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Gene Review

RBMS1  -  RNA binding motif, single stranded...

Homo sapiens

Synonyms: C2orf12, DKFZp564H0764, HCC-4, MSSP, MSSP-1, ...
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Disease relevance of RBMS1

  • In addition, by using blocking peptides derived from HCR2 sequence, we have identified a second distinct region in SCR2 important in EBV binding [1].
  • Measles virus has recently been shown to interact with SCR1 and SCR2 [2].
  • Isolation and anti-fungal activities of 2-hydroxymethyl-chroman-4-one Produced by Burkholderia sp. MSSP [3].
  • The median MSSP1 concentration in 48 Down's syndrome pregnancies was significantly elevated at 1.17 multiples of the control median (MOM), and significantly reduced (0.5 MOM) in a group of eight cases of unbalanced translocations [4].
  • Both MSSP-1 and 2 induced apoptosis in a dose-dependent manner as in the control experiments with c-myc or adenovirus E1A [5].

High impact information on RBMS1

  • Thus, our data indicate that both SCR1 and SCR2 make up the MV receptor determinant in CD46 [6].
  • SCR-3 had no additional effect on SCR-1, and therefore the effect of SCR-2 was specific [7].
  • In conclusion, beta-chain SCR-2 contributes to the interaction of C4BP with protein S [7].
  • In addition to demonstrating an important role for the same sequence in SCR 1 that is part of the mAb OKB7 and EBV binding site, we have identified a new region within SCR 2 that interacts with C3 [8].
  • The single N-linked glycosylation site was confirmed at a location between SCR1 and SCR2, and the multiple O-linked oligosaccharides were localized to the S/T region [9].

Biological context of RBMS1


Anatomical context of RBMS1

  • In fact, overexpression of MSSP-1 in cultured smooth muscle cells suppresses the promoter activity [13].
  • In addition, we determined that short consensus repeat 2 (SCR2), -3, and -4 of the CD46 ectodomain were essential for the formation of the virus-induced syncytia [14].
  • Both genes determine resistance to the inhibitory action of cycloheximide on the ribosome, SCR1 and SCR2 are present as single copies in Schwanniomyces occidentalis, where they map on chromosomes II and V, respectively [15].
  • Induction of apoptosis in HeLa cells by MSSP, c-myc binding proteins [5].

Associations of RBMS1 with chemical compounds

  • We found that classical pathway C3 convertase regulatory function resides within SCR-2 and SCR-3, while alternative pathway C3 convertase regulatory function resides within SCR-2, -3, and -4 [16].
  • The E84 residues is localized in the SCR1-2 hinge and the deleterious effect of its substitution by an alanine residue could affect the relative orientation and / or tilt of SCR1 on SCR2 [17].
  • In this double-blind controlled trial, we decided to examine the beneficial effects of a single large dose of methylprednisolone (MSSP), using objective criteria [18].
  • Some enzymatic characteristics including the molecular structure and the substrate specificity for a lysine residue at the P(1) position are quite different not only from other fish MBSPs but also from soluble serine protease obtained from white croaker muscle (MSSP) [19].

Physical interactions of RBMS1

  • In this study, we found that MSSP binds to the N-terminal region of a catalytic subunit of a human DNA polymerase alpha via its RNP domains both in vitro and in human cells [20].
  • Calculations with 9950 models of CR2 SCR 1-2 bound to C3d through SCR 2 showed that SCR 1 formed an open V-shaped structure with SCR 2 and was capable of interacting with the surface of C3d [21].

Other interactions of RBMS1

  • They encode proteins of 403 (Scr2) and 407 (Scr3) amino acids [22].
  • MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity [20].
  • MSSP possesses versatile functions, including stimulation of DNA replication, transcriptional regulation, apoptosis induction, and cell transformation coordinated by c-Myc [20].
  • Computer modelling of the CR2 SCR1-2 solution structure was based on the structural randomisation of the eight-residue linker peptide joining SCR 1 and SCR 2 to give 9950 trial models [21].
  • However, virus binding and infection was always most effectively blocked by MAbs directed against the SCR 2 and 3 domains of DAF, suggesting that binding occurs at a similar site(s) on the molecule for all strains [23].

