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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HTGS  -  Hypertriglyceridemia, familial

Homo sapiens

 
 
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High impact information on HTGS

  • Nevertheless, approximately 10% of myeloma-expressed sequences matched only entries in the database of Expressed Sequence Tags (dbEST) or the high-throughput genomic sequence (htgs) database [1].
  • Database searches with YAC content sequences identified two overlapping high throughput genomic sequencing phase (HTGS) entries which contained sequences homologous to the murine cng6 gene encoding the putative beta-subunit of the cone photoreceptor cGMP-gated channel [2].
  • ARHGAP12 is located in chromosome 10pter-cen and consists of 20 exons according to the Blastn result against high throughput genomic sequences (htgs) [3].
  • EST and HTGS databases were searched for orthologs of ELOVL4 [4].
  • An HERV-H env SU sequence (HERV-H19) was used to screen the high-throughput (htgs) and nonredundant (nr) databases for other HERV-H SU open reading frames (ORFs) and thus possible functional proteins [5].
 

Biological context of HTGS

  • Utilizing these BAC sequences in addition to mouse VNO receptor sequences, we screened the High Throughput Genome Sequence (HTGS) database to find additional human putative VNO receptor genes [6].
  • Analysis of the high-throughput genomic sequence (HTGS) database revealed that hPEPT1 and hPEPT1-RF are splice variants encoded by the same gene located in chromosome 13, consisting of 24 exons. hPEPT1 is encoded by 23 exons and hPEPT1-RF by 6 exons [7].
  • According to the genomic sequence from the HTGS database, the ZNF268 gene is assigned to human chromosome 5 [8].
  • With the aid of the htgs and dbEST databases, a novel cytochrome P450 cDNA was found by homology searches, and the corresponding gene was identified on chromosome 19 [9].
 

Other interactions of HTGS

  • The SULT1B1 gene sequence is part of a sequence entry in the unfinished High-Throughput Genomic Sequences (HTGS) division of GenBank [10].

References

  1. A molecular compendium of genes expressed in multiple myeloma. Claudio, J.O., Masih-Khan, E., Tang, H., Gonçalves, J., Voralia, M., Li, Z.H., Nadeem, V., Cukerman, E., Francisco-Pabalan, O., Liew, C.C., Woodgett, J.R., Stewart, A.K. Blood (2002) [Pubmed]
  2. Mutations in the CNGB3 gene encoding the beta-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21. Kohl, S., Baumann, B., Broghammer, M., Jägle, H., Sieving, P., Kellner, U., Spegal, R., Anastasi, M., Zrenner, E., Sharpe, L.T., Wissinger, B. Hum. Mol. Genet. (2000) [Pubmed]
  3. Cloning and characterization of ARHGAP12, a novel human rhoGAP gene. Zhang, Z., Wu, C., Wang, S., Huang, W., Zhou, Z., Ying, K., Xie, Y., Mao, Y. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  4. Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Zhang, X.M., Yang, Z., Karan, G., Hashimoto, T., Baehr, W., Yang, X.J., Zhang, K. Mol. Vis. (2003) [Pubmed]
  5. Full-length HERV-H elements with env SU open reading frames in the human genome. Jern, P., Lindeskog, M., Karlsson, D., Blomberg, J. AIDS Res. Hum. Retroviruses (2002) [Pubmed]
  6. Identification of non-functional human VNO receptor genes provides evidence for vestigiality of the human VNO. Kouros-Mehr, H., Pintchovski, S., Melnyk, J., Chen, Y.J., Friedman, C., Trask, B., Shizuya, H. Chem. Senses (2001) [Pubmed]
  7. Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant. Urtti, A., Johns, S.J., Sadée, W. AAPS PharmSci (2001) [Pubmed]
  8. Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo. Gou, D.M., Sun, Y., Gao, L., Chow, L.M., Huang, J., Feng, Y.D., Jiang, D.H., Li, W.X. Biochim. Biophys. Acta (2001) [Pubmed]
  9. Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1). Rylander, T., Neve, E.P., Ingelman-Sundberg, M., Oscarson, M. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  10. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. Meinl, W., Glatt, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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