High impact information on Rbms1

• The knockout mice for the Mssp gene developed by us revealed that these mice became partially embryonic lethal due to a low concentration of progesterone at E2 [1].
• The cDNAs encoding four of the family proteins, MSSP-1, MSSP-2, Scr2 and Scr3, were cloned [2].
• The progesterone concentration of Mssp-/- mice was decrease to 6.5% of that of wild-type mice at E2 [2].
• Since Mssp was expressed in uterine gland-transported glycogen, we evaluated the hormonal state of wild-type and Mssp-/- mice [2].
• When E2.5 embryos from the pregnant mice were cultured in vitro for 5 days, the inner cell mass and trophoblast giant cells in wild-type (Mssp+/+) E2.5 embryos developed normally [2].

Biological context of Rbms1

• Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice [2].
• Furthermore, a chromosome location of human MSSP gene was identified at 2q24 by FISH mapping [3].
• Mouse genomic MSSP gene was comprised of at least 13 exons over the region spanning 60 kb [3].
• These results indicate that Fas-mediated apoptosis induced by MSSP occurs independently of mitochondria [4].

Anatomical context of Rbms1

• RESULTS: To elucidate its role in vivo, we generated Mssp knockout mice by homologous recombination in embryonic stem cells [2].

Other interactions of Rbms1

• We further found that expression of the Fas gene was repressed, resulting in abrogation of the Fas-mediated induction of apoptosis both in Mssp-knockout mice and primary thymocytes [4].

References