Analytical, diagnostic and therapeutic context of RBMS1


  1. Analysis of Epstein-Barr virus-binding sites on complement receptor 2 (CR2/CD21) using human-mouse chimeras and peptides. At least two distinct sites are necessary for ligand-receptor interaction. Molina, H., Brenner, C., Jacobi, S., Gorka, J., Carel, J.C., Kinoshita, T., Holers, V.M. J. Biol. Chem. (1991) [Pubmed]
  2. Artificial mutations and natural variations in the CD46 molecules from human and monkey cells define regions important for measles virus binding. Hsu, E.C., Dörig, R.E., Sarangi, F., Marcil, A., Iorio, C., Richardson, C.D. J. Virol. (1997) [Pubmed]
  3. Isolation and anti-fungal activities of 2-hydroxymethyl-chroman-4-one Produced by Burkholderia sp. MSSP. Kang, J.G., Shin, S.Y., Kim, M.J., Bajpai, V., Maheshwari, D.K., Kang, S.C. J. Antibiot. (2004) [Pubmed]
  4. Variation in the levels of pregnancy-specific beta-1-glycoprotein in maternal serum from chromosomally abnormal pregnancies. Graham, G.W., Crossley, J.A., Aitken, D.A., Connor, J.M. Prenat. Diagn. (1992) [Pubmed]
  5. Induction of apoptosis in HeLa cells by MSSP, c-myc binding proteins. Iida, M., Taira, T., Ariga, H., Iguchi-Ariga, S.M. Biol. Pharm. Bull. (1997) [Pubmed]
  6. Measles virus and C3 binding sites are distinct on membrane cofactor protein (CD46). Manchester, M., Valsamakis, A., Kaufman, R., Liszewski, M.K., Alvarez, J., Atkinson, J.P., Lublin, D.M., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. Interaction between protein S and complement C4b-binding protein (C4BP). Affinity studies using chimeras containing c4bp beta-chain short consensus repeats. van de Poel, R.H., Meijers, J.C., Bouma, B.N. J. Biol. Chem. (1999) [Pubmed]
  8. Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules. Molina, H., Perkins, S.J., Guthridge, J., Gorka, J., Kinoshita, T., Holers, V.M. J. Immunol. (1995) [Pubmed]
  9. Mapping of epitopes, glycosylation sites, and complement regulatory domains in human decay accelerating factor. Coyne, K.E., Hall, S.E., Thompson, S., Arce, M.A., Kinoshita, T., Fujita, T., Anstee, D.J., Rosse, W., Lublin, D.M. J. Immunol. (1992) [Pubmed]
  10. Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele. Vik, D.P., Wong, W.W. J. Immunol. (1993) [Pubmed]
  11. Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene. Negishi, Y., Nishita, Y., Saëgusa, Y., Kakizaki, I., Galli, I., Kihara, F., Tamai, K., Miyajima, N., Iguchi-Ariga, S.M., Ariga, H. Oncogene (1994) [Pubmed]
  12. Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity. Takai, T., Nishita, Y., Iguchi-Ariga, S.M., Ariga, H. Nucleic Acids Res. (1994) [Pubmed]
  13. c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription of alpha-smooth muscle actin gene in chicken visceral smooth muscle cells. Kimura, K., Saga, H., Hayashi, K., Obata, H., Chimori, Y., Ariga, H., Sobue, K. Nucleic Acids Res. (1998) [Pubmed]
  14. Human herpesvirus 6 variant A but not variant B induces fusion from without in a variety of human cells through a human herpesvirus 6 entry receptor, CD46. Mori, Y., Seya, T., Huang, H.L., Akkapaiboon, P., Dhepakson, P., Yamanishi, K. J. Virol. (2002) [Pubmed]
  15. Two different genes from Schwanniomyces occidentalis determine ribosomal resistance to cycloheximide. Del Pozo, L., Abarca, D., Hoenicka, J., Lmenez, A. Eur. J. Biochem. (1993) [Pubmed]
  16. Localization of classical and alternative pathway regulatory activity within the decay-accelerating factor. Brodbeck, W.G., Liu, D., Sperry, J., Mold, C., Medof, M.E. J. Immunol. (1996) [Pubmed]
  17. Evidence for distinct complement regulatory and measles virus binding sites on CD46 SCR2. Christiansen, D., Deléage, G., Gerlier, D. Eur. J. Immunol. (2000) [Pubmed]
  18. High-dose methylprednisolone as initial therapy in patients with acute bronchospasm. Schneider, S.M., Pipher, A., Britton, H.L., Borok, Z., Harcup, C.H. The Journal of asthma : official journal of the Association for the Care of Asthma. (1988) [Pubmed]
  19. A novel type of myofibril-bound serine protease from white croaker (Argyrosomus argentatus). Ohkubo, M., Osatomi, K., Hara, K., Ishihara, T., Aranishi, F. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2005) [Pubmed]
  20. MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity. Niki, T., Galli, I., Ariga, H., Iguchi-Ariga, S.M. FEBS Lett. (2000) [Pubmed]
  21. Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study. Gilbert, H.E., Eaton, J.T., Hannan, J.P., Holers, V.M., Perkins, S.J. J. Mol. Biol. (2005) [Pubmed]
  22. SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins. Kanaoka, Y., Nojima, H. Nucleic Acids Res. (1994) [Pubmed]
  23. Cardiovirulent coxsackieviruses and the decay-accelerating factor (CD55) receptor. Martino, T.A., Petric, M., Brown, M., Aitken, K., Gauntt, C.J., Richardson, C.D., Chow, L.H., Liu, P.P. Virology (1998) [Pubmed]
  24. Mapping of the sites responsible for factor I-cofactor activity for cleavage of C3b and C4b on human C4b-binding protein (C4bp) by deletion mutagenesis. Fukui, A., Yuasa-Nakagawa, T., Murakami, Y., Funami, K., Kishi, N., Matsuda, T., Fujita, T., Seya, T., Nagasawa, S. J. Biochem. (2002) [Pubmed]
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