Disease relevance of FMN2

• Among various human tumors, FMN2 mRNA was expressed in parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma [1].
• Prospective identification of patients with meiosis I arrest is necessary to determine whether FMN2 mutations are a cause of unexplained infertility [2].

High impact information on FMN2

• Human FMN2 (1722 aa) showed 74.7% total-amino-acid identity with mouse Fmn2, and 31.9% total-amino-acid identity with human FMN1 [1].
• Characterization of FMN2 gene at human chromosome 1q43 [1].
• Here, we characterized human FMN2 gene by using bioinformatics [1].
• Complete coding sequence of human FMN2 cDNA was determined by assembling AL359918, AL513342, AL590490, AL646016 genome sequences, AF218941 partial cDNA, and AF218942 partial cDNA [1].
• FMN2 mRNA was expressed in fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells [1].

Biological context of FMN2

• RESULT(S): FMN2 includes 411,960 base pairs (bp) of DNA with 6,204 bp in 18 exons [2].
• There was no difference in FMN2 FMP allele frequencies between the controls and subjects [2].
• INTERVENTION(S): BLASTP (www.ncbi.nlm.nih.gov) was used to map the genomic DNA and complementary DNA sequence of FMN2 [2].

Other interactions of FMN2

• Exon-intron structure was conserved between FMN2 and FMN1 genes [1].
• The polymerase chain reaction was used to amplify FMN2 gene exons for analysis by denaturing gradient gel electrophoresis [2].

References