Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

SGOL1 - shugoshin-like 1 (S. pombe)

Homo sapiens

Synonyms: NY-BR-85, SGO, SGO1, Serologically defined breast cancer antigen NY-BR-85, Sgo1, ...

Kitajima, T.S. et al., Yang, Y. et al., Scanlan, M.J. et al., Feng, J. et al., Gandhi, R. et al., et al.

Watanabe, Kitajima, Scanlan, Gout, Gordon, Williamson, Stockert, Gure, Jäger, Chen, Mackay, O'Hare, Old, Suzuki, Akiyama, Tsuji, Ohashi, Saito, Eto,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SGOL1

Depletion of Bub1 or Shugoshin (Sgo1) in HeLa cells by RNA interference causes massive missegregation of sister chromatids that originates at centromeres [1].
Reduction of cohesin relieves the Wapl-depletion phenotype, and depletion of Wapl rescues premature sister separation observed in Sgo1-depleted or Esco2-depleted cells [2].
Here, we show that the persistence of human Scc1 at centromeres in mitosis is indeed dependent on human Sgo1 [3].
Remarkably, in these cells, Sgo1 relocates to chromosomes all along their length and provokes ectopic protection from dissociation of Scc1 on chromosome arms [3].
Cells depleted of CENP-F exit mitosis in the presence of defective kinetochore attachments resulting from treatment with nocodazole, or the depletion of kinetochore proteins CENP-E and hSgo1 [4].

Biological context of SGOL1

We demonstrate that human Sgo1 fails to localize at centromeres in Bub1-repressed cells, and centromeric cohesion is significantly loosened [3].
The human shugoshin homologue (hSgo1) is required to protect the centromeric localization of the mitotic cohesin, Scc1, until metaphase [5].
Bub1 and the MEI-S332/Shugoshin (Sgo1) family of proteins protect centromeric cohesin from mitotic kinases during prophase [6].
Here we demonstrate that hSgo mediates kinetochore-driven formation of kinetochore -microtubules (MTs) during bipolar spindle assembly [7].
Human Sgo1 is an excellent target for induction of apoptosis of transformed cells [8].

Anatomical context of SGOL1

Interestingly, WI-38 diploid fibroblasts were rather resistant to the treatment with Sgo1 peptide [8].
Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics [9].

Other interactions of SGOL1

With regard to expression profiles, two of the novel gene products, NY-BR-62 and NY-BR-85, were characterized by a high level of testicular mRNA expression, and were overexpressed in 60% and 90% of breast cancers, respectively [10].

Analytical, diagnostic and therapeutic context of SGOL1

Moreover, the reduction in HeLa cell viability after treatment with Sgo1 peptide resulted from induction of apoptosis [8].

References

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Tang, Z., Sun, Y., Harley, S.E., Zou, H., Yu, H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
Human Wapl Is a Cohesin-Binding Protein that Promotes Sister-Chromatid Resolution in Mitotic Prophase. Gandhi, R., Gillespie, P.J., Hirano, T. Curr. Biol. (2006) [Pubmed]
Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization. Kitajima, T.S., Hauf, S., Ohsugi, M., Yamamoto, T., Watanabe, Y. Curr. Biol. (2005) [Pubmed]
CENP-F is a novel microtubule-binding protein that is essential for kinetochore attachments and affects the duration of the mitotic checkpoint delay. Feng, J., Huang, H., Yen, T.J. Chromosoma (2006) [Pubmed]
Shugoshin protects cohesin complexes at centromeres. Watanabe, Y., Kitajima, T.S. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2005) [Pubmed]
PP2A Is Required for Centromeric Localization of Sgo1 and Proper Chromosome Segregation. Tang, Z., Shu, H., Qi, W., Mahmood, N.A., Mumby, M.C., Yu, H. Dev. Cell (2006) [Pubmed]
Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules. Suzuki, H., Akiyama, N., Tsuji, M., Ohashi, T., Saito, S., Eto, Y. Cell Cycle (2006) [Pubmed]
Human Sgo1 is an excellent target for induction of apoptosis of transformed cells. Yang, Y., Wang, X., Dai, W. Cell Cycle (2006) [Pubmed]
Differential subcellular localizations of two human Sgo1 isoforms: implications in regulation of sister chromatid cohesion and microtubule dynamics. Wang, X., Yang, Y., Dai, W. Cell Cycle (2006) [Pubmed]
Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Scanlan, M.J., Gout, I., Gordon, C.M., Williamson, B., Stockert, E., Gure, A.O., Jäger, D., Chen, Y.T., Mackay, A., O'Hare, M.J., Old, L.J. Cancer Immun. (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

SGOL1	Canis lupus familiaris
SGOL1	Gallus gallus
SGOL1	Macaca mulatta
Sgol1	Mus musculus
SGOL1	Pan troglodytes
Sgol1	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.