Gene Review:
SLC15A1 - solute carrier family 15 (oligopeptide...
Homo sapiens
Synonyms:
HPECT1, HPEPT1, Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, PEPT1, ...
- Interactions of the dipeptide ester prodrugs of acyclovir with the intestinal oligopeptide transporter: competitive inhibition of glycylsarcosine transport in human intestinal cell line-Caco-2. Anand, B.S., Patel, J., Mitra, A.K. J. Pharmacol. Exp. Ther. (2003)
- Regulation of expression of the intestinal oligopeptide transporter (Pept-1) in health and disease. Adibi, S.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Regulation of human peptide transporter 1 (PEPT1) in gastric cancer cells by anticancer drugs. Inoue, M., Terada, T., Okuda, M., Inui, K. Cancer Lett. (2005)
- Solubilization and immunopurification of a somatostatin receptor from the human gastric tumoral cell line HGT-1. Reyl-Desmars, F., Le Roux, S., Linard, C., Benkouka, F., Lewin, M.J. J. Biol. Chem. (1989)
- Peptide transporter (TAP-1 and TAP-2)-independent endogenous processing of Epstein-Barr virus (EBV) latent membrane protein 2A: implications for cytotoxic T-lymphocyte control of EBV-associated malignancies. Khanna, R., Burrows, S.R., Moss, D.J., Silins, S.L. J. Virol. (1996)
- Model prodrugs for the intestinal oligopeptide transporter: model drug release in aqueous solution and in various biological media. Nielsen, C.U., Andersen, R., Brodin, B., Frokjaer, S., Steffansen, B. J. Control. Release. (2001)
- Mutation screening of two candidate genes from 13q32 in families affected with Bipolar disorder: human peptide transporter (SLC15A1) and human glypican5 (GPC5). Maheshwari, M., Christian, S.L., Liu, C., Badner, J.A., Detera-Wadleigh, S., Gershon, E.S., Gibbs, R.A. BMC Genomics (2002)
- The oligopeptide transporter (Pept-1) in human intestine: biology and function. Adibi, S.A. Gastroenterology (1997)
- Molecular and integrative physiology of intestinal peptide transport. Daniel, H. Annu. Rev. Physiol. (2004)
- Lactobacillus casei alters hPEPT1-mediated glycylsarcosine uptake in Caco-2 cells. Neudeck, B.L., Loeb, J.M., Faith, N.G. J. Nutr. (2004)
- The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology. Daniel, H., Kottra, G. Pflugers Arch. (2004)
- Interactions of amoxicillin and cefaclor with human renal organic anion and peptide transporters. Li, M., Anderson, G.D., Phillips, B.R., Kong, W., Shen, D.D., Wang, J. Drug Metab. Dispos. (2006)
- Genetic variants of the human dipeptide transporter PEPT1. Anderle, P., Nielsen, C.U., Pinsonneault, J., Krog, P.L., Brodin, B., Sadée, W. J. Pharmacol. Exp. Ther. (2006)
- In-depth evaluation of Gly-Sar transport parameters as a function of culture time in the Caco-2 cell model. Bravo, S.A., Nielsen, C.U., Amstrup, J., Frokjaer, S., Brodin, B. Eur. J. Pharm. Sci. (2004)
- Identification of the histidyl residue obligatory for the catalytic activity of the human H+/peptide cotransporters PEPT1 and PEPT2. Fei, Y.J., Liu, W., Prasad, P.D., Kekuda, R., Oblak, T.G., Ganapathy, V., Leibach, F.H. Biochemistry (1997)
- Transport of the phosphonodipeptide alafosfalin by the H+/peptide cotransporters PEPT1 and PEPT2 in intestinal and renal epithelial cells. Neumann, J., Bruch, M., Gebauer, S., Brandsch, M. Eur. J. Biochem. (2004)
- Differential recognition of beta -lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2. Ganapathy, M.E., Brandsch, M., Prasad, P.D., Ganapathy, V., Leibach, F.H. J. Biol. Chem. (1995)
- hPEPT1 is responsible for uptake and transport of Gly-Sar in the human bronchial airway epithelial cell-line Calu-3. Søndergaard, H.B., Brodin, B., Nielsen, C.U. Pflugers. Arch. (2008)
- Valacyclovir: a substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2. Ganapathy, M.E., Huang, W., Wang, H., Ganapathy, V., Leibach, F.H. Biochem. Biophys. Res. Commun. (1998)
- Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line. Nielsen, C.U., Supuran, C.T., Scozzafava, A., Frokjaer, S., Steffansen, B., Brodin, B. Pharm. Res. (2002)
- The renal type H(+)/peptide symporter PEPT2: structure-affinity relationships. Biegel, A., Knütter, I., Hartrodt, B., Gebauer, S., Theis, S., Luckner, P., Kottra, G., Rastetter, M., Zebisch, K., Thondorf, I., Daniel, H., Neubert, K., Brandsch, M. Amino Acids (2006)
- H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1. Knütter, I., Rubio-Aliaga, I., Boll, M., Hause, G., Daniel, H., Neubert, K., Brandsch, M. Am. J. Physiol. Gastrointest. Liver Physiol. (2002)
- Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells. Wenzel, U., Kuntz, S., Daniel, H. J. Pharmacol. Exp. Ther. (2001)
- In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Ekins, S., Johnston, J.S., Bahadduri, P., D'Souza, V.M., Ray, A., Chang, C., Swaan, P.W. Pharm. Res. (2005)
- Expression and functional characteristics of tubular transporters: P-glycoprotein, PEPT1, and PEPT2 in renal mass reduction and diabetes. Tramonti, G., Xie, P., Wallner, E.I., Danesh, F.R., Kanwar, Y.S. Am. J. Physiol. Renal Physiol. (2006)
- Loss of HLA molecules in B lymphomas is associated with an aggressive clinical course. Amiot, L., Onno, M., Lamy, T., Dauriac, C., Le Prise, P.Y., Fauchet, R., Drenou, B. Br. J. Haematol. (1998)
- Peptide transporter genes (TAP) polymorphisms and genetic susceptibility to rheumatoid arthritis. Vandevyver, C., Geusens, P., Cassiman, J.J., Raus, J. Br. J. Rheumatol. (1995)
- Genomic structure of proton-coupled oligopeptide transporter hPEPT1 and pH-sensing regulatory splice variant. Urtti, A., Johns, S.J., Sadée, W. AAPS PharmSci (2001)
- Comparison of human and monkey peptide transporters: PEPT1 and PEPT2. Zhang, E.Y., Emerick, R.M., Pak, Y.A., Wrighton, S.A., Hillgren, K.M. Mol. Pharm. (2004)
- An oligopeptide transporter is expressed at high levels in the pancreatic carcinoma cell lines AsPc-1 and Capan-2. Gonzalez, D.E., Covitz, K.M., Sadée, W., Mrsny, R.J. Cancer Res. (1998)
- Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter. Brandsch, M., Brandsch, C., Prasad, P.D., Ganapathy, V., Hopfer, U., Leibach, F.H. FASEB J. (1995)