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Gene Review

KIF15  -  kinesin family member 15

Homo sapiens

Synonyms: HKLP2, KLP2, KNSL7, Kinesin-like protein 2, Kinesin-like protein 7, ...
 
 
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High impact information on KIF15

  • In a previous study, we demonstrated that the forkhead associated (FHA) domain of pKi-67 interacts with the novel kinesin-like protein, Hklp2 (Sueishi, M., Takagi, M., and Yoneda, Y. (2000) J. Biol. Chem. 275, 28888-28892) [1].
  • These findings suggest that pKi-67 is involved in the progression of mitosis via its interaction with Hklp2 [2].
  • In addition, immunofluorescence using specific antibodies revealed an association between pKi-67 and Hklp2 at the periphery of mitotic chromosomes, largely in close proximity to the centromeres [2].
  • The interaction domain of Hklp2 was mapped to the portion that comprised residues 1017-1237 and that was phosphorylated in vitro by incubating with mitotic but not interphasic HeLa cell extracts [2].
  • Thus, repp86 may function in targeting Hklp2 to the microtubule minus ends, its activity being regulated by phosphorylation of serine/threonine residues [3].
 

Biological context of KIF15

 

Other interactions of KIF15

  • With regard to expression profiles, two of the novel gene products, NY-BR-62 and NY-BR-85, were characterized by a high level of testicular mRNA expression, and were overexpressed in 60% and 90% of breast cancers, respectively [4].

References

  1. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. Takagi, M., Sueishi, M., Saiwaki, T., Kametaka, A., Yoneda, Y. J. Biol. Chem. (2001) [Pubmed]
  2. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. Sueishi, M., Takagi, M., Yoneda, Y. J. Biol. Chem. (2000) [Pubmed]
  3. repp86: A human protein associated in the progression of mitosis. Heidebrecht, H.J., Adam-Klages, S., Szczepanowski, M., Pollmann, M., Buck, F., Endl, E., Kruse, M.L., Rudolph, P., Parwaresch, R. Mol. Cancer Res. (2003) [Pubmed]
  4. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Scanlan, M.J., Gout, I., Gordon, C.M., Williamson, B., Stockert, E., Gure, A.O., Jäger, D., Chen, Y.T., Mackay, A., O'Hare, M.J., Old, L.J. Cancer Immun. (2001) [Pubmed]
 
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