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Gene Review

Ly6i  -  lymphocyte antigen 6 complex, locus I

Mus musculus

Synonyms: AI789751, Ly-6I, Ly-6M, Ly6m, Lymphocyte antigen 6I, ...
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Disease relevance of Ly6i

  • Analysis of variants of the CH27 B cell lymphoma revealed that Ly-6A/E and Ly-6I recognized different molecules [1].

High impact information on Ly6i

  • Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins [2].
  • Ly-6M is broadly distributed in the bone marrow, with prominent expression on monocytes and myeloid precursors [2].
  • Ly-6M protein is detectable on 10% to 15% of peripheral blood leukocytes, including monocytes and a subpopulation of B220(+) cells [2].
  • Ly-6M messenger RNA (mRNA) is easily detectable in hematopoietic tissue (bone marrow, spleen, thymus, peritoneal macrophages) as well as kidney and lung [2].
  • The identification and characterization of Ly-6M adds a new member to a complex family of homologous, tightly linked genes that have proven extremely useful reagents for defining populations within the hematopoietic system [2].

Anatomical context of Ly6i


Regulatory relationships of Ly6i


Other interactions of Ly6i

  • CH27 cells with low levels of Ly-6A/E ligand activity also lost expression of CD22, and cells transfected with CD22 gained the ability to bind the Ly-6A/E chimera and, to a lesser extent, the Ly-6C and Ly-6I chimeric proteins [1].


  1. Ly-6 superfamily members Ly-6A/E, Ly-6C, and Ly-6I recognize two potential ligands expressed by B lymphocytes. Pflugh, D.L., Maher, S.E., Bothwell, A.L. J. Immunol. (2002) [Pubmed]
  2. Characterization of Ly-6M, a novel member of the Ly-6 family of hematopoietic proteins. Patterson, J.M., Johnson, M.H., Zimonjic, D.B., Graubert, T.A. Blood (2000) [Pubmed]
  3. Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern of expression. Pflugh, D.L., Maher, S.E., Bothwell, A.L. J. Immunol. (2000) [Pubmed]
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