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Gene Review

AVEN  -  apoptosis, caspase activation inhibitor

Homo sapiens

Synonyms: Cell death regulator Aven, PDCD12
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Disease relevance of AVEN

  • 1) AVE and AVEN significantly increased with increasing body weight (BW) as has been reported previously, but no such correlation was found between AHR and BW [1].
  • The aim of this study was to determine the two distinct antiapoptotic signals-survivin and aven-in acute leukemias and compare them with clinical and hematological findings and response to therapy [2].
  • There was no important association between survivin or aven and performance status, lymphadenopathy or organomegaly [2].
  • Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia [3].
  • These findings demonstrate that Aven expression can predict prognosis in childhood ALL [3].

High impact information on AVEN

  • Thus, Aven represents a new class of cell death regulator [4].
  • RESULTS: Survivin was between 0.0 and 0.829 copy number/cell (median 0.0721, mean 0.5424301909 +/- 0.139799488589) and aven was between 0.0 and 0.853 copy number/cell (median 0.0124, mean 0.070335542 +/- 0.1524685709) [2].
  • In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome [3].
  • Aven expression was found to be higher in patients >or=10 years old or <1 year (P=0.003), and in patients with unfavorable cytogenetic abnormalities (P<0.001) [3].
  • Comparing survivin and aven between EPO and MPS treatment groups showed no significance (P = .3027, .2171, respectively) [5].

Biological context of AVEN


Other interactions of AVEN

  • 2) VO2 at rest was found to be positively correlated with AVE and AVEN but not with AHR [1].

Analytical, diagnostic and therapeutic context of AVEN

  • Real-time quantitative PCR was used and survivin and aven were detected at the messenger (m)RNA level [2].


  1. Ventilatory and heart rate responses to hypoxia in well-trained judo athletes. Ohyabu, Y., Yoshida, A., Hayashi, F., Nishibayashi, Y., Sakakibara, Y., Sato, N., Honda, Y. European journal of applied physiology and occupational physiology. (1984) [Pubmed]
  2. Survivin and aven: two distinct antiapoptotic signals in acute leukemias. Paydas, S., Tanriverdi, K., Yavuz, S., Disel, U., Sahin, B., Burgut, R. Ann. Oncol. (2003) [Pubmed]
  3. Aven overexpression: association with poor prognosis in childhood acute lymphoblastic leukemia. Choi, J., Hwang, Y.K., Sung, K.W., Kim, D.H., Yoo, K.H., Jung, H.L., Koo, H.H. Leuk. Res. (2006) [Pubmed]
  4. Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1. Chau, B.N., Cheng, E.H., Kerr, D.A., Hardwick, J.M. Mol. Cell (2000) [Pubmed]
  5. Expression of antiapoptotic survivin and aven genes in rat heart tissue after traumatic brain injury. Ozisik, K., Ozisik, P., Yildirim, E., Misirlioglu, M., Tuncer, S. Transplant. Proc. (2006) [Pubmed]
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