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Gene Review

SULT1B1  -  sulfotransferase family, cytosolic, 1B,...

Homo sapiens

Synonyms: ST1B1, ST1B2, SULT1B2, Sulfotransferase 1B1, Sulfotransferase 1B2, ...
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Disease relevance of SULT1B1

  • Expression of ST1B1 and ST1B2 in COS-1 cells resulted in the appearance of 33.0 and 32.5 kDa proteins, respectively, whose mobilities were identical with proteins detected in rat and human livers in Western blots using antibodies raised against ST1B1 and ST1B2 produced in Escherichia coli [1].

High impact information on SULT1B1


Biological context of SULT1B1

  • SULT1B1 is located on chromosome 4q13.1, nearly 100 kb downstream of SULT1E1 on the same strand [3].
  • However, the order and orientation of the SULT1B1 exons are not correct in this entry [3].
  • Upon transfection of COS-7 cells with an expression vector (pcDNA3) harboring the cDNA encoding this new enzyme, a 34 kDa protein exhibiting immunologic cross-reactivity to antiserum against the rat liver SULT1B1 sulfotransferase was expressed [4].
  • Studies of 3-OH-BaP sulfonation by expressed human SULT1A1*1, SULT1A1*2, SULT1B1, and SULT1E1 showed that triclosan inhibited the activities of each of these purified enzymes with IC50 concentrations between 2.09 and 7.5 microM [5].

Anatomical context of SULT1B1

  • The male dog expresses more of SULT1B1 enzyme in the lower part of the small intestine while the female dog displays an opposite pattern of expression [6].
  • However, a correlation between SULT1A1 activity and protein level was observed in human placental cytosols, where SULT1B1 is not expressed [7].

Associations of SULT1B1 with chemical compounds


Other interactions of SULT1B1


Analytical, diagnostic and therapeutic context of SULT1B1


  1. Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases. Fujita, K., Nagata, K., Ozawa, S., Sasano, H., Yamazoe, Y. J. Biochem. (1997) [Pubmed]
  2. Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver. Wang, J., Falany, J.L., Falany, C.N. Mol. Pharmacol. (1998) [Pubmed]
  3. Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene. Meinl, W., Glatt, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  4. Molecular cloning, expression, and characterization of a novel mouse liver SULT1B1 sulfotransferase. Saeki, Y., Sakakibara, Y., Araki, Y., Yanagisawa, K., Suiko, M., Nakajima, H., Liu, M.C. J. Biochem. (1998) [Pubmed]
  5. Triclosan as a substrate and inhibitor of 3'-phosphoadenosine 5'-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions. Wang, L.Q., Falany, C.N., James, M.O. Drug Metab. Dispos. (2004) [Pubmed]
  6. Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog. Tsoi, C., Falany, C.N., Morgenstern, R., Swedmark, S. Arch. Biochem. Biophys. (2001) [Pubmed]
  7. Phenol sulfotransferase 1A1 activity in human liver: kinetic properties, interindividual variation and re-evaluation of the suitability of 4-nitrophenol as a probe substrate. Tabrett, C.A., Coughtrie, M.W. Biochem. Pharmacol. (2003) [Pubmed]
  8. Catecholestrogen sulfation: possible role in carcinogenesis. Adjei, A.A., Weinshilboum, R.M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. Enzymatic characterization of human cytosolic sulfotransferases; identification of ST1B2 as a thyroid hormone sulfotransferase. Fujita, K., Nagata, K., Yamazaki, T., Watanabe, E., Shimada, M., Yamazoe, Y. Biol. Pharm. Bull. (1999) [Pubmed]
  10. Sulfation of apomorphine by human sulfotransferases: evidence of a major role for the polymorphic phenol sulfotransferase, SULT1A1. Thomas, N.L., Coughtrie, M.W. Xenobiotica (2003) [Pubmed]
  11. Sulphation of o-desmethylnaproxen and related compounds by human cytosolic sulfotransferases. Falany, C.N., Ström, P., Swedmark, S. British journal of clinical pharmacology. (2005) [Pubmed]
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