL (non-T-cell activation linker, also called LAB) and LAT (linker for activation of T cells) are evolutionarily related transmembrane adaptor proteins that are phosphorylated upon immunoreceptor engagement [1].
  • Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL [5].

Associations of Lat2 with chemical compounds

  • Upon B-cell antigen receptor cross-linking, Ntal(-/-) B cells exhibited slightly increased Ca(2+) mobilization and proliferation [1].

Other interactions of Lat2


Analytical, diagnostic and therapeutic context of Lat2


  1. Single and combined deletions of the NTAL/LAB and LAT adaptors minimally affect B-cell development and function. Wang, Y., Horvath, O., Hamm-Baarke, A., Richelme, M., Grégoire, C., Guinamard, R., Horejsi, V., Angelisova, P., Spicka, J., Schraven, B., Malissen, B., Malissen, M. Mol. Cell. Biol. (2005) [Pubmed]
  2. A study of spectral integration and normalization in NMR-based metabonomic analyses. Webb-Robertson, B.J., Lowry, D.F., Jarman, K.H., Harbo, S.J., Meng, Q.R., Fuciarelli, A.F., Pounds, J.G., Lee, K.M. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  3. Negative Regulation of T Cell Activation and Autoimmunity by the Transmembrane Adaptor Protein LAB. Zhu, M., Koonpaew, S., Liu, Y., Shen, S., Denning, T., Dzhagalov, I., Rhee, I., Zhang, W. Immunity (2006) [Pubmed]
  4. Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. Zhu, M., Liu, Y., Koonpaew, S., Granillo, O., Zhang, W. J. Exp. Med. (2004) [Pubmed]
  5. Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. Volná, P., Lebduska, P., Dráberová, L., Símová, S., Heneberg, P., Boubelík, M., Bugajev, V., Malissen, B., Wilson, B.S., Horejsí, V., Malissen, M., Dráber, P. J. Exp. Med. (2004) [Pubmed]
  6. Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells. Tessarz, A.S., Weiler, S., Zanzinger, K., Angelisová, P., Horejsí, V., Cerwenka, A. J. Immunol. (2007) [Pubmed]
  7. Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry. Nahm, D.H., Tkaczyk, C., Fukuishi, N., Colucci-Guyon, E., Gilfillan, A.M., Metcalfe, D.D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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