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Gene Review

Rbms1  -  RNA binding motif, single stranded...

Mus musculus

Synonyms: 2600014B10Rik, AI255215, MSSP-1, MSSP-2, MSSP-3, ...
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High impact information on Rbms1


Biological context of Rbms1

  • Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice [2].
  • Furthermore, a chromosome location of human MSSP gene was identified at 2q24 by FISH mapping [3].
  • Mouse genomic MSSP gene was comprised of at least 13 exons over the region spanning 60 kb [3].
  • These results indicate that Fas-mediated apoptosis induced by MSSP occurs independently of mitochondria [4].

Anatomical context of Rbms1


Other interactions of Rbms1

  • We further found that expression of the Fas gene was repressed, resulting in abrogation of the Fas-mediated induction of apoptosis both in Mssp-knockout mice and primary thymocytes [4].


  1. Positive regulation of Fas gene expression by MSSP and abrogation of Fas-mediated apoptosis induction in MSSP-deficient mice. Nomura, J., Matsumoto, K., Iguchi-Ariga, S.M., Ariga, H. Exp. Cell Res. (2005) [Pubmed]
  2. Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice. Fujimoto, M., Matsumoto, K., Iguchi-Ariga, S.M., Ariga, H. Genes Cells (2001) [Pubmed]
  3. Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Fujimoto, M., Matsumoto, K.I., Iguchi-Ariga, S.M., Ariga, H. Int. J. Oncol. (2000) [Pubmed]
  4. Mitochondria-independent induction of Fas-mediated apoptosis by MSSP. Nomura, J., Matsumoto, K., Iguchi-Ariga, S.M., Ariga, H. Oncol. Rep. (2005) [Pubmed]
